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公开(公告)号：US08071757B2
公开(公告)日：2011-12-06
申请号：US12161717
申请日：2007-03-02
IPC分类号： A61K31/728 , C08B37/00
CPC分类号： A61K8/735 , A61K31/728 , A61K47/36 , A61K2800/52 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C08B37/0072 , C08L5/08
摘要： A hyaluronic acid derivative, and methods of producing and using said derivative, the derivative comprising n repeating units and having the general structural formula (I), wherein, in at least one repeating unit, one or more of R1, R2, R3, R4 comprises an etherbound aryl/alkyl sulfone having the general structural formula (II), wherein R comprises an alkyl- or aryl-group, and otherwise R1, R2, R3, R4 are hydroxyl groups, OH.
摘要翻译： 透明质酸衍生物，以及所述衍生物的制造和使用方法，所述衍生物包含n个重复单元并具有通式结构式（I），其中在至少一个重复单元中，R 1，R 2，R 3，R 4中的一个或多个 包括具有通式结构式（II）的醚键芳基/烷基砜，其中R包括烷基 - 或芳基，并且否则R 1，R 2，R 3，R 4是羟基，OH。
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公开(公告)号：US20140106411A1
公开(公告)日：2014-04-17
申请号：US14017085
申请日：2013-09-03
CPC分类号： C12P19/04 , A61K8/11 , A61K8/735 , A61K2800/412 , A61K2800/413 , A61Q7/00 , A61Q19/00 , C08B37/0072
摘要： The present invention relates to the modification of hyaluronic acid (HA) with aryl/alkyl succinic anhydrides (ASA) to produce aryl/alkyl succinic anhydride HA derivatives, to the derivatives as such, and to their applications and uses, particularly in the cosmetic and biomedical industries. The ASA-HA derivatives are expected to have interesting properties that can be used for advanced formulation (bind stronger to the skin compared to non-modified HA), possibly also in delivery systems for actives or drugs by encapsulation (nano/micro capsules) or formation of nano/micro spheres. Further, the low MW ASA-HA derivatives are expected to penetrate the skin more efficiently than non-modified HA of the same MW.
摘要翻译： 本发明涉及透明质酸（HA）与芳基/烷基琥珀酸酐（ASA）的修饰，以产生芳基/烷基琥珀酸酐HA衍生物，衍生物本身以及其应用和用途，特别是在化妆品和 生物医药行业。 ASA-HA衍生物预期具有有趣的性质，可用于高级配方（与未修饰的HA相比，与皮肤相比更强），也可能通过包封（纳米/微胶囊）或活性物质或药物的递送系统（纳米/微胶囊）或 形成纳米/微球。 此外，低MW ASA-HA衍生物预期比相同MW的非修饰HA更有效地渗透皮肤。
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公开(公告)号：US20120283213A1
公开(公告)日：2012-11-08
申请号：US13554190
申请日：2012-07-20
IPC分类号： C08B37/08 , A61P29/00 , A61K31/728 , B82Y5/00
CPC分类号： C12P19/04 , A61K8/11 , A61K8/735 , A61K2800/412 , A61K2800/413 , A61Q7/00 , A61Q19/00 , C08B37/0072
摘要： The present invention relates to the modification of hyaluronic acid (HA) with aryl/alkyl succinic anhydrides (ASA) to produce aryl/alkyl succinic anhydride HA derivatives, to the derivatives as such, and to their applications and uses, particularly in the cosmetic and biomedical industries. The ASA-HA derivatives are expected to have interesting properties that can be used for advanced formulation (bind stronger to the skin compared to non-modified HA), possibly also in delivery systems for actives or drugs by encapsulation (nano/micro capsules) or formation of nano/micro spheres. Further, the low MW ASA-HA derivatives are expected to penetrate the skin more efficiently than non-modified HA of the same MW.
摘要翻译： 本发明涉及透明质酸（HA）与芳基/烷基琥珀酸酐（ASA）的修饰，以产生芳基/烷基琥珀酸酐HA衍生物，衍生物本身以及其应用和用途，特别是在化妆品和 生物医药行业。 ASA-HA衍生物预期具有有趣的性质，可用于高级配方（与未修饰的HA相比，与皮肤相比更强），也可能通过包封（纳米/微胶囊）或活性物质或药物的递送系统（纳米/微胶囊）或 形成纳米/微球。 此外，低MW ASA-HA衍生物预期比相同MW的非修饰HA更有效地渗透皮肤。
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公开(公告)号：US07993678B2
公开(公告)日：2011-08-09
申请号：US11572954
申请日：2006-08-26
CPC分类号： C12P19/04 , A61K8/11 , A61K8/735 , A61K2800/412 , A61K2800/413 , A61Q7/00 , A61Q19/00 , C08B37/0072
摘要： The present invention relates to the modification of hyaluronic acid (HA) with aryl/alkyl succinic anhydrides (ASA) to produce aryl/alkyl succinic anhydride HA derivatives, to the derivatives as such, and to their applications and uses, particularly in the cosmetic and biomedical industries. The ASA-HA derivatives are expected to have interesting properties that can be used for advanced formulation (bind stronger to the skin compared to non-modified HA), possibly also in delivery systems for actives or drugs by encapsulation (nano/micro capsules) or formation of nano/micro spheres. Further, the low MW ASA-HA derivatives are expected to penetrate the skin more efficiently than non-modified HA of the same MW.
