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公开(公告)号：US08080553B2
公开(公告)日：2011-12-20
申请号：US11517593
申请日：2006-09-07
申请人： Curtis Keith , Alexis Borisy , Grant R. Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley , Michael S. Slavonic , Brendan Smith , Benjamin A. Auspitz
发明人： Curtis Keith , Alexis Borisy , Grant R. Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley , Michael S. Slavonic , Brendan Smith , Benjamin A. Auspitz
IPC分类号： A01N43/54 , A01N43/90 , A61K31/517 , A61K31/519 , C07D239/42 , C07D401/04
CPC分类号： A61K31/565 , A61K9/0073 , A61K9/209 , A61K31/519 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
摘要翻译： 本发明的特征在于一种通过向患者施用四取代的嘧啶并嘧啶，单独或与一种或多种另外的试剂组合来治疗诊断患有或有风险发展免疫炎性疾病的患者的方法。 本发明还特征在于含有四取代的嘧啶并嘧啶与一种或多种另外的试剂组合的组合物。
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2.发明申请公开(公告)号：US20120058979A1
公开(公告)日：2012-03-08
申请号：US13292669
申请日：2011-11-09
申请人： Curtis Keith , Alexis Borisy , Grant R. Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley , Michael S. Slavonic , Brendan Smith , Benjamin A. Auspitz
发明人： Curtis Keith , Alexis Borisy , Grant R. Zimmermann , Edward Roydon Jost-Price , Palaniyandi Manivasakam , Nicole Hurst , Michael A. Foley , Michael S. Slavonic , Brendan Smith , Benjamin A. Auspitz
IPC分类号： A61K31/573 , A61P37/06 , A61K31/575 , A61K31/568 , A61K31/58 , A61K31/57
CPC分类号： A61K31/565 , A61K9/0073 , A61K9/209 , A61K31/519 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
摘要翻译： 本发明的特征在于一种通过向患者施用四取代的嘧啶并嘧啶，单独或与一种或多种另外的试剂组合来治疗诊断患有或有发展为免疫炎性疾病风险的患者的方法。 本发明还特征在于含有四取代的嘧啶并嘧啶与一种或多种另外的试剂组合的组合物。
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公开(公告)号：US20090075951A1
公开(公告)日：2009-03-19
申请号：US12275134
申请日：2008-11-20
申请人： Benjamin A. Auspitz , Alexis Borisy , Jason Fong , Nicole Hurst , Edward Roydon Jost-Price , Curtis T. Keith , Palaniyandi Manivasakam , Robyn Sackeyfio , Michael S. Slavonic , Brendan Smith , Grant R. Zimmermann
发明人： Benjamin A. Auspitz , Alexis Borisy , Jason Fong , Nicole Hurst , Edward Roydon Jost-Price , Curtis T. Keith , Palaniyandi Manivasakam , Robyn Sackeyfio , Michael S. Slavonic , Brendan Smith , Grant R. Zimmermann
IPC分类号： A61K31/60 , A61K31/573
CPC分类号： A61K45/06 , A61K31/565 , A61K38/13 , A61K2300/00
摘要： The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a tricyclic compound and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing a tricyclic compound and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
摘要翻译： 本发明的特征在于一种通过向患者施用三环化合物和任选的皮质类固醇或其它化合物来治疗被诊断患有免疫炎症疾病或有风险的患者的方法。 本发明还特征在于含有三环化合物和皮质类固醇或其它化合物的药物组合物，用于治疗或预防免疫炎性疾病。
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公开(公告)号：US20100210606A1
公开(公告)日：2010-08-19
申请号：US12772693
申请日：2010-05-03
申请人： Edward Roydon Jost-Price , Palaniyandi Manivasakam , Brendan Smith , Michael S. Slavonic , Benjamin A. Auspitz
发明人： Edward Roydon Jost-Price , Palaniyandi Manivasakam , Brendan Smith , Michael S. Slavonic , Benjamin A. Auspitz
CPC分类号： A61K45/06 , A61K31/415 , A61K31/56 , A61K2300/00
摘要： The invention features a method for treating an immunoinflammatory administering a compound of formula (I), e.g., ibudilast or KC-764, alone or in combination with a corticosteroid, tetra-substituted pyrimidopyrimidine, or other compound. The invention also features pharmaceutical compositions including the combination above for the treatment or prevention of an immunoinflammatory disorder.
摘要翻译： 本发明的特征在于一种方法，用于单独或与皮质类固醇，四取代嘧啶并嘧啶或其它化合物组合施用式（I）化合物，例如异丁司特或KC-764的免疫炎症的方法。 本发明还包括药物组合物，包括上述用于治疗或预防免疫炎性疾病的组合。
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公开(公告)号：US07709495B2
公开(公告)日：2010-05-04
申请号：US10992878
申请日：2004-11-19
申请人： Edward Roydon Jost-Price , Palaniyandi Manivasakam , Brendan Smith , Michael S. Slavonic , Benjamin A. Auspitz
发明人： Edward Roydon Jost-Price , Palaniyandi Manivasakam , Brendan Smith , Michael S. Slavonic , Benjamin A. Auspitz
CPC分类号： A61K45/06 , A61K31/415 , A61K31/56 , A61K2300/00
摘要： The invention features a method for treating an immunoinflammatory administering a compound of formula (I), e.g., ibudilast or KC-764, alone or in combination with a corticosteroid, tetra-substituted pyrimidopyrimidine, or other compound. The invention also features pharmaceutical compositions including the combination above for the treatment or prevention of an immunoinflammatory disorder.
摘要翻译： 本发明的特征在于一种方法，用于单独或与皮质类固醇，四取代嘧啶并嘧啶或其它化合物组合施用式（I）化合物，例如异丁司特或KC-764的免疫炎症的方法。 本发明还包括药物组合物，包括上述用于治疗或预防免疫炎性疾病的组合。
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