公开(公告)号：US20240347331A1

公开(公告)日：2024-10-17

申请号：US18682218

申请日：2022-08-10

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Gordana IVOSEV ,  Nic BLOOMFIELD

IPC: H01J49/00

CPC classification number: H01J49/0045

Abstract: Methods for correlating a product ion in a mass spectrum to a precursor ion are disclosed herein, comprising determining a precursor ion ml z corresponding to the product ion as an m/z at which the product ion appears in a maximum amount of the series of mass spectra. Methods also can comprise obtaining a series of mass spectra for a sample across a mass range, each of the series of mass spectra having a precursor ion transmission window defined by a width (W) that overlaps with that of at least two of the series of mass spectra by a step size (S).

公开(公告)号：US20240282560A1

公开(公告)日：2024-08-22

申请号：US18571542

申请日：2022-06-24

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Lyle L. BURTON ,  Nic BLOOMFIELD ,  David Michael COX

IPC: H01J49/00 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/0031 ,  H01J49/0036 ,  H01J49/40 ,  H01J49/4215

Abstract: The technology relates to systems and methods for performing mass spectrometry analysis of a sample. An example method may include receiving, as input via an input device, a target mass-to-charge (m/z) ratio for a fragment ion of interest; setting a target m/z range based on the target m/z ratio; ionizing the sample to generate precursor ions; fragmenting the precursor ions to generate fragment ions having a range of mass-to-charge ratios larger than the target m/z range; accelerating the fragment ions to a detector such that fragment ions inside and outside of the target m/z ratio are detected; summing a count of fragment ions within the target m/z range without storing ion counts for fragment ions outside of the target m/z range; and storing the summed ion count as corresponding with the target mass-to-charge ratio.

公开(公告)号：US20230282469A1

公开(公告)日：2023-09-07

申请号：US18040774

申请日：2021-08-06

Applicant: Nic BLOOMFIELD ,  Gordana IVOSEV ,  Pavel RYUMIN ,  DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Nic BLOOMFIELD ,  Gordana IVOSEV ,  Pavel RYUMIN

IPC: H01J49/00

CPC classification number: H01J49/0036

Abstract: A method for assigning charge state in mass spectrometry includes receiving a detector response signal corresponding to a plurality of ion arrival events. The detector response signal includes information related to individual ion responses generated by a detector for each ion arrival event. Detector response profiles are generated for mass-to-charge (m/z) bins of a mass spectrum generated from the ion arrival events based on the detector response signal. The m/z bins are grouped into a plurality of groups based on a similarity of the detector response profiles of the m/z bins. A charge state is assigned to one or more features based on the groups of m/z bins.

公开(公告)号：US20230298876A1

公开(公告)日：2023-09-21

申请号：US18040779

申请日：2021-08-06

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Nic BLOOMFIELD ,  Gordana IVOSEV ,  Pavel RYUMIN

IPC: H01J49/00 ,  H01J49/02

CPC classification number: H01J49/0036 ,  H01J49/025

Abstract: Devices and methods are described for assigning charge state to detected ions from a mass analysis instrument. In one of the methods, the charge state may be assigned, for instance, by evaluation a detector response signal including information related to individual ion responses generated by an ion detector for each ion arrival event captured by the detector. The detector response signal may then be evaluated in combination with one or more additional features corresponding to the ion arrival event to assign a charge state for that ion arrival event.

公开(公告)号：US20210366701A1

公开(公告)日：2021-11-25

申请号：US16980956

申请日：2019-04-10

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Nic BLOOMFIELD ,  Igor CHERNUSHEVICH ,  Robert HAUFLER

IPC: H01J49/40 ,  H01J49/00 ,  H01J49/06 ,  H01J49/42

Abstract: Systems and methods are disclosed for dynamically switching an ion guide and a TOF mass analyzer between concentrating or not concentrating ions in a targeted acquisition. Product ions are ejected from the ion guide into the TOF mass analyzer and the intensity of a known product ion is measured at two or more time steps. The ion guide initially ejects product ions using a sequential or Zeno pulsing mode that concentrates product ions with different m/z values within the TOF mass analyzer at the same time. If the intensity of the product ion is increasing and greater than a threshold intensity, the ion guide switches to a continuous or normal pulsing mode that does not concentrate ions with different m/z values in the TOF mass analyzer at the same time. Similarly, if the intensity decreases below a threshold in continuous mode, the ion guide switches back to sequential mode.