公开(公告)号：US20240282560A1

公开(公告)日：2024-08-22

申请号：US18571542

申请日：2022-06-24

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Lyle L. BURTON ,  Nic BLOOMFIELD ,  David Michael COX

IPC: H01J49/00 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/0031 ,  H01J49/0036 ,  H01J49/40 ,  H01J49/4215

Abstract: The technology relates to systems and methods for performing mass spectrometry analysis of a sample. An example method may include receiving, as input via an input device, a target mass-to-charge (m/z) ratio for a fragment ion of interest; setting a target m/z range based on the target m/z ratio; ionizing the sample to generate precursor ions; fragmenting the precursor ions to generate fragment ions having a range of mass-to-charge ratios larger than the target m/z range; accelerating the fragment ions to a detector such that fragment ions inside and outside of the target m/z ratio are detected; summing a count of fragment ions within the target m/z range without storing ion counts for fragment ions outside of the target m/z range; and storing the summed ion count as corresponding with the target mass-to-charge ratio.

公开(公告)号：US20240230605A1

公开(公告)日：2024-07-11

申请号：US18558592

申请日：2022-05-04

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Lyle L. BURTON ,  Stephen TATE

IPC: G01N30/86

CPC classification number: G01N30/8634 ,  G01N30/8606 ,  G01N30/8693

Abstract: Methods and systems for improving peak integration in mass spectrometry. A method may include accessing an ion data series; generating a set of prospective peak integrations for a target peak in the ion data series; providing, as input to a trained machine learning model, at least one peak characteristic for each prospective peak integration in the set of prospective peak integrations; processing the provided input, by the trained machine learning model, to generate an output from the trained machine learning model; based on the output, generating a ranking of one or more of the prospective peak integrations; and based on one of the prospective peak integrations, generating an ion amount represented by the target peak.