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    14-3-3 ZETA OVER-EXPRESSION AS A POOR PROGNOSIS FACTOR, AND A THERAPEUTIC TARGET IN MULTIPLE CANCER TYPE
    1.
    发明申请
    14-3-3 ZETA OVER-EXPRESSION AS A POOR PROGNOSIS FACTOR, AND A THERAPEUTIC TARGET IN MULTIPLE CANCER TYPE 失效
    14-3-3 ZETA超表达作为不良预后因素，多种癌症类型的治疗目标

    公开(公告)号：US20080318231A1

    公开(公告)日：2008-12-25

    申请号：US11950264

    申请日：2007-12-04

    申请人： DIHUA YU ,  Jun Yao ,  Christopher L. Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael E. Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina T. Nguyen

    发明人： DIHUA YU ,  Jun Yao ,  Christopher L. Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael E. Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina T. Nguyen

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/574 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/178

    摘要： Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more candidate substances to determine their ability to modulate the expression and/or function of 14-3-3 zeta, selecting a candidate substance determined to modulate the expression and/or function of 14-3-3 zeta, and making a pharmaceutical composition that includes the selected candidate substance. In addition, methods of treating a subject with a hyperproliferative disease, including making a pharmaceutical agent by the methods set forth herein, and administering the pharmaceutical agent to a subject, are disclosed. The hyperproliferative disease can be cancer, such as breast cancer.

    摘要翻译： 公开了确定患有过度增生性疾病的受试者的预后的方法，包括确定受试者中14-3-3ζ的表达和/或功能。 还公开了制备调节凋亡的药剂的方法，包括获得一种或多种候选物的步骤，测试一种或多种候选物质以确定其调节14-3-3ζ的表达和/或功能的能力， 选择确定调节14-3-3ζ的表达和/或功能的候选物质，并制备包含所选候选物质的药物组合物。 此外，公开了通过本发明所述的方法制备药剂并且将药剂施用于受试者的治疗患有过度​​增殖性疾病的受试者的方法。 过度增生性疾病可以是癌症，例如乳腺癌。

    14-3-3 Zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer type
    2.
    发明授权
    14-3-3 Zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer type 失效
    14-3-3 Zeta过表达作为不良预后因素，是多种癌症类型的治疗靶点

    公开(公告)号：US07709205B2

    公开(公告)日：2010-05-04

    申请号：US11950264

    申请日：2007-12-04

    申请人： Dihua Yu ,  Jun Yao ,  Christopher L. Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael E. Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina T. Nguyen

    发明人： Dihua Yu ,  Jun Yao ,  Christopher L. Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael E. Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina T. Nguyen

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/574 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/178

    摘要： Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more candidate substances to determine their ability to modulate the expression and/or function of 14-3-3 zeta, selecting a candidate substance determined to modulate the expression and/or function of 14-3-3 zeta, and making a pharmaceutical composition that includes the selected candidate substance. In addition, methods of treating a subject with a hyperproliferative disease, including making a pharmaceutical agent by the methods set forth herein, and administering the pharmaceutical agent to a subject, are disclosed. The hyperproliferative disease can be cancer, such as breast cancer.

    摘要翻译： 公开了确定患有过度增生性疾病的受试者的预后的方法，包括确定受试者中14-3-3ζ的表达和/或功能。 还公开了制备调节凋亡的药剂的方法，包括获得一种或多种候选物的步骤，测试一种或多种候选物质以确定其调节14-3-3ζ的表达和/或功能的能力， 选择确定调节14-3-3ζ的表达和/或功能的候选物质，并制备包含所选候选物质的药物组合物。 此外，公开了通过本发明所述的方法制备药剂并且将药剂施用于受试者的治疗患有过度​​增殖性疾病的受试者的方法。 过度增生性疾病可以是癌症，例如乳腺癌。

    14-3-3 zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer types
    3.
    发明授权
    14-3-3 zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer types 有权
    14-3-3ζ过表达作为一种不良预后因子，是多种癌症类型的治疗靶点

    公开(公告)号：US07316907B2

    公开(公告)日：2008-01-08

    申请号：US10938387

    申请日：2004-09-10

    申请人： Dihua Yu ,  Jun Yao ,  Christopher L. Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael E. Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina T. Nguyen

    发明人： Dihua Yu ,  Jun Yao ,  Christopher L. Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael E. Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina T. Nguyen

    IPC分类号： G01N33/53 ,  G01N33/574

    CPC分类号： G01N33/574 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/178

    摘要： Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more candidate substances to determine their ability to modulate the expression and/or function of 14-3-3 zeta, selecting a candidate substance determined to modulate the expression and/or function of 14-3-3 zeta, and making a pharmaceutical composition that includes the selected candidate substance. In addition, methods of treating a subject with a hyperproliferative disease, including making a pharmaceutical agent by the methods set forth herein, and administering the pharmaceutical agent to a subject, are disclosed. The hyperproliferative disease can be cancer, such as breast cancer.

    摘要翻译： 公开了确定患有过度增生性疾病的受试者的预后的方法，包括确定受试者中14-3-3ζ的表达和/或功能。 还公开了制备调节凋亡的药剂的方法，包括获得一种或多种候选物的步骤，测试一种或多种候选物质以确定其调节14-3-3ζ的表达和/或功能的能力， 选择确定调节14-3-3ζ的表达和/或功能的候选物质，并制备包含所选候选物质的药物组合物。 此外，公开了通过本发明所述的方法制备药剂并且将药剂施用于受试者的治疗患有过度​​增殖性疾病的受试者的方法。 过度增生性疾病可以是癌症，例如乳腺癌。

    14-3-3 zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer types
    4.
    发明申请
    14-3-3 zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer types 有权
    14-3-3ζ过表达作为一种不良预后因子，是多种癌症类型的治疗靶点

    公开(公告)号：US20050148532A1

    公开(公告)日：2005-07-07

    申请号：US10938387

    申请日：2004-09-10

    申请人： Dihua Yu ,  Jun Yao ,  Christopher Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina Nguyen

    发明人： Dihua Yu ,  Jun Yao ,  Christopher Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina Nguyen

    IPC分类号： A61K20060101 ,  A61K48/00 ,  C12Q1/68 ,  G01N33/574

    CPC分类号： G01N33/574 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/178

    摘要： Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more candidate substances to determine their ability to modulate the expression and/or function of 14-3-3 zeta, selecting a candidate substance determined to modulate the expression and/or function of 14-3-3 zeta, and making a pharmaceutical composition that includes the selected candidate substance. In addition, methods of treating a subject with a hyperproliferative disease, including making a pharmaceutical agent by the methods set forth herein, and administering the pharmaceutical agent to a subject, are disclosed. The hyperproliferative disease can be