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公开(公告)号:US09504747B2
公开(公告)日:2016-11-29
申请号:US14200359
申请日:2014-03-07
申请人: Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
发明人: Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
IPC分类号: A61K47/18 , C07C229/12 , A61K47/22 , A61K9/127 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/22 , C07C219/28 , C07C235/46 , C07C237/08 , C07D213/79 , C07D317/24 , C07D317/28 , C07D205/04 , C07D295/096 , C07D213/69 , C12N15/113
CPC分类号: A61K47/18 , A61K9/1271 , A61K9/1272 , A61K47/183 , A61K47/22 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/22 , C07C219/28 , C07C229/12 , C07C235/46 , C07C237/08 , C07D205/04 , C07D213/69 , C07D213/79 , C07D295/096 , C07D317/24 , C07D317/28 , C12N15/1137 , C12N2310/14 , C12N2320/32
摘要: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号:US20150299181A1
公开(公告)日:2015-10-22
申请号:US14688397
申请日:2015-04-16
申请人: Gregory Raymond BEBERNITZ , Emma CODY , Tajesh PATEL , Ming QIAN , Lewis WHITEHEAD , Thomas ZABAWA , Frederic ZECRI
发明人: Gregory Raymond BEBERNITZ , Emma CODY , Tajesh PATEL , Ming QIAN , Lewis WHITEHEAD , Thomas ZABAWA , Frederic ZECRI
IPC分类号: C07D417/12 , A61K31/41 , C07D405/14 , A61K31/428 , A61K31/343 , C07D407/12 , A61K31/357 , A61K31/443 , C07D405/04 , C07D307/85
CPC分类号: C07D405/04 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/41 , A61K31/428 , A61K31/443 , A61K31/4439 , A61K31/5377 , C07D307/85 , C07D405/12 , C07D405/14 , C07D407/12 , C07D417/12 , C07D417/14
摘要: The present invention provides a compound of formula I, in which R1, R2, X and R3 are defined in the Summary of the Invention, or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译: 本发明提供式I化合物或其药学上可接受的盐,其中R 1,R 2,X和R 3在发明概述中定义。 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号:US10125092B2
公开(公告)日:2018-11-13
申请号:US15505282
申请日:2015-09-04
申请人: Rohan Eric John Beckwith , Luis Brito , Brian Addison Dechristopher , Gabriel Grant Gamber , Andrew Geall , Thomas Zabawa
发明人: Rohan Eric John Beckwith , Luis Brito , Brian Addison Dechristopher , Gabriel Grant Gamber , Andrew Geall , Thomas Zabawa
IPC分类号: A61K9/127 , A61K48/00 , C12N15/85 , C07K14/535 , C07C219/06 , A61K47/18 , A61K47/22 , A61K9/51 , A61K31/7105 , A61K31/711 , A61K31/713 , C07C229/12 , C07D211/62 , C07C219/16 , C07D211/34 , C07D295/15 , C07C217/58 , C07D207/08
摘要: This invention provides for a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein RA, RB, R2 and R4 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号:US20140303232A1
公开(公告)日:2014-10-09
申请号:US14200359
申请日:2014-03-07
申请人: Jeremy Lee BARYZA , Rohan Eric John BECKWITH , Keith BOWMAN , Crystal BYERS , Tanzina FAZAL , Gabriel Grant GAMBER , Cameron Chuck-munn LEE , Ritesh Bhanudasji TICHKULE , Chandra VARGEESE , Shuangxi WANG , Laura Ellen West , Thomas ZABAWA , Junping ZHAO
