公开(公告)号：US12116605B2

公开(公告)日：2024-10-15

申请号：US17264061

申请日：2019-07-25

申请人： DANISCO US INC

发明人： Robert James Pratt, II

IPC分类号： C12N9/34

CPC分类号： C12N9/2428 ,  C12Y302/01003

摘要： The present strains and methods of the disclosure relate to genetic modifications in filamentous fungi that give rise to variant strains of filamentous fungi comprising enhanced protein productivity phenotypes. More specifically, as presented, described and exemplified herein, such variant strains of filamentous fungi comprising enhanced protein productivity phenotypes are well-suited for growth in submerged cultures, such as in large-scale production of proteins of interest for commercial applications.

公开(公告)号：US12098409B2

公开(公告)日：2024-09-24

申请号：US17983665

申请日：2022-11-09

申请人： TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED

发明人： Yechezkel Kashi ,  Inbar Kesten ,  Keren Buhnik-Rosenblau

IPC分类号： C12P7/10 ,  C12N1/16 ,  C12N1/18 ,  C12N1/20 ,  C12N9/28 ,  C12N9/34 ,  C12N9/42 ,  C12N9/54 ,  C12P7/06 ,  C12R1/07 ,  C12R1/38 ,  C12R1/84 ,  C12R1/85

CPC分类号： C12P7/10 ,  C12N9/2417 ,  C12N9/2428 ,  C12N9/2437 ,  C12N9/54 ,  C12P7/065 ,  C12N1/165 ,  C12N1/185 ,  C12N1/205 ,  C12P2203/00 ,  C12R2001/07 ,  C12R2001/38 ,  C12R2001/84 ,  C12R2001/85 ,  C12Y302/01001 ,  C12Y302/01003 ,  C12Y302/01004

摘要： The present invention is directed to compositions comprising hydrolase-secreting bacteria and fermenting microorganisms and use thereof, such as for fermentative production of ethanol.

公开(公告)号：US11959119B2

公开(公告)日：2024-04-16

申请号：US17384003

申请日：2021-07-23

申请人： POET Research, Inc.

发明人： Cory James Sarks ,  Malgorzata M. Slupska ,  David Charles Carlson ,  Benjamin M. Gerdes ,  Neelakantam V. Narendranath ,  David D. Bushong

IPC分类号： C12P7/06 ,  C12M1/00 ,  C12N1/18 ,  C12N9/26

CPC分类号： C12P7/06 ,  C12M21/12 ,  C12N1/18 ,  C12N9/2414 ,  C12Y302/01001 ,  C12Y302/01003 ,  Y02E50/10

摘要： Systems and methods that include starch derived from grain as a carbon source for propagation of microorganisms.

公开(公告)号：US20240110204A1

公开(公告)日：2024-04-04

申请号：US18484322

申请日：2023-10-10

申请人： Novozymes A/S

发明人： Chee-Leong Soong ,  James Ron Huffman ,  Monica Tassone ,  Jung Yi ,  Hanlin Ouyang

IPC分类号： C12P7/06 ,  C12N9/16 ,  C12N9/18 ,  C12N9/34

CPC分类号： C12P7/06 ,  C12N9/16 ,  C12N9/18 ,  C12N9/2428 ,  C12Y301/01004 ,  C12Y301/04003 ,  C12Y302/01001 ,  C12Y302/01003

摘要： Described herein are recombinant fermenting organisms having a heterologous polynucleotide encoding a phospholipase. Also described are processes for producing a fermentation product, such as ethanol, from starch or cellulosic-containing material with the recombinant fermenting organisms.

公开(公告)号：US20230226122A1

公开(公告)日：2023-07-20

申请号：US17879559

申请日：2022-08-02

申请人： Synlogic Operating Company, Inc.

发明人： Dean Falb ,  Jonathan W. Kotula ,  Vincent M. Isabella ,  Paul F. Miller ,  Suman Machinani ,  Saurabh Saha ,  Adam B. Fisher ,  Yves Millet ,  Ning Li ,  Jose M. Lora

IPC分类号： A61K35/74 ,  C07K14/52 ,  C07K14/525 ,  C07K14/53 ,  C07K14/54 ,  C07K14/57 ,  C07K14/705 ,  C07K16/28 ,  C12N9/26 ,  C12N15/62 ,  C12N15/74

CPC分类号： A61K35/74 ,  C07K14/53 ,  C07K14/57 ,  C07K14/521 ,  C07K14/525 ,  C07K14/5434 ,  C07K14/5443 ,  C07K14/70575 ,  C07K14/70596 ,  C07K16/2818 ,  C12N9/2408 ,  C12N15/62 ,  C12N15/74 ,  A61K33/243 ,  C07K2317/622 ,  C07K2319/21 ,  C12N2840/002 ,  C12Y302/01003 ,  C12Y302/01035

摘要： Genetically programmed microorganisms, such as bacteria or virus, pharmaceutical compositions thereof, and methods of modulating and treating cancers are disclosed.

公开(公告)号：US20230212634A1

公开(公告)日：2023-07-06

申请号：US17791940

申请日：2021-01-14

申请人： The Protein Brewery B.V.

发明人： Joyce Josephine Elisabeth Arnouts ,  María Vázquez Vitali ,  Lucie Parenicová ,  Niels Lauret ,  Maloe Kleine Haar ,  Jos Reijngoud ,  Stefan Robert Marsden ,  Wilhelmus Theodorus Antonius Maria De Laat

IPC分类号： C12P21/02 ,  C12N9/34

CPC分类号： C12P21/02 ,  C12N9/2428 ,  C12Y302/01003

摘要： The present invention relates to the animal-free production of animal-derived proteins for human consumption by expression of such proteins, e.g. ovalbumin, in fungal cells. The invention relates to fungal cells modified for the production of animal-derived proteins, such as ovalbumin and to methods wherein these cells are used for the production of animal-derived proteins.

