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公开(公告)号:US20100055736A1
公开(公告)日:2010-03-04
申请号:US12516220
申请日:2007-11-28
申请人: Cristian Smerdou Picazo , Erkuden Casales Zoco , Juan Roberto Rodriguez Madoz , Nerea Razquin Erro , Yolanda Cuevas Labrador , Marta Ruiz Guillén , Jesüs Prieto Valtuena
发明人: Cristian Smerdou Picazo , Erkuden Casales Zoco , Juan Roberto Rodriguez Madoz , Nerea Razquin Erro , Yolanda Cuevas Labrador , Marta Ruiz Guillén , Jesüs Prieto Valtuena
CPC分类号: C12N15/86 , C12N2770/36143
摘要: The invention relates to a viral vector comprising a mutated replicon of the Semliki Forest virus (SFV) in the nucleotide sequence encoding subunit nsp2 of the SFV replicase. Said viral vector can be used to generate stable cell lines which can constitutively express heterologous products of interest.
摘要翻译: 本发明涉及包含编码SFV复制酶亚单位nsp2的核苷酸序列中的Semliki Forest病毒(SFV)的突变复制子的病毒载体。 所述病毒载体可用于产生可以组成型表达感兴趣的异源产物的稳定细胞系。