公开(公告)号：US20220378668A1

公开(公告)日：2022-12-01

申请号：US17771846

申请日：2020-10-30

Applicant: DENTSPLY SIRONA Inc.

Inventor： Amit JHA ,  Thomas SIMONTON

IPC: A61K6/20 ,  A61K6/891 ,  A61K6/61

Abstract: Described herein are dental treatment compositions, more particularly, a dental varnish composition useful in effective fluoridation, enhancement of remineralization the tooth enamel, and hypersensitivity through occlusion of dentine tubule. The dental varnish composition includes a hydrogel system and at least one fluoride source, wherein the dental varnish is water soluble. The hydrogel system includes at least one polyphenol having at least one phenol group, at least one polymer, and a metal ion. Described herein are also methods of making dental varnish composition in a single step and one pot synthesis.

公开(公告)号：US20190021966A1

公开(公告)日：2019-01-24

申请号：US16039963

申请日：2018-07-19

Applicant: DENTSPLY SIRONA INC.

Inventor： Amit JHA ,  Thomas C. SIMONTON

IPC: A61K8/41 ,  A61K8/69 ,  A61K8/21 ,  A61K8/73 ,  A61K8/81 ,  A61K8/04 ,  A61K8/58 ,  A61K8/49 ,  A61K8/23 ,  A61Q11/00

Abstract: Described herein are dental compositions, more particularly water soluble dental varnish composition useful for effective fluoridation, in situ biomimetic remineralization and improved adhesion to enamel. The dental composition includes a hydrogel-forming polymer having cohesive properties to itself and adhesive properties to a dental enamel. The hydrogel forming polymer includes a water-soluble polymer and an adhesion promotor chemically and/or physically conjugated to the water-soluble polymer. The embodiments also provide methods of forming a hydrogel forming polymer and use of hydrogel forming polymer to prepare such dental composition.

公开(公告)号：US20190021957A1

公开(公告)日：2019-01-24

申请号：US16039861

申请日：2018-07-19

Applicant: DENTSPLY SIRONA INC.

Inventor： Amit JHA ,  Thomas C. SIMONTON

IPC: A61K6/00 ,  C08L33/02 ,  C08L5/08

Abstract: Described herein are dental compositions, more particularly water soluble dental varnish composition useful for effective fluoridation, in situ biomimetic remineralization and improved adhesion to enamel. The dental composition includes a hydrogel-forming polymer having cohesive properties to itself and adhesive properties to a dental enamel. The hydrogel forming polymer includes a water-soluble polymer and an adhesion promotor chemically and/or physically conjugated to the water-soluble polymer. The embodiments also provide methods of forming a hydrogel forming polymer and use of hydrogel forming polymer to prepare such dental composition.

公开(公告)号：US20180296444A1

公开(公告)日：2018-10-18

申请号：US15939507

申请日：2018-03-29

Applicant: DENTSPLY SIRONA Inc.

Inventor： Amit JHA ,  Thomas C. SIMONTON

IPC: A61K6/00 ,  A61K8/21 ,  A61Q11/00 ,  A61K8/04 ,  A61K6/087 ,  A61K6/04 ,  A61K6/027

Abstract: Described herein are dental treatment compositions, more particularly, a dental varnish composition useful in effective fluoridation, enhancement of remineralization the tooth enamel, and hypersensitivity through occlusion of dentine tubule. The dental varnish composition includes a hydrogel system and at least one fluoride source, wherein the dental varnish is water soluble. The hydrogel system includes at least one polyphenol having at least one phenol group, at least one polymer, and a metal ion. Described herein are also methods of making such dental varnish composition.