公开(公告)号：US11690392B2

公开(公告)日：2023-07-04

申请号：US17048055

申请日：2019-04-17

申请人： Baylor College of Medicine

发明人： Antone Robert Opekun, Jr.

IPC分类号： A23L29/00 ,  A23L33/00 ,  A61K38/47

CPC分类号： A23L29/06 ,  A23L33/30 ,  A61K38/47 ,  C12Y302/01003

摘要： Embodiments of the disclosure include particular amyloglucosidase (AMG) compositions formulated as a nutriceutical or medicinal food, for example. The AMG compositions are formulated at a specific dosage and/or are lacking in one or more toxins or have substantially reduced levels of toxin, such as deoxynivalenol (vomit toxin). The AMG compositions are provided to individuals in need thereof, such as an individual with or at risk for congenital sucrase isomaltase syndrome, functional bowel disorders, small bowel bacterial overgrowth, protein-calorie malnutrition (marasmus), radiochemotherapy-induced mucositis and/or short-gut syndrome.

公开(公告)号：US11680255B2

公开(公告)日：2023-06-20

申请号：US17283565

申请日：2019-09-30

申请人： FEED RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCES

发明人： Huiying Luo ,  Bin Yao ,  Yujie Guo ,  Tao Tu ,  Yuan Wang ,  Huoqing Huang ,  Yingguo Bai ,  Xiaoyun Su ,  Yaru Wang ,  Kun Meng

IPC分类号： C12N9/34

CPC分类号： C12N9/2428 ,  C12Y302/01003

摘要： The present invention relates to the field of genetic engineering, particularly to a glucoamylase TIGa15, gene and application thereof. Said glucoamylase comprises the amino acid sequence of SEQ ID NO:1 or SEQ ID NO:2 and has the excellent enzymic properties, which can be applied to feed, food, and medicine industries, can be industrially produce with the genetic engineering technics.

公开(公告)号：US20190203189A1

公开(公告)日：2019-07-04

申请号：US16314250

申请日：2017-06-30

申请人： CJ CHEILJEDANG CORPORATION

发明人： Sungjae YANG ,  Hyun Kug CHO ,  Young Mi LEE ,  Seong Bo KIM ,  Seong Jun CHO

IPC分类号： C12N9/12 ,  C12N9/26 ,  C12N9/44 ,  C12N9/10 ,  C12N15/52

CPC分类号： C12N9/1205 ,  C12N9/1051 ,  C12N9/12 ,  C12N9/2414 ,  C12N9/2457 ,  C12N9/246 ,  C12N15/52 ,  C12P19/02 ,  C12Y204/01007 ,  C12Y207/01002 ,  C12Y207/01144 ,  C12Y302/01001 ,  C12Y302/01003 ,  C12Y302/0101 ,  C12Y302/01041 ,  C12Y302/01068

摘要： The present disclosure relates to tagatose-6-phosphate phosphatase consisting of an amino acid sequence of SEQ ID NO: 1, a nucleic acid encoding the tagatose-6-phosphate phosphatase, and a transformant comprising the nucleic acid. Additionally, the present disclosure relates to a composition for producing tagatose, which comprises the tagatose-6-phosphate phosphatase of the present disclosure, and a method for producing tagatose using the tagatose-6-phosphate phosphatase of the present disclosure.

公开(公告)号：US20180371439A1

公开(公告)日：2018-12-27

申请号：US16062519

申请日：2016-12-16

申请人： NOVOZYMES A/S

发明人： Joseph Jump ,  Nathaniel Edward Kreel ,  Bernardo Vidal, Jr. ,  Chee-Leong Soong ,  Madison Roberts ,  Melissa Carrie Hooss ,  Xinyu Shen

IPC分类号： C12N9/20 ,  C12N9/26 ,  C12N9/34 ,  C12N9/50 ,  C12P19/14 ,  C12P7/06

CPC分类号： C12N9/16 ,  C12N9/20 ,  C12N9/2414 ,  C12N9/2417 ,  C12N9/2428 ,  C12N9/2437 ,  C12N9/2457 ,  C12N9/50 ,  C12P7/06 ,  C12P19/14 ,  C12Y301/03008 ,  C12Y301/04 ,  C12Y301/04011 ,  C12Y302/01001 ,  C12Y302/01003 ,  C12Y302/01004 ,  C12Y302/01008 ,  C12Y302/01041 ,  C12Y304/21062 ,  C12Y304/23023 ,  C12Y304/24039 ,  Y02E50/17

摘要： A process of recovering oil, comprising (a) converting a starch-containing material into dextrins with an alpha-amylase; (b) saccharifying the dextrins using a carbohydrate source generating enzyme to form a sugar; (c) fermenting the sugar in a fermentation medium into a fermentation product using a fermenting organism; (d) recovering the fermentation product to form a whole stillage; (e) separating the whole stillage into thin stillage and wet cake; (e′) optionally concentrating the thin stillage into syrup; (f) recovering oil from the thin stillage and/or optionally the syrup, wherein a protease and a phospholipase are present and/or added during steps (a) to (c). Use of a protease and a phospholipase for increasing oil recovery yields from thin stillage and/or syrup in a fermentation product production process.