公开(公告)号：US20240420939A1

公开(公告)日：2024-12-19

申请号：US18704242

申请日：2022-10-26

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Aaron Stella ,  Michal Weinstock ,  Yongquan Lai ,  Subhasish Purkayastha ,  Scott Daniels

IPC: H01J49/04 ,  H01J49/00

Abstract: The presently claimed and described technology provides a sample processing system comprising at least one sample introduction device, wherein the at least one sample introduction device is configured to receive a sample; a mass analyzer coupled to the sample introduction device; a control system configured to at least control the at least one sample introduction device and/or the mass analyzer, wherein the mass analyzer is configured to perform a first mass analysis on the sample, wherein the first mass analysis is mass screening for an analyte of interest in the sample, and wherein if the analyte of interest is detected in the sample, the mass analyzer is configured to perform a second mass analysis, wherein the second mass analysis is a quantitative analysis, comprising: ionizing the sample; monitoring, by mass spectrometry, at least one product ion transition for the at least one analyte and at least one isotopic ion transition for the at least one analyte; determining intensity and/or abundance of the at least one product ion transition and/or the at least one isotopic ion transition; and quantifying the at least one analyte present in the sample using the intensity and/or abundance of the at least one product ion transition and/or isotopic ion transition.