公开(公告)号：US11547778B2

公开(公告)日：2023-01-10

申请号：US16800059

申请日：2020-02-25

申请人： CorneaGen Inc.

发明人： Edward J. Holland ,  Kevin Potts ,  Timothy G. Baldwin

IPC分类号： A61L27/36 ,  A61F2/14 ,  A61F9/007 ,  A61F9/013

摘要： A technique can consistently achieve thicknesses of ≤50 μm for corneal tissue for Descemet stripping automated endothelial keratoplasty (DSAEK). Grafts with thicknesses of ≤50 μm are also known as nanothin DSAEK (NT-DSAEK) grafts. Evidence shows that using thinner DSAEK grafts, particularly NT-DSAEK grafts, can significantly improve visual outcomes. According to an example embodiment, a method for producing a corneal graft includes drying a donor cornea to cause a pre-cut thickness of the donor cornea to decrease. The method includes, concurrently with drying the donor cornea, determining pre-cut thickness measurements for the donor cornea. The method includes, in response to the pre-cut thickness measurements indicating the pre-cut thickness of the donor cornea has decreased to a predetermined value, cutting the donor cornea to a post-cut thickness of ≤100 μm, or more particularly ≤50 μm, to produce a corneal graft.

公开(公告)号：US12016970B2

公开(公告)日：2024-06-25

申请号：US18070737

申请日：2022-11-29

申请人： CorneaGen Inc.

发明人： Edward J. Holland ,  Kevin Potts ,  Timothy G. Baldwin

IPC分类号： A61F2/14 ,  A61F9/007 ,  A61L27/36 ,  A61F9/013

CPC分类号： A61L27/3691 ,  A61F2/142 ,  A61L27/3604 ,  A61F9/007 ,  A61F9/0133 ,  A61L2430/16

摘要： A technique can consistently achieve thicknesses of ≤50 μm for corneal tissue for for Descemet stripping automated endothelial keratoplasty (DSAEK). Grafts with thicknesses of ≤50 μm are also known as nanothin DSAEK (NT-DSAEK) grafts. Evidence shows that using thinner DSAEK grafts, particularly NT-DSAEK grafts, can significantly improve visual outcomes. According to an example embodiment, a method for producing a corneal graft includes drying a donor cornea to cause a pre-cut thickness of the donor cornea to decrease. The method includes, concurrently with drying the donor cornea, determining pre-cut thickness measurements for the donor cornea. The method includes, in response to the precut thickness measurements indicating the pre-cut thickness of the donor cornea has decreased to a predetermined value, cutting the donor cornea to a post-cut thickness of ≤100 μm, or more particularly ≤50 μm, to produce a corneal graft.

公开(公告)号：US20230097900A1

公开(公告)日：2023-03-30

申请号：US18070737

申请日：2022-11-29

申请人： CorneaGen Inc.

发明人： Edward J. Holland ,  Kevin Potts ,  Timothy G. Baldwin

IPC分类号： A61L27/36 ,  A61F2/14

摘要： A technique can consistently achieve thicknesses of ≤ 50 µm for corneal tissue for for Descemet stripping automated endothelial keratoplasty (DSAEK). Grafts with thicknesses of ≤ 50 µm are also known as nanothin DSAEK (NT-DSAEK) grafts. Evidence shows that using thinner DSAEK grafts, particularly NT-DSAEK grafts, can significantly improve visual outcomes. According to an example embodiment, a method for producing a corneal graft includes drying a donor cornea to cause a pre-cut thickness of the donor cornea to decrease. The method includes, concurrently with drying the donor cornea, determining pre-cut thickness measurements for the donor cornea. The method includes, in response to the precut thickness measurements indicating the pre-cut thickness of the donor cornea has decreased to a predetermined value, cutting the donor cornea to a post-cut thickness of ≤ 100 µm, or more particularly ≤ 50 µm, to produce a corneal graft.