公开(公告)号：US5747467A

公开(公告)日：1998-05-05

申请号：US767954

申请日：1996-12-19

申请人： Constantin Agouridas ,  Fran.cedilla.ois Bretin ,  Jean-Fran.cedilla.ois Chantot

发明人： Constantin Agouridas ,  Fran.cedilla.ois Bretin ,  Jean-Fran.cedilla.ois Chantot

IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  A61P31/12 ,  A61P31/16 ,  C07H17/00 ,  C07H17/08

CPC分类号： C07H17/08 ,  C07H17/00

摘要： A compound selected from the group consisting of a compound of the formula ##STR1## wherein X is selected from the group consisting of --(NH).sub.a --, --CH.sub.2 --, --SO.sub.2 -- and --O--, a is 0 or 1, Y is --(CH.sub.2).sub.m - (CH.dbd.CH).sub.n --(CH.sub.2).sub.o -, m+n+o.ltoreq.8, n=o or 1, Ar is aryl optionally substituted with at least one member of the group consisting of --OH, halogen, --NO.sub.2, --CN, ##STR2## and alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, -N-alkyl, -N-alkenyl and N-alkynyl of up to 12 carbon atoms, R.sub.a and R.sub.b individually are hydrogen or alkyl of up to 12 carbon atoms, R.sub.3 is selected from the group consisting of alkyl of 1 to 12 carbon atoms, aryl, heteroaryl, carbocyclic aryl, aryloxy, arylthio and heterocyclic aryl, heterocyclic aryloxy and heterocyclic arylthio of 5 to 6 ring members containing at least one heteroatom, Hal is halogen, Z is hydrogen or acyl of an organic carboxylic acid and their non-toxic, pharmaceutically acceptable addition salts having antibacterial properties.

摘要翻译： 选自下列化学式的化合物的化合物其中X选自 - （NH）a - ， - CH 2 - ， - SO 2 - 和-O-，a为0或1 ，Y是 - （CH 2）m - （CH = CH）n - （CH 2）o-，m + n + o = 8，n = 0或1，Ar是任选被至少一个 由-OH，卤素，-NO 2，-CN，和烷基，烯基，炔基，烷氧基，烯氧基，炔氧基，烷硫基，烯硫基，炔硫基，-N-烷基，-N-链烯基和N-炔基组成的组 至多12个碳原子，R a和R b分别为氢或至多12个碳原子的烷基，R 3选自1至12个碳原子的烷基，芳基，杂芳基，碳环芳基，芳氧基，芳硫基和杂环芳基 ，含有至少一个杂原子的5至6个环成员的杂环芳氧基和杂环芳硫基，Hal是卤素，Z是氢或有机羧酸的酰基及其无毒的药学上可接受的加成盐，其具有抗菌性 关系