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公开(公告)号：US11584746B2
公开(公告)日：2023-02-21
申请号：US16970931
申请日：2019-02-20
发明人： Nathanael S. Gray , Dries De Clercq , Jaebong Jang , Pasi Janne , Ciric To , Michael Eck , Eunyoung Park , David Heppner
IPC分类号： C07D471/04 , C07D243/38 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D417/14
摘要： The application relates to a compound having Formula Ia or Ib: or a pharmaceutically acceptable salt, hydrate, or solvate thereof, which modulates the activity of EGFR, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which EGFR plays a role.
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公开(公告)号：US20230406838A1
公开(公告)日：2023-12-21
申请号：US18189092
申请日：2023-03-23
IPC分类号： C07D401/04 , C07D409/14 , C07D401/14 , C07D405/14 , C07D403/12 , C07D233/84 , A61P35/00
CPC分类号： C07D401/04 , C07D409/14 , C07D401/14 , C07D405/14 , C07D403/12 , C07D233/84 , A61P35/00
摘要： The disclosure relates to compounds that act as inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.
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公开(公告)号：US20220378757A1
公开(公告)日：2022-12-01
申请号：US17596720
申请日：2020-06-19
发明人： Courtney A. Cullis , Krista E. Gipson , Yongbo Hu , Shih-Chung Huang , Nathanael S. Gray , David A. Scott , Thomas Gero , David Heppner , Tyler Beyett , Ciric To , Michael Eck
IPC分类号： A61K31/437 , A61K39/395 , A61K31/506 , C07D471/04 , A61K31/444 , A61K31/496
摘要： The disclosure relates to a compound of Formula (I), which acts as an allosteric inhibitor of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compound; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.
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公开(公告)号：US20230212171A1
公开(公告)日：2023-07-06
申请号：US18000722
申请日：2021-06-09
申请人： David A. SCOTT , Thomas GERO , Tyler BEYETT , David HEPPNER , Krista E. GIPSON , Shih-Chung HUANG , Steve STROUD , Dana-Farber Cancer Institute, Inc.
发明人： David A. Scott , Thomas Gero , Tyler Beyett , David Heppner , Krista E. Gipson , Shih-Chung Huang , Steve Stroud
IPC分类号： C07D487/04 , C07D495/04 , C07D513/04 , C07D401/14 , A61K45/06
CPC分类号： C07D487/04 , A61K45/06 , C07D401/14 , C07D495/04 , C07D513/04 , C07B2200/05
摘要： The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.
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公开(公告)号：US20220411404A1
公开(公告)日：2022-12-29
申请号：US17741206
申请日：2022-05-10
发明人： David A. Scott , David Heppner , Thomas Gero , Courtney A. Cullis , Ciric To , Shih-Chung Huang , Yongbo Hu , Steve Stroud , Tyler Beyett , Michael Eck , Nathanael S. Gray
IPC分类号： C07D401/14 , C07D471/04 , C07D473/00 , C07D495/14
摘要： The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.
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公开(公告)号：US20220233545A1
公开(公告)日：2022-07-28
申请号：US17596639
申请日：2020-06-19
发明人： Nathanael S. Gray , David A. Scott , Thomas Gero , Michael Eck , David Heppner , Tyler Beyett , Ciric To
IPC分类号： A61K31/519 , C07D417/12 , C07D403/12 , C07D417/14 , C07D403/14 , C07D471/04 , A61K39/395 , A61K31/506 , A61P35/00 , C07D401/12 , C07D401/10 , C07D401/14 , A61K31/517 , A61K31/4725 , A61K31/502 , A61K31/496 , A61K31/5377
摘要： The disclosure relates to compounds that act as an allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.
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