公开(公告)号：US20250130199A1

公开(公告)日：2025-04-24

申请号：US18722014

申请日：2022-12-13

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Nicholas G. Bloomfield ,  Igor CHERNUSHEVICH ,  Yves LE BLANC

IPC: G01N27/623 ,  G01N27/624 ,  H01J49/06 ,  H01J49/24

Abstract: Methods and systems for performing differential mobility spectrometry-mass spectrometry (DMS-MIS) are provided herein. In various aspects, methods and systems described may be effective to improve the performance of a differential mobility spectrometry device and a MS device operating in tandem relative to conventional systems for DMS-MS. In certain aspects, methods and systems in accordance with the present teachings utilize an ion guide which comprises a multipole rod set and a plurality of auxiliary electrodes to which a DC voltage is applied during transmission of ions through the ion guide so as to generate an axial electric field along a longitudinal axis of the ion guide to accelerate the ions toward the outlet end of the ion guide. This may significantly reduce a pause duration between the application of different compensation voltage values without substantially increasing the likelihood of contamination or cross-talk between groups of ions transmitted by the differential mobility spectrometry device at each compensation voltage value.

公开(公告)号：US12283474B2

公开(公告)日：2025-04-22

申请号：US16980956

申请日：2019-04-10

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Nicholas G. Bloomfield ,  Igor Chernushevich ,  Robert Haufler

IPC: H01J49/40 ,  H01J49/00 ,  H01J49/06 ,  H01J49/42

Abstract: Systems and methods are disclosed for dynamically switching an ion guide and a TOF mass analyzer between concentrating or not concentrating ions in a targeted acquisition. Product ions are ejected from the ion guide into the TOF mass analyzer and the intensity of a known product ion is measured at two or more time steps. The ion guide initially ejects product ions using a sequential or Zeno pulsing mode that concentrates product ions with different m/z values within the TOF mass analyzer at the same time. If the intensity of the product ion is increasing and greater than a threshold intensity, the ion guide switches to a continuous or normal pulsing mode that does not concentrate ions with different m/z values in the TOF mass analyzer at the same time. Similarly, if the intensity decreases below a threshold in continuous mode, the ion guide switches back to sequential mode.