公开(公告)号：US20220409540A1

公开(公告)日：2022-12-29

申请号：US17776743

申请日：2020-11-13

申请人： DAIICHI SANKYO COMPANY, LIMITED ,  NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRTION

发明人： Takako NIWA ,  Takashi SUZUKI ,  Makoto KOIZUMI ,  Nao JONAI ,  Yoshikuni ONODERA ,  Fumihiko TAKESHITA ,  Ken ISHII

IPC分类号： A61K9/16 ,  A61K39/12

摘要： The present invention provides a vaccine for preventing and/or treating infections with human papillomavirus. The present invention relates to a lipid particle encapsulating a nucleic acid molecule capable of expressing the E6 and E7 antigens of human papillomavirus, wherein the lipid comprises a cationic lipid represented by general formula (Ia) or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each independently represent a C1-C3 alkyl group; L1 represents a C17-C19 alkenyl group which may have one or a plurality of C2-C4 alkanoyloxy groups; L2 represents a C10-C19 alkyl group which may have one or a plurality of C2-C4 alkanoyloxy groups or a C10-C19 alkenyl group which may have one or a plurality of C2-C4 alkanoyloxy groups; and p is 3 or 4.

公开(公告)号：US20180148436A2

公开(公告)日：2018-05-31

申请号：US15036981

申请日：2015-07-06

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Noriyasu HAGINOYA ,  Takashi SUZUKI ,  Miho HAYAKAWA ,  Masahiro OTA ,  Tomoharu TSUKADA ,  Katsuhiro KOBAYASHI ,  Yosuke ANDO ,  Takeshi JIMBO ,  Koichi NAKAMURA

IPC分类号： C07D409/14 ,  C07D405/14 ,  C07C309/04 ,  C07B59/00 ,  C07C309/35

CPC分类号： C07D409/14 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  C07B59/002 ,  C07B2200/05 ,  C07B2200/13 ,  C07C309/04 ,  C07C309/35 ,  C07D405/14

摘要： The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.The present disclosure provides pyridone derivatives having a tetrahydropyranylmethyl group represented by the following formula (I) having various substituents, or salts thereof, or crystals of the compounds or the salts, wherein R1, R2, R3, R4, R5, W, X, Y, and Z are each as defined in the specification:

公开(公告)号：US20170183329A1

公开(公告)日：2017-06-29

申请号：US15036981

申请日：2015-07-06

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Noriyasu HAGINOYA ,  Takashi SUZUKI ,  Miho HAYAKAWA ,  Masahiro OTA ,  Tomoharu TSUKADA ,  Katsuhiro KOBAYASHI ,  Yosuke ANDO ,  Takeshi JIMBO ,  Koichi NAKAMURA

IPC分类号： C07D409/14 ,  C07C309/35 ,  C07B59/00 ,  C07D405/14 ,  C07C309/04

CPC分类号： C07D409/14 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5377 ,  C07B59/002 ,  C07B2200/05 ,  C07B2200/13 ,  C07C309/04 ,  C07C309/35 ,  C07D405/14

摘要： The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.The present disclosure provides pyridone derivatives having a tetrahydropyranylmethyl group represented by the following formula (I) having various substituents, or salts thereof, or crystals of the compounds or the salts, wherein R1, R2, R3, R4, R5, W, X, Y, and Z are each as defined in the specification:

公开(公告)号：US20200010458A1

公开(公告)日：2020-01-09

申请号：US16575177

申请日：2019-09-18

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Noriyasu HAGINOYA ,  Takashi SUZUKI ,  Miho HAYAKAWA ,  Masahiro OTA ,  Tomoharu TSUKADA ,  Katsuhiro KOBAYASHI ,  Yosuke ANDO ,  Takeshi JIMBO ,  Koichi NAKAMURA

IPC分类号： C07D409/14 ,  C07D405/14 ,  C07B59/00 ,  C07C309/04 ,  C07C309/35

摘要： The present disclosure provides novel compounds or salts thereof, or crystals of the compounds or the salts, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.The present disclosure provides pyridone derivatives having a tetrahydropyranylmethyl group represented by the following formula (I) having various substituents, or salts thereof, or crystals of the compounds or the salts, wherein R1, R2, R3, R4, R5, W, X, Y, and Z are each as defined in the specification:

公开(公告)号：US20220002277A1

公开(公告)日：2022-01-06

申请号：US17400795

申请日：2021-08-12

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Noriyasu HAGINOYA ,  Takashi SUZUKI ,  Miho HAYAKAWA ,  Masahiro OTA ,  Tomoharu TSUKADA ,  Katsuhiro KOBAYASHI ,  Yosuke ANDO ,  Takeshi JIMBO ,  Koichi NAKAMURA

IPC分类号： C07D409/14 ,  C07D405/14 ,  A61K31/496 ,  A61K31/497 ,  A61K31/444 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/501 ,  C07B59/00 ,  C07C309/04 ,  C07C309/35

摘要： It is intended to provide a novel compound or a salt thereof, or crystals of the compound or the salt, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.
[Solution]
The present invention provides a pyridone derivative having a tetrahydropyranylmethyl group represented by the following formula (I) having various substituents, or a salt thereof, or crystals of the compound or the salt (wherein R1, R2, R3, R4, R5, W, X, Y, and Z are each as defined in the specification).