公开(公告)号：US20210386866A1

公开(公告)日：2021-12-16

申请号：US17339747

申请日：2021-06-04

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： SHIH-HSIEN CHUANG ,  WEI-TING SUN ,  YING-SHUAN LAILEE ,  CHUN-LIANG LAI ,  WUN-HUEI LIN ,  WIN-YIN WEI ,  SHIH-CHONG TSAI ,  CHENG-CHOU YU ,  CHAO-YANG HUANG

IPC: A61K47/68 ,  A61K38/07 ,  A61K31/407 ,  A61K31/198 ,  A61K31/4745 ,  A61K47/54 ,  A61P35/00

Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.