公开(公告)号：US20050236564A1

公开(公告)日：2005-10-27

申请号：US10832822

申请日：2004-04-26

申请人： Craig Keller ,  Curtis Lomax ,  Edward Wallerstein ,  Timothy Montagne ,  Michael Youngquist

发明人： Craig Keller ,  Curtis Lomax ,  Edward Wallerstein ,  Timothy Montagne ,  Michael Youngquist

IPC分类号： H01J49/04 ,  H01J49/16

CPC分类号： H01J49/164 ,  H01J49/0413 ,  H01J49/0418

摘要： Systems and methods for rastering a series of illumination pulses across the surface of a sample under investigation in a mass spectrometer system so as to create a two dimensional illumination pattern (raster pattern) on the sample. A probe interface that engages a probe is configured to translate the probe along a first direction, and a pulse deflection mechanism is configured to vary the pulse-probe intersect position along a second direction. A control system, implementing a rastering algorithm, provides control signals to the pulse deflection mechanism to adjust the pulse path and the probe translation mechanism to adjust the probe position so that each illumination pulse impinges on one of a plurality of addressable locations on the sample. The resulting raster pattern may cover the entire sample or one or more portions of the sample, depending on the spot size and the displacement distances for each pulse along the first and second directions. Ions desorbed from the sample by each pulse are detected, and a corresponding series of spectra are generated for each of the series of pulses. The spectrum resulting from each pulse may be combined with others to form a combined spectrum for the portion of the sample illuminated by the raster pattern.

摘要翻译： 用于在质谱仪系统中对正在研究的样品的表面上的一系列照明脉冲进行扫描以在样品上产生二维照明图案（光栅图案）的系统和方法。 接合探针的探针接口被配置为沿着第一方向平移探针，并且脉冲偏转机构被配置为沿着第二方向改变脉冲 - 探针相交位置。 控制系统实现了一种复原算法，向脉冲偏转机构提供控制信号，以调整脉冲路径和探头平移机构，以调整探头位置，使得每个照明脉冲射入样本上的多个可寻址位置之一。 取决于沿着第一和第二方向的每个脉冲的光斑尺寸和位移距离，所得到的光栅图案可以覆盖样品的整个样品或一个或多个部分。 检测每个脉冲从样品中脱离的离子，并为每个脉冲序列产生相应的一系列光谱。 每个脉冲产生的光谱可以与其他脉冲组合，以形成由光栅图案照射的样本部分的组合光谱。