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1.发明申请公开(公告)号：US20220181132A1
公开(公告)日：2022-06-09
申请号：US17457055
申请日：2021-12-01
发明人： Ronald F. Bonner , Stephen A. Tate , Rudolf Aebersold , Pedro Jose Navarro Alvarez , Oliver Rinner , Lukas Reiter , Ludovic Gillet
摘要： Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.
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2.发明申请公开(公告)号：US20190311892A1
公开(公告)日：2019-10-10
申请号：US16450594
申请日：2019-06-24
发明人： Ronald F. Bonner , Stephen A. Tate , Rudolf Aebersold , Pedro Jose Navarro Alvarez , Oliver Rinner , Lukas Reiter , Ludovic Gillet
摘要： Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.
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3.发明申请Data Independent Acquisition of Product Ion Spectra and Reference Spectra Library Matching 审中-公开数据独立采集产品离子谱和参考光谱库匹配公开(公告)号：US20160225594A1
公开(公告)日：2016-08-04
申请号：US15098196
申请日：2016-04-13
发明人： Ronald F. Bonner , Stephen A. Tate , Rudolf Aebersold , Pedro Jose Navarro Alvarez , Oliver Rinner , Lukas Reiter , Ludovic Gillet
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , G01N30/7233 , G16C20/20 , G16C20/90 , H01J49/0031 , H01J49/004 , H01J49/0045 , H01J49/42
摘要： Systems and methods are disclosed for detecting compounds in a sample using a tandem mass spectrometer. A sample comprising a plurality of detectable compounds that have been separated in time over a time interval is introduced into a tandem mass spectrometer. A sample product ion spectra is obtained. The presence of one or more known compounds of interest in the sample product ion spectra is determined. A compound is identified as present in the sample if the score associated with said compound meets a threshold value set as indicative of the likely presence of the compound in the sample.
摘要翻译： 公开了使用串联质谱仪检测样品中的化合物的系统和方法。 将包含多个可在时间上分离的可检测化合物的样品引入串联质谱仪。 得到样品产物离子光谱。 确定样品产物离子光谱中一种或多种已知化合物的存在。 如果与所述化合物相关的分数满足设定为指示样品中化合物可能存在的阈值，则鉴定化合物存在于样品中。
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公开(公告)号：US09343282B2
公开(公告)日：2016-05-17
申请号：US14922823
申请日：2015-10-26
发明人： Stephen A. Tate , Ronald F. Bonner
CPC分类号： H01J49/0045 , G01N30/7233 , G01N30/8631 , G06F19/703 , H01J49/0009 , H01J49/0031 , H01J49/0036 , H01J49/004
摘要： Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor. The two or more target widths can have the same width or variable widths. A tandem mass spectrometer is instructed to perform two or more fragmentation scans across the mass range using the processor. Each fragmentation scan of the two or more fragmentation scans includes a measured mass selection window width. The two or more measured widths of the two or more fragmentation scans can have the same width or variable widths. At least two of the two or more measured mass selection window widths overlap. The overlap in measured mass selection window widths corresponds to at least one target mass selection window width.
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公开(公告)号：US20160079048A1
公开(公告)日：2016-03-17
申请号：US14944467
申请日：2015-11-18
发明人： Ronald F. Bonner , Stephen A. Tate
IPC分类号： H01J49/00
CPC分类号： H01J49/0045 , H01J49/0027 , H01J49/0031 , H01J49/04
摘要： Systems and methods are used to rapidly screening samples. A fast sample introduction device that is non-chromatographic is instructed to supply each sample of a plurality samples to a tandem mass spectrometer using a processor. The fast sample introduction device can include a flow injection analysis device, an ion mobility analysis device, or a rapid sample cleanup device. The tandem mass spectrometer is instructed to perform fragmentation scans at two or more mass selection windows across a mass range of each sample of the plurality of samples using the processor. The two or more mass selection windows across the mass range can have fixed or variable window widths. The tandem mass spectrometer can be instructed to obtain a mass spectrum of the mass range before instructing the tandem mass spectrometer to perform the fragmentation scans.
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6.发明授权Systems and methods for using interleaving window widths in tandem mass spectrometry 有权在串联质谱中使用交织窗口宽度的系统和方法公开(公告)号：US09202677B2
公开(公告)日：2015-12-01
申请号：US14401032
申请日：2013-04-19
发明人： Stephen A. Tate , Ronald F. Bonner
CPC分类号： H01J49/0045 , G01N30/7233 , G01N30/8631 , G06F19/703 , H01J49/0009 , H01J49/0031 , H01J49/0036 , H01J49/004
摘要： Systems and methods are provided for analyzing a sample using overlapping measured mass selection window widths. A mass range of a sample is divided into two or more target mass selection window widths using a processor. The two or more target widths can have the same width or variable widths. A tandem mass spectrometer is instructed to perform two or more fragmentation scans across the mass range using the processor. Each fragmentation scan of the two or more fragmentation scans includes a measured mass selection window width. The two or more measured widths of the two or more fragmentation scans can have the same width or variable widths. At least two of the two or more measured mass selection window widths overlap. The overlap in measured mass selection window widths corresponds to at least one target mass selection window width.
