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公开(公告)号:US20160367638A1
公开(公告)日:2016-12-22
申请号:US15104843
申请日:2014-12-17
申请人: Crystal BYERS , Shari Lynn CAPLAN , Gabriel Grant GAMBER , Seung HAHM , Kurt Alex HELDWEIN , Igor SPLAWSKI , Thomas ZABAWA , Frédéric ZECRI
发明人: Crystal BYERS , Shari Lynn CAPLAN , Gabriel GAMBERS , Seung HAHM , Kurt Alex HELDWEIN , Igor SPLAWSKI , Thomas ZABAWA , Frédéric ZECRI
CPC分类号: A61K38/2264 , A61K9/0019 , A61K9/1617 , A61K9/1641 , A61K9/5123 , A61K31/7105 , A61K47/543 , A61K48/00 , A61K48/0025 , A61K48/005 , A61K48/0075 , A61K48/0091
摘要: A formulation comprising a modified synthetic messenger RNA and a delivery agent. The modified synthetic messenger RNA encodes a leptin protein, is non-replicating and is translation-ready. The formulation can be delivered to a subject with congenital leptin deficiency, lipodystrophy or other condition where circulating leptin level is low.
摘要翻译: 包含修饰的合成信使RNA和递送试剂的制剂。 修饰的合成信使RNA编码瘦素蛋白,是非复制型并且是翻译准备的。 该制剂可以递送到具有先天性瘦素缺乏症,脂肪营养不良或循环瘦素水平低的其他病症的受试者。