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公开(公告)号：US20230174998A1
公开(公告)日：2023-06-08
申请号：US17919435
申请日：2021-04-09
申请人： DANISCO US INC.
发明人： Yun Luo , Igor Nikolaev , Robert James Pratt, II
CPC分类号： C12N15/80 , C12N1/14 , C07K14/37 , C12N9/2437 , C12R2001/885
摘要： The present disclosure is generally related to mutant and genetically modified filamentous fungal cells and methods thereof for use in the production of proteins of interest. More particularly, as described herein, the mutant and/or modified fungal cells (strains) of the disclosure are well-suited for use in industrial scale fermentation processes for the enhanced expression/production of proteins of interest in the absence and/or in the presence of an inducing substrate.
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公开(公告)号：US11976266B2
公开(公告)日：2024-05-07
申请号：US17042308
申请日：2019-04-16
申请人： DANISCO US INC.
摘要： The present strains and methods of the disclosure relate to genetic modifications in filamentous fungi that give rise to variant strains having altered phenotypes, altered morphologies, altered growth characteristics, and the like. More specifically, as presented and described herein, such variant strains of filamentous fungi comprising reduced viscosity phenotypes are well-suited for growth in submerged cultures (e.g., for the large-scale production of enzymes and other proteins or metabolites for commercial applications).
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公开(公告)号：US12116605B2
公开(公告)日：2024-10-15
申请号：US17264061
申请日：2019-07-25
申请人： DANISCO US INC
IPC分类号： C12N9/34
CPC分类号： C12N9/2428 , C12Y302/01003
摘要： The present strains and methods of the disclosure relate to genetic modifications in filamentous fungi that give rise to variant strains of filamentous fungi comprising enhanced protein productivity phenotypes. More specifically, as presented, described and exemplified herein, such variant strains of filamentous fungi comprising enhanced protein productivity phenotypes are well-suited for growth in submerged cultures, such as in large-scale production of proteins of interest for commercial applications.
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