公开(公告)号：US20240254254A1

公开(公告)日：2024-08-01

申请号：US18593028

申请日：2024-03-01

申请人： Crosslink Therapeutics Inc.

发明人： Rodolfo J. CHAPARRO ,  Ronald D. SEIDEL, III

IPC分类号： C07K16/30 ,  A61K38/00 ,  C07K14/525 ,  C07K14/54 ,  C07K14/55 ,  C07K14/57 ,  C07K14/705 ,  C07K16/28

CPC分类号： C07K16/30 ,  C07K14/525 ,  C07K14/5255 ,  C07K14/5418 ,  C07K14/5428 ,  C07K14/5434 ,  C07K14/5443 ,  C07K14/55 ,  C07K14/57 ,  C07K14/70521 ,  C07K14/70532 ,  C07K14/70575 ,  C07K16/2803 ,  C07K16/2806 ,  C07K16/2809 ,  C07K16/2812 ,  C07K16/2815 ,  C07K16/2818 ,  C07K16/2866 ,  C07K16/2875 ,  C07K16/2896 ,  A61K38/00 ,  C07K2318/10 ,  C07K2319/30

摘要： The present disclosure provides polypeptide constructs that act as agonists of immune cell function when exposed to sufficient levels of ATP to cause their assembly into dimers or higher level complexes (e.g., trimers, tetramers, etc.). The complexes of the constructs are capable of stimulating immune cells (e.g., cytotoxic CD8+ T cell and/or NK cells) that function to promote anti-tumor immune responses. The constructs may be employed as anticancer agents/therapeutics for the treatment of solid tumors that have elevated levels of ATP.