摘要翻译： 本发明涉及透明质酸（HA）与芳基/烷基琥珀酸酐（ASA）的修饰，以产生芳基/烷基琥珀酸酐HA衍生物，衍生物本身以及其应用和用途，特别是在化妆品和 生物医药行业。 ASA-HA衍生物预期具有有趣的性质，可用于高级配方（与未修饰的HA相比，与皮肤相比更强），也可能通过包封（纳米/微胶囊）或活性物质或药物的递送系统（纳米/微胶囊）或 形成纳米/微球。 此外，低MW ASA-HA衍生物预期比相同MW的非修饰HA更有效地渗透皮肤。
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公开(公告)号：US20110319357A1
公开(公告)日：2011-12-29
申请号：US13164012
申请日：2011-06-20
IPC分类号： A61K31/728 , A61P29/00 , A61P39/06 , C08B37/08
CPC分类号： C12P19/04 , A61K8/11 , A61K8/735 , A61K2800/412 , A61K2800/413 , A61Q7/00 , A61Q19/00 , C08B37/0072
摘要： The present invention relates to the modification of hyaluronic acid (HA) with aryl/alkyl succinic anhydrides (ASA) to produce aryl/alkyl succinic anhydride HA derivatives, to the derivatives as such, and to their applications and uses, particularly in the cosmetic and biomedical industries. The ASA-HA derivatives are expected to have interesting properties that can be used for advanced formulation (bind stronger to the skin compared to non-modified HA), possibly also in delivery systems for actives or drugs by encapsulation (nano/micro capsules) or formation of nano/micro spheres. Further, the low MW ASA-HA derivatives are expected to penetrate the skin more efficiently than non-modified HA of the same MW.
摘要翻译： 本发明涉及透明质酸（HA）与芳基/烷基琥珀酸酐（ASA）的修饰，以产生芳基/烷基琥珀酸酐HA衍生物，衍生物本身以及其应用和用途，特别是在化妆品和 生物医药行业。 ASA-HA衍生物预期具有有趣的性质，可用于高级配方（与未修饰的HA相比，与皮肤相比更强），也可能通过包封（纳米/微胶囊）或活性物质或药物的递送系统（纳米/微胶囊）或 形成纳米/微球。 此外，低MW ASA-HA衍生物预期比相同MW的非修饰HA更有效地渗透皮肤。
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6.发明申请ARYL/ALKYL VINYL SULFONE HYALURONIC ACID DERIVATIVES 失效ARYL / ALKYL VINYL SULFONE HYALURONIC ACID DERIVATIVES公开(公告)号：US20110257123A1
公开(公告)日：2011-10-20
申请号：US12161717
申请日：2007-03-02
IPC分类号： A61K31/728 , A61P17/14 , A61P17/02 , C08B37/08 , A61P19/02
CPC分类号： A61K8/735 , A61K31/728 , A61K47/36 , A61K2800/52 , A61Q7/00 , A61Q19/00 , A61Q19/08 , C08B37/0072 , C08L5/08
摘要： A hyaluronic acid derivative, and methods of producing and using said derivative, the derivative comprising n repeating units and having the general structural formula (I), wherein, in at least one repeating unit, one or more of R1, R2, R3, R4 comprises an etherbound aryl/alkyl sulfone having the general structural fomula (II), wherein R comprises an alkyl- or aryl-group, and otherwise R1, R2, R3, R4 are hydroxyl groups, OH.
摘要翻译： 透明质酸衍生物，以及所述衍生物的制造和使用方法，所述衍生物包含n个重复单元并具有通式结构式（I），其中在至少一个重复单元中，R 1，R 2，R 3，R 4中的一个或多个 包括具有通式结构式（II）的醚键芳基/烷基砜，其中R包括烷基或芳基，并且否则R 1，R 2，R 3，R 4为羟基。
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公开(公告)号：US20090252810A1
公开(公告)日：2009-10-08
申请号：US11572954
申请日：2006-09-26
CPC分类号： C12P19/04 , A61K8/11 , A61K8/735 , A61K2800/412 , A61K2800/413 , A61Q7/00 , A61Q19/00 , C08B37/0072
摘要： The present invention relates to the modification of hyaluronic acid (HA) with aryl/alkyl succinic anhydrides (ASA) to produce aryl/alkyl succinic anhydride HA derivatives, to the derivatives as such, and to their applications and uses, particularly in the cosmetic and biomedical industries. The ASA-HA derivatives are expected to have interesting properties that can be used for advanced formulation (bind stronger to the skin compared to non-modified HA), possibly also in delivery systems for actives or drugs by encapsulation (nano/micro capsules) or formation of nano/micro spheres. Further, the low MW ASA-HA derivatives are expected to penetrate the skin more efficiently than non-modified HA of the same MW.
摘要翻译： 本发明涉及透明质酸（HA）与芳基/烷基琥珀酸酐（ASA）的修饰，以产生芳基/烷基琥珀酸酐HA衍生物，衍生物本身以及其应用和用途，特别是在化妆品和 生物医药行业。 ASA-HA衍生物预期具有有趣的性质，可用于高级配方（与未修饰的HA相比，与皮肤相比更强），也可能通过包封（纳米/微胶囊）或活性物质或药物的递送系统（纳米/微胶囊）或 形成纳米/微球。 此外，低MW ASA-HA衍生物预期比相同MW的非修饰HA更有效地穿透皮肤。
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