公开(公告)号：US20200038472A1

公开(公告)日：2020-02-06

申请号：US16569573

申请日：2019-09-12

申请人： Cornell Research Foundation, Inc. ,  Institut De Recherches Cliniques de Montreal

发明人： Hazel H. Szeto ,  Peter W. Schiller ,  Kesheng Zhao

IPC分类号： A61K38/07 ,  A61K38/03 ,  C07K5/103 ,  C07K5/107 ,  C07K5/11 ,  C07K5/117

摘要： The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2 a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.

公开(公告)号：US08957030B2

公开(公告)日：2015-02-17

申请号：US13778994

申请日：2013-02-27

申请人： Cornell Research Foundation, Inc. ,  Institut de Recherches Cliniques de Montreal

发明人： Hazel H. Szeto ,  Peter W. Schiller ,  Kesheng Zhao

IPC分类号： A61K38/07 ,  A61K38/03 ,  A61K38/00 ,  C07K5/00 ,  C07K5/10 ,  C07K5/11 ,  C07K5/103 ,  C07K5/107 ,  C07K5/117

CPC分类号： A61K38/07 ,  A61K38/03 ,  C07K5/1008 ,  C07K5/1016 ,  C07K5/1019 ,  C07K5/1024

摘要： The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2 a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.

摘要翻译： 本发明提供了减少或预防线粒体渗透性转换的方法。 该方法包括施用有效量的具有至少一个净正电荷的芳族阳离子肽; 至少四个氨基酸; 最多约20个氨基酸; 净正电荷（pm）的最小数量与氨基酸残基总数（r）之间的关系，其中3pm是小于或等于r + 1的最大数量; 以及芳族基团（a）的最小数量和净正电荷总数（pt）之间的关系，其中2 a是小于或等于pt + 1的最大数目，除了当a为1时，pt 也可能是1。

公开(公告)号：US20230293624A1

公开(公告)日：2023-09-21

申请号：US17668744

申请日：2022-02-10

申请人： Cornell Research Foundation, Inc. ,  Institut De Recherches Cliniques De Montreal

发明人： Hazel H. Szeto ,  Peter W. Schiller ,  Kesheng Zhao

IPC分类号： A61K38/07 ,  A61K38/03 ,  C07K5/103 ,  C07K5/107 ,  C07K5/11 ,  C07K5/117

CPC分类号： A61K38/07 ,  A61K38/03 ,  C07K5/1008 ,  C07K5/1016 ,  C07K5/1019 ,  C07K5/1024

摘要： The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2 a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.

公开(公告)号：US20150359838A1

公开(公告)日：2015-12-17

申请号：US14595946

申请日：2015-01-13

申请人： Cornell Research Foundation, Inc. ,  Institut de Recherches Cliniques de Montreal

发明人： Hazel H. Szeto ,  Peter W. Schiller ,  Kesheng Zhao

IPC分类号： A61K38/07

CPC分类号： A61K38/07 ,  A61K38/03 ,  C07K5/1008 ,  C07K5/1016 ,  C07K5/1019 ,  C07K5/1024

摘要： The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2 a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.

摘要翻译： 本发明提供了减少或预防线粒体渗透性转换的方法。 该方法包括施用有效量的具有至少一个净正电荷的芳族阳离子肽; 至少四个氨基酸; 最多约20个氨基酸; 净正电荷（pm）的最小数量与氨基酸残基总数（r）之间的关系，其中3pm是小于或等于r + 1的最大数量; 以及芳族基团（a）的最小数量和净正电荷总数（pt）之间的关系，其中2 a是小于或等于pt + 1的最大数目，除了当a为1时，pt 也可能是1。