公开(公告)号：US20140296569A1

公开(公告)日：2014-10-02

申请号：US14300924

申请日：2014-06-10

Applicant: Daiichi Sankyo Company, Limited

Inventor： Yoshitaka NAKAMURA ,  Takafumi KITAWAKI ,  Takeshi KANEDA

IPC: C07C45/80 ,  C07C227/12

CPC classification number: C07C45/80 ,  C07B57/00 ,  C07B2200/07 ,  C07C45/85 ,  C07C227/12 ,  C07C227/30 ,  C07C2602/20 ,  C07C49/627 ,  C07C229/32

Abstract: An optically active bicyclic compound is efficiently produced by optical resolution using an optically active amine.

Abstract translation: 通过使用光学活性胺的光学拆分有效地制备光学活性双环化合物。

公开(公告)号：US20200062765A1

公开(公告)日：2020-02-27

申请号：US16494116

申请日：2018-03-13

Applicant: DAIICHI SANKYO COMPANY, LIMITED

Inventor： Ryoji KOIKE ,  Yoshifumi HACHISU ,  Takafumi KITAWAKI ,  Shohei SHIRAISHI

IPC: C07D487/04

Abstract: Provided is a novel and industrially useful method for producing a 3, 6-disubstituted imidazo[1, 2-b]pyridazine derivative. The present invention provides a method for producing a 3, 6-disubstituted imidazo[1, 2-b]pyridazine derivative, which uses 6-fluoroimidazo[1, 2-b]pyridazine as a starting material, while using an aromatic substitution reaction that utilizes C—H activation by means of palladium.

公开(公告)号：US20150218123A1

公开(公告)日：2015-08-06

申请号：US14615972

申请日：2015-02-06

Applicant: DAIICHI SANKYO COMPANY, LIMITED

Inventor： Yoshitaka NAKAMURA ,  Kazutoshi UKAI ,  Takafumi KITAWAKI ,  Takumi NAKAJIMA ,  Yutaka KITAGAWA ,  Yukito FURUYA ,  Makoto IMAI ,  Eiji NUMAGAMI ,  Masakazu WAKAYAMA ,  Ayako SAITO

IPC: C07D319/06 ,  C07C67/00 ,  C07C255/47 ,  C07C229/32 ,  C07C205/50 ,  C07C201/12 ,  C07C227/04 ,  C07C69/608 ,  C07C253/00

CPC classification number: C07D319/06 ,  C07B2200/07 ,  C07C67/00 ,  C07C67/343 ,  C07C69/608 ,  C07C201/12 ,  C07C201/16 ,  C07C205/50 ,  C07C211/27 ,  C07C227/04 ,  C07C227/42 ,  C07C229/32 ,  C07C253/00 ,  C07C253/10 ,  C07C253/30 ,  C07C253/34 ,  C07C255/47 ,  C07C2602/20

Abstract: An object of the present invention is to provide an optically active bicyclic γ-amino acid derivative in a high purity. The object can be attained by a mixture of compounds represented by the general formulas (I) and (I′), or a method for producing a compound represented by the general formula (VII) or a salt thereof via the compound (I): wherein R1 and R2 each represent a C1-6 alkyl group or the like; and R3 represents a cyano group or the like,

Abstract translation: 本发明的目的是提供高纯度的光学双环γ-氨基酸衍生物。 该目的可以通过由通式（I）和（I'）表示的化合物的混合物或通过化合物（I）制备由通式（VII）表示的化合物或其盐的方法来实现： 其中R1和R2各自表示C1-6烷基等; R3表示氰基等，