公开(公告)号：US20220409540A1

公开(公告)日：2022-12-29

申请号：US17776743

申请日：2020-11-13

申请人： DAIICHI SANKYO COMPANY, LIMITED ,  NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRTION

发明人： Takako NIWA ,  Takashi SUZUKI ,  Makoto KOIZUMI ,  Nao JONAI ,  Yoshikuni ONODERA ,  Fumihiko TAKESHITA ,  Ken ISHII

IPC分类号： A61K9/16 ,  A61K39/12

摘要： The present invention provides a vaccine for preventing and/or treating infections with human papillomavirus. The present invention relates to a lipid particle encapsulating a nucleic acid molecule capable of expressing the E6 and E7 antigens of human papillomavirus, wherein the lipid comprises a cationic lipid represented by general formula (Ia) or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each independently represent a C1-C3 alkyl group; L1 represents a C17-C19 alkenyl group which may have one or a plurality of C2-C4 alkanoyloxy groups; L2 represents a C10-C19 alkyl group which may have one or a plurality of C2-C4 alkanoyloxy groups or a C10-C19 alkenyl group which may have one or a plurality of C2-C4 alkanoyloxy groups; and p is 3 or 4.

公开(公告)号：US20200080086A1

公开(公告)日：2020-03-12

申请号：US16692284

申请日：2019-11-22

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Makoto KOIZUMI ,  Yoshiyuki ONISHI ,  Takako NIWA ,  Masakazu TAMURA ,  Yuji KASUYA

IPC分类号： C12N15/113 ,  A61K48/00 ,  A61K47/44 ,  A61K47/28 ,  A61K47/22 ,  A61K47/18 ,  A61K9/127 ,  A61K9/10 ,  A61K47/54 ,  C12N15/11 ,  C07D211/46 ,  C07D211/22 ,  C07C219/16 ,  A61K31/713 ,  A61K31/7088

摘要： The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.

公开(公告)号：US20160257951A1

公开(公告)日：2016-09-08

申请号：US14903711

申请日：2014-07-07

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Makoto KOIZUMI ,  Yoshiyuki ONISHI ,  Takako NIWA ,  Masakazu TAMURA ,  Yuji KASUYA

IPC分类号： C12N15/113 ,  A61K9/10 ,  A61K47/28 ,  A61K48/00 ,  C07D211/46 ,  A61K47/18 ,  A61K47/22 ,  A61K9/127 ,  A61K47/44 ,  C07C219/16

CPC分类号： C12N15/113 ,  A61K9/10 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  A61K47/44 ,  A61K47/543 ,  A61K48/0008 ,  A61K48/005 ,  C07C219/16 ,  C07D211/22 ,  C07D211/46 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/32

摘要： The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.

摘要翻译： 本发明提供由式（Ia）表示的化合物作为形成脂质颗粒的新型阳离子脂质，并且还提供包含该化合物的脂质颗粒。 本发明还提供含有脂质颗粒的核酸脂质颗粒和含有核酸脂质颗粒作为活性成分的药物组合物。

公开(公告)号：US20190112606A1

公开(公告)日：2019-04-18

申请号：US16227902

申请日：2018-12-20

申请人： NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION ,  DAIICHI SANKYO COMPANY, LIMITED

发明人： Ken ISHII ,  Kouji KOBIYAMA ,  Taiki AOSHI ,  Fumihiko TAKESHITA ,  Yuji KASUYA ,  Takako NIWA ,  Makoto KOIZUMI

IPC分类号： C12N15/117 ,  A61K31/7125 ,  C12N7/00 ,  A61K39/145 ,  A61K39/155 ,  A61K39/39 ,  A61K31/713 ,  C07H21/04 ,  A61K39/12 ,  C08B37/00

摘要： The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3′-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and β-1,3-glucan.

公开(公告)号：US20180051285A1

公开(公告)日：2018-02-22

申请号：US15797824

申请日：2017-10-30

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Makoto KOIZUMI ,  Yoshiyuki ONISHI ,  Takako NIWA ,  Masakazu TAMURA ,  Yuji KASUYA

IPC分类号： C12N15/113 ,  A61K47/54 ,  A61K9/127 ,  A61K47/44 ,  A61K48/00 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  C07D211/46 ,  C07D211/22 ,  C07C219/16 ,  A61K31/713 ,  A61K31/7088 ,  C12N15/11 ,  A61K9/10

CPC分类号： C12N15/113 ,  A61K9/10 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  A61K47/44 ,  A61K47/543 ,  A61K48/0008 ,  A61K48/005 ,  C07C219/16 ,  C07D211/22 ,  C07D211/46 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/32

摘要： The present invention provides a compound represented by the formula (Ia) as a novel cationic lipid that forms a lipid particle and also provides a lipid particle comprising the compound. The present invention further provides a nucleic acid lipid particle containing the lipid particle, and a pharmaceutical composition containing the nucleic acid lipid particle as an active ingredient.

公开(公告)号：US20160208260A1

公开(公告)日：2016-07-21

申请号：US15022856

申请日：2014-09-19

申请人： NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEAL TH AND NUTRITION ,  DAIICHI SANKYO COMPANY, LIMITED

发明人： Ken ISHII ,  Kouji KOBIYAMA ,  Taiki AOSHI ,  Fumihiko TAKESHITA ,  Yuji KASUYA ,  Takako NIWA ,  Makoto KOIZUMI

IPC分类号： C12N15/117 ,  C08B37/00 ,  C12N7/00 ,  A61K39/145 ,  A61K39/155 ,  C07H21/04 ,  A61K39/39

CPC分类号： C12N15/117 ,  A61K31/7125 ,  A61K31/713 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/55561 ,  A61K2039/55583 ,  C07H21/04 ,  C08B37/0024 ,  C12N7/00 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2310/351 ,  C12N2310/3519 ,  C12N2320/31 ,  C12N2760/16134 ,  C12N2760/18534

摘要： The present invention provides an oligodeoxynucleotide containing humanized K type CpG oligodeoxynucleotide and poly deoxyadenylate, wherein the poly deoxyadenylate is placed on the 3′-side of the humanized K type CpG oligodeoxynucleotide. In addition, the present invention provides a complex containing the aforementioned oligodeoxynucleotide and β-1,3-glucan.

摘要翻译： 本发明提供了含有人源化K型CpG寡脱氧核苷酸和聚脱氧腺苷酸的寡脱氧核苷酸，其中所述聚脱氧腺苷酸位于人源化K型CpG寡脱氧核苷酸的3'侧。 此外，本发明提供含有上述寡脱氧核苷酸和β-葡聚糖的复合物。