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公开(公告)号：US20210386866A1
公开(公告)日：2021-12-16
申请号：US17339747
申请日：2021-06-04
Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
Inventor： SHIH-HSIEN CHUANG , WEI-TING SUN , YING-SHUAN LAILEE , CHUN-LIANG LAI , WUN-HUEI LIN , WIN-YIN WEI , SHIH-CHONG TSAI , CHENG-CHOU YU , CHAO-YANG HUANG
IPC: A61K47/68 , A61K38/07 , A61K31/407 , A61K31/198 , A61K31/4745 , A61K47/54 , A61P35/00
Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.
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公开(公告)号：US20190322762A1
公开(公告)日：2019-10-24
申请号：US15924878
申请日：2018-03-19
Inventor： SHIH-CHONG TSAI , TA-TUNG YUAN , SHIH-CHI TSENG , JIANN-SHIUN LAI , CHIA-CHENG WU , PO-YIN LIN , YA-WEI TSAI , CHAO-YANG HUANG , YING-YUNG LOK , CHUNG-HSIUN WU , HSIEN-YU TSAI , NENG-YAO SHIH , KO-JIUNN LIU , LI-TZONG CHEN
IPC: C07K16/40 , A61P35/00 , G01N33/574
Abstract: An antibody, or an antigen-binding fragment there, binding human ENO1 (GenBank: AAH506421.1) is provided. Methods for treating an ENO1 protein-related disease or disorder, inhibiting cancer invasion and diagnosis of cancer are also provided.
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公开(公告)号：US20200087697A1
公开(公告)日：2020-03-19
申请号：US16470807
申请日：2017-12-29
Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
Inventor： SHIH-CHONG TSAI , CHUN-CHUNG LEE , MENG-SHENG LEE , CHING-YAO CHEN , SHIH-HSIEN CHUANG , YI-JEN CHEN , WIN-YIN WEI
Abstract: A process for modifying glycoproteins is provided. The invention also provides a process for producing glycoprotein payload conjugates, as well as the conjugates produced thereby.
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