发明人: Jeremy Lee BARYZA , Rohan Eric John BECKWITH , Keith BOWMAN , Crystal BYERS , Tanzina FAZAL , Gabriel Grant GAMBER , Cameron Chuck-munn LEE , Ritesh Bhanudasji TICHKULE , Chandra VARGEESE , Shuangxi WANG , Laura Ellen West , Thomas ZABAWA , Junping ZHAO
IPC分类号: A61K47/18 , A61K47/12 , A61K47/14 , C12N15/113 , A61K47/22
CPC分类号: A61K47/18 , A61K9/1271 , A61K9/1272 , A61K47/183 , A61K47/22 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/22 , C07C219/28 , C07C229/12 , C07C235/46 , C07C237/08 , C07D205/04 , C07D213/69 , C07D213/79 , C07D295/096 , C07D317/24 , C07D317/28 , C12N15/1137 , C12N2310/14 , C12N2320/32
摘要: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
摘要翻译: 本发明提供式(I)化合物或其药学上可接受的盐,其中R 1 -R 4,L和X如本文所定义。 式(I)化合物及其药学上可接受的盐是可用于将生物活性剂递送至细胞和组织的阳离子脂质。
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公开(公告)号:US20160317458A1
公开(公告)日:2016-11-03
申请号:US15104723
申请日:2014-12-17
申请人: Luis Brito , Delai Chen , Gabriel Grant Gamber , Andrew Geall , Kevin Love , Thomas Zabawa , Frederic Zecri
发明人: Luis Brito , Delai Chen , Gabriel Grant Gamber , Andrew Geall , Kevin Love , Thomas Zabawa , Frederic Zecri
IPC分类号: A61K9/51 , C07C219/06 , C07D211/62 , C07C229/12 , C07C323/52 , C07C235/08 , C07D211/06 , C07D295/13 , C07D211/22 , C07D207/16 , C07D319/06 , C07D207/12 , C07D211/46 , C07D233/64 , A61K9/127 , A61K38/22 , A61K38/18 , A61K39/12 , C12N7/00 , C12N15/113
CPC分类号: A61K9/5123 , A61K9/1272 , A61K31/7105 , A61K31/713 , A61K38/1816 , A61K38/2264 , A61K39/12 , A61K47/18 , A61K2039/53 , C07C219/06 , C07C219/16 , C07C229/12 , C07C235/08 , C07C323/52 , C07D207/12 , C07D207/16 , C07D211/06 , C07D211/22 , C07D211/46 , C07D211/62 , C07D233/60 , C07D233/64 , C07D295/088 , C07D295/13 , C07D319/06 , C12N7/00 , C12N15/1137 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2760/00034 , C12N2760/00071
摘要: This invention provides for a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1-R3, n, p, L1 and L2 are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号:US20160108025A1
公开(公告)日:2016-04-21
申请号:US14983741
申请日:2015-12-30
申请人: Gregory Raymond Bebernitz , Emma Cody , Tajesh Patel , Ming Qian , Lewis Whitehead , Thomas Zabawa , Frederic Zecri
发明人: Gregory Raymond Bebernitz , Emma Cody , Tajesh Patel , Ming Qian , Lewis Whitehead , Thomas Zabawa , Frederic Zecri
IPC分类号: C07D405/04 , C07D405/14 , C07D307/85 , A61K31/343 , C07D407/12 , A61K31/36 , A61K31/357 , A61K31/5377 , C07D405/12 , A61K31/443 , C07D417/12 , A61K31/428 , A61K31/4439 , C07D417/14 , A61K31/41
CPC分类号: C07D405/04 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/41 , A61K31/428 , A61K31/443 , A61K31/4439 , A61K31/5377 , C07D307/85 , C07D405/12 , C07D405/14 , C07D407/12 , C07D417/12 , C07D417/14
摘要: The present invention provides a compound of formula I, in which R1, R2, X and R3 are defined in the Summary of the Invention, or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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7.
