公开(公告)号：US11981644B2

公开(公告)日：2024-05-14

申请号：US17453761

申请日：2021-11-05

申请人： Cytokinetics, Inc.

发明人： Bradley P. Morgan ,  Chris Evans ,  Pu-Ping Lu ,  Makoto Yamasaki ,  Wenyue Wang ,  Scott Collibee ,  Takuya Makino ,  Kazuyuki Tsuchiya ,  Toshio Kurosaki ,  Susumu Yamaki ,  Eriko Honjo ,  Yuka Koizumi ,  Naoto Katoh ,  Ryuichi Sekioka ,  Ikumi Kuriwaki

IPC分类号： C07D243/14 ,  C07D401/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/08 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D498/04 ,  C07D519/00

CPC分类号： C07D243/14 ,  C07D401/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/08 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04 ,  C07D498/04 ,  C07D519/00 ,  C07B2200/13

摘要： Provided herein are compounds of formula (1):




or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein. Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.

公开(公告)号：US20230083960A1

公开(公告)日：2023-03-16

申请号：US17453761

申请日：2021-11-05

申请人： Cytokinetics, Inc.

发明人： Bradley P. MORGAN ,  Chris Evans ,  Pu-Ping Lu ,  Makoto Yamasaki ,  Wenyue Wang ,  Scott Collibee ,  Takuya Makino ,  Kazuyuki Tsuchiya ,  Toshio Kurosaki ,  Susumu Yamaki ,  Eriko Honjo ,  Yuka Koizumi ,  Naoto Katoh ,  Ryuichi Sekioka ,  Ikumi Kuriwaki ,  Denise Andersen

IPC分类号： C07D243/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D405/14 ,  C07D401/12 ,  C07D403/14 ,  C07D519/00 ,  C07D413/12 ,  C07D471/10 ,  C07D417/12 ,  C07D413/08

摘要： Provided herein are compounds of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, Ry, Rz, R1, R2, R3, and R4 are as defined herein.
Also provided herein is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing.
Also provided herein are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, to treat various diseases, disorders, and conditions responsive to the modulation of the contractility of the skeletal sarcomere.