专利检索 ap:("DAVID J. LIM" OR "HAA-YUNG LEE" OR "PAUL WEBSTER" OR "ALI ANDALIBI" OR "JIAN-DONG LI" OR "TOMAS GANZ" OR "KIWEON CHA") AND inv:"TOMAS GANZ" 第 1 页

1.

发明申请
USE OF ANITMICROBIAL PROTEINS AND PEPTIDES FOR THE TREATMENT OF OTITIS MEDIA AND PARANASAL SINUSITIS 失效
标题翻译：用于治疗传播媒介和旁观者的抗微生物蛋白质和肽的用途

公开(公告)号：US20100204447A1

公开(公告)日：2010-08-12

申请号：US12764852

申请日：2010-04-21

申请人： DAVID J. LIM , HAA-YUNG LEE , PAUL WEBSTER , ALI ANDALIBI , JIAN-DONG LI , TOMAS GANZ , KIWEON CHA

发明人： DAVID J. LIM , HAA-YUNG LEE , PAUL WEBSTER , ALI ANDALIBI , JIAN-DONG LI , TOMAS GANZ , KIWEON CHA

IPC分类号： C07K14/435

CPC分类号： A61K38/1729 , A61K38/40 , A61K38/47 , C12Y302/01017

摘要： The pharmaceutical composition and a method of treatment of infectious diseases, such as otitis media, paranasal sinusitis, labyrinthitis and meningitis are described. The composition comprises EP2E or homologues thereof.

摘要翻译： 描述了药物组合物和治疗感染性疾病如中耳炎，鼻旁窦炎，迷路炎和脑膜炎的方法。组合物包含EP2E或其同系物。

2.

发明申请
Competitive Regulation of Hepcidin mRNA by Soluble and Cell-Associated Hemojuvelin 审中-公开
标题翻译：通过可溶性和细胞相关血红素的竞争性调节Hepcidin mRNA

公开(公告)号：US20100292171A1

公开(公告)日：2010-11-18

申请号：US12775032

申请日：2010-05-06

申请人： TOMAS GANZ , LAN LIN , YIGAL P. GOLDBERG

发明人： TOMAS GANZ , LAN LIN , YIGAL P. GOLDBERG

IPC分类号： A61K38/17 , C07K14/435 , G01N33/68 , C12N15/63 , C12N5/07 , A61P3/00 , A61P3/02

CPC分类号： A61K38/1709

摘要： Disclosed herein are hemojuvelin-specific siRNAs that vary hemojuvelin mRNA concentration. Also disclosed herein, GPI-hemojuvelin positively regulated hepcidin mRNA expression, independently of the IL-6 pathway, whereas soluble hemojuvelin (s-hemojuvelin) suppressed hepcidin mRNA expression in primary human hepatocytes in a log-linear dosedependent manner. Disclosed are compositions and methods for modulating diseases of iron metabolism and hepcidin expression or hepcidin levels.

摘要翻译： 本文公开了改变hemojuvelin mRNA浓度的hemojuvelin特异性siRNA。本文还公开了GPI-hemojuvelin与IL-6途径无关地正调节hepcidin mRNA表达，而可溶性hemojuvelin（s-hemojuvelin）以对数线性依赖方式抑制原代人肝细胞中的铁调素mRNA表达。公开了用于调节铁代谢和铁调素表达或铁调素水平的疾病的组合物和方法。