摘要翻译： 提供了系统和方法，用于使用重叠的测量质量选择窗口宽度来分析样本。 使用处理器将样本的质量范围分为两个或更多个目标质量选择窗口宽度。 两个或多个目标宽度可以具有相同的宽度或可变宽度。 指示串联质谱仪使用处理器在质量范围内执行两次或更多次碎片扫描。 两个或多个碎片扫描的每个碎片扫描包括测量的质量选择窗口宽度。 两个或更多个碎片扫描的两个或多个测量宽度可以具有相同的宽度或可变宽度。 两个或更多个测量质量选择窗口宽度中的至少两个重叠。 测量的质量选择窗口宽度中的重叠对应于至少一个目标质量选择窗口宽度。
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7.发明申请Systems and Methods for Utilizing Accurate Mass Information for Elemental Composition Determination 审中-公开用于元素组成确定的精确质量信息的系统和方法公开(公告)号：US20150228464A1
公开(公告)日：2015-08-13
申请号：US14617805
申请日：2015-02-09
发明人： Eva Duchoslav , Ronald F. Bonner , Lyle Burton
IPC分类号： H01J49/00
CPC分类号： H01J49/004 , H01J49/0036
摘要： A precursor ion spectrum and one or more product ion spectra are received from a tandem mass spectrometer that analyzes a compound. For a selected precursor ion peak in the precursor ion spectrum, mass differences are calculated between other peaks and one or more limitations on the number of elements in the selected precursor ion are generated. For a precursor ion peak, a product ion spectrum is located from the one or more product ion spectra. For a selected product ion peak in the product ion spectrum, mass differences between other peaks are calculated and one or more limitations on the number of elements in the selected product ion are generated. Limitations on the number of elements from the precursor ion and the product ions are combined. One or more elemental compositions are generated from a mass of the selected precursor ion peak and the combined limitations.
摘要翻译： 从分析化合物的串联质谱仪接收前体离子谱和一个或多个产物离子光谱。 对于前体离子谱中所选择的前体离子峰，在其它峰之间计算质量差异，并且对所选择的前体离子中的元素数量产生一个或多个限制。 对于前体离子峰，产物离子光谱位于一个或多个产物离子光谱上。 对于产物离子谱中的选定产物离子峰，计算其它峰之间的质量差，并且产生对所选产物离子中元素数量的一个或多个限制。 来自前体离子和产物离子的元素数目的限制被组合。 从所选择的前体离子峰的质量和组合的限制产生一种或多种元素组合物。
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8.发明申请Systems and Methods for Using Variable Mass Selection Window Widths in Tandem Mass Spectrometry 有权在串联质谱中使用可变质量选择窗口宽度的系统和方法公开(公告)号：US20150129757A1
公开(公告)日：2015-05-14
申请号：US14328550
申请日：2014-07-10
发明人： Ronald F. Bonner , Stephen A. Tate
IPC分类号： H01J49/00
CPC分类号： H01J49/0081 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0045
摘要： Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable mass selection window widths. The selection of the different mass selection window widths can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two fragmentation scans of the sample.
摘要翻译： 系统和方法用于使用可变质量选择窗口宽度来分析样本。 指示串联质谱仪使用处理器对具有不同质量选择窗口宽度的样品进行至少两次碎片扫描。 串联质谱仪包括质量分析器，允许质量选择窗口宽度可变。 不同质量选择窗口宽度的选择可以基于样品化合物的一种或多种性质。 性质可以包括根据预期化合物的分子量分布计算的样品化合物分子量分布，或由一种或多种已知化合物的分子量列表确定。 也可以指示串联质谱仪在指示串联质谱仪进行样品的至少两次碎片扫描之前对样品进行分析。
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公开(公告)号：US20220262610A1
公开(公告)日：2022-08-18
申请号：US17597763
申请日：2020-07-22
IPC分类号： H01J49/00
摘要： Apparatus is provided and an IDA method is modified to detect and separately dissociate alkali-metal adducts of a compound. An ion source device ionizes one or more compounds of a sample, producing an ion beam. A mass filter selects a mass range of precursor ions from the ion beam, a mass analyzer measures intensities and m/z values of the precursor ions, and one or more of the precursor ions are selected for a peak list. For each pair of precursor ions of the peak list, if an m/z difference between the pair corresponds to an m/z difference between an alkali metal ion and another alkali metal ion or a proton, an ExD device is used to dissociate one precursor ion or both precursor ions of the pair using the processor. A CID device is used to dissociate all other precursor ions of the peak list.
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10.发明授权公开(公告)号：US11107666B2
公开(公告)日：2021-08-31
申请号：US17087051
申请日：2020-11-02
发明人： Ronald F. Bonner , Stephen A. Tate
IPC分类号： H01J49/00
摘要： Systems and methods are used to analyze a sample using variable mass selection window widths. A tandem mass spectrometer is instructed to perform at least two fragmentation scans of a sample with different mass selection window widths using a processor. The tandem mass spectrometer includes a mass analyzer that allows variable mass selection window widths. The selection of the different mass selection window widths can be based on one or more properties of sample compounds. The properties may include a sample compound molecular weight distribution that is calculated from a molecular weight distribution of expected compounds or is determined from a list of molecular weights for one or more known compounds. The tandem mass spectrometer can also be instructed to perform an analysis of the sample before instructing the tandem mass spectrometer to perform the at least two fragmentation scans of the sample.
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