公开(公告)号:US20160106842A1
公开(公告)日:2016-04-21
申请号:US14779939
申请日:2014-03-06
申请人: Jeremy Lee BARYZA , Rohan Eric John BECKWITH , Keith BOWMAN , Crystal BYERS , Tanzina FAZAL , Gabriel Grant GAMBER , Cameron Chuck-Munn LEE , Ritesh Bhanudasji TICHKULE , Chandra VARGEESE , Shuangxi WANG , Laura WEST , Thomas ZABAWA , Junping ZHAO
发明人: Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-Munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura West , Thomas Zabawa , Junping Zhao
IPC分类号: A61K47/18 , C12N15/113 , A61K38/22 , C07D295/096 , C07D205/04 , C07C235/42 , A61K47/22 , C07C229/14 , C07C229/12 , C07D213/79 , C07D213/69 , C07C217/58 , C07D317/28
CPC分类号: A61K47/18 , A61K9/0019 , A61K9/1272 , A61K9/5123 , A61K31/713 , A61K38/2264 , A61K47/22 , A61K48/00 , C07C217/58 , C07C219/06 , C07C229/12 , C07C229/14 , C07C235/42 , C07D205/04 , C07D213/69 , C07D213/79 , C07D295/096 , C07D317/28 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
摘要翻译: 本发明提供式(I)化合物或其药学上可接受的盐,其中R 1 -R 4,L和X如本文所定义。 式(I)化合物及其药学上可接受的盐是可用于将生物活性剂递送至细胞和组织的阳离子脂质。
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公开(公告)号:US09255093B2
公开(公告)日:2016-02-09
申请号:US14688397
申请日:2015-04-16
申请人: Gregory Raymond Bebernitz , Emma Cody , Tajesh Patel , Ming Qian , Lewis Whitehead , Thomas Zabawa , Frederic Zecri
发明人: Gregory Raymond Bebernitz , Emma Cody , Tajesh Patel , Ming Qian , Lewis Whitehead , Thomas Zabawa , Frederic Zecri
IPC分类号: C07D405/04 , A61K31/41 , C07D417/12 , C07D405/14 , C07D307/85 , A61K31/343 , C07D407/12 , A61K31/357 , A61K31/443 , A61K31/428
CPC分类号: C07D405/04 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/41 , A61K31/428 , A61K31/443 , A61K31/4439 , A61K31/5377 , C07D307/85 , C07D405/12 , C07D405/14 , C07D407/12 , C07D417/12 , C07D417/14
摘要: The present invention provides a compound of formula I, in which R1, R2, X and R3 are defined in the Summary of the Invention, or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译: 本发明提供式I化合物或其药学上可接受的盐,其中R 1,R 2,X和R 3在发明概述中定义。 制备本发明化合物的方法及其治疗用途。 本发明还提供药理活性剂和药物组合物的组合。
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公开(公告)号:US10059655B2
公开(公告)日:2018-08-28
申请号:US15104736
申请日:2014-12-17
申请人: Luis Brito , Delai Chen , Gabriel Grant Gamber , Andrew Geall , Kevin Love , Thomas Zabawa , Frederic Zecri
发明人: Luis Brito , Delai Chen , Gabriel Grant Gamber , Andrew Geall , Kevin Love , Thomas Zabawa , Frederic Zecri
IPC分类号: C07C229/12 , C07C229/38 , C07D205/04 , C07D265/30 , C07D207/12 , C07D207/16 , C07D211/22 , C07D295/088 , C07D211/46 , C07D211/60 , C07D211/62 , C07D295/15 , C07C271/20 , C07C219/04 , A61K47/18 , A61K9/127 , A61K9/51 , A61K31/7105 , A61K31/713 , A61K39/39 , C07C271/22 , C07D211/06 , C07D211/34 , C07D211/44
CPC分类号: C07C229/12 , A61K9/1272 , A61K9/5123 , A61K31/7105 , A61K31/713 , A61K39/12 , A61K39/39 , A61K47/18 , A61K2039/53 , A61K2039/55555 , C07C219/04 , C07C229/38 , C07C271/20 , C07C271/22 , C07D205/04 , C07D207/12 , C07D207/16 , C07D211/06 , C07D211/22 , C07D211/34 , C07D211/44 , C07D211/46 , C07D211/60 , C07D211/62 , C07D265/30 , C07D295/088 , C07D295/15 , C12N2760/18534
摘要: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, n and p are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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公开(公告)号:US20170196979A1
公开(公告)日:2017-07-13
申请号:US15277402
申请日:2016-09-27
申请人: Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
发明人: Jeremy Lee Baryza , Rohan Eric John Beckwith , Keith Bowman , Crystal Byers , Tanzina Fazal , Gabriel Grant Gamber , Cameron Chuck-munn Lee , Ritesh Bhanudasji Tichkule , Chandra Vargeese , Shuangxi Wang , Laura Ellen West , Thomas Zabawa , Junping Zhao
IPC分类号: A61K47/18 , C12N15/113 , A61K47/22
CPC分类号: A61K47/18 , A61K9/1271 , A61K9/1272 , A61K47/183 , A61K47/22 , C07C217/58 , C07C217/60 , C07C217/62 , C07C219/22 , C07C219/28 , C07C229/12 , C07C235/46 , C07C237/08 , C07D205/04 , C07D213/69 , C07D213/79 , C07D295/096 , C07D317/24 , C07D317/28 , C12N15/1137 , C12N2310/14 , C12N2320/32
摘要: This invention provides for a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1-R4, L and X are defined herein. The compounds of formula (I) and pharmaceutically acceptable salts thereof are cationic lipids useful in the delivery of biologically active agents to cells and tissues.
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