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公开(公告)号：US20170226051A1
公开(公告)日：2017-08-10
申请号：US15519054
申请日：2015-10-14
发明人： Ram A. Vishwakarma , Sandip B. Bharate , Ajay Kumar , Baljinder Singh , Ashok Kumar , Shashi Bhushan , Abid Hamid , Prashant Joshi , Santosh K. Guru , Suresh Kumar , Aashiq Hussain , Asif K. Qazi , Sonali S. Bharate , Parduman Sharma , Ajit K. Saxena , Dilip M. Mondhe , Girish Mahajan , Zahoor Wani
IPC分类号： C07C233/41 , C07C231/12
CPC分类号： C07C233/41 , A61K31/165 , C07C231/12 , C07C2603/34
摘要： The present invention relates to the compounds of formula I wherein R is as herein described. The present invention particularly relates to synthesis and antiproliferative activity of 10-substituted colchicinoids. Compounds of the invention can be used for prevention or in the treatment of cancer disease.
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公开(公告)号：US09868695B2
公开(公告)日：2018-01-16
申请号：US15519054
申请日：2015-10-14
发明人： Ram A. Vishwakarma , Sandip B. Bharate , Ajay Kumar , Baljinder Singh , Ashok Kumar , Shashi Bhushan , Abid Hamid , Prashant Joshi , Santosh K. Guru , Suresh Kumar , Aashiq Hussain , Asif K. Qazi , Sonali S. Bharate , Parduman Sharma , Ajit K. Saxena , Dilip M. Mondhe , Girish Mahajan , Zahoor Wani
IPC分类号： C07C233/41 , C07C231/12 , A61K31/165
CPC分类号： C07C233/41 , A61K31/165 , C07C231/12 , C07C2603/34
摘要： The present invention relates to the compounds of formula I wherein R is as herein described. The present invention particularly relates to synthesis and antiproliferative activity of 10-substituted colchicinoids. Compounds of the invention can be used for prevention or in the treatment of cancer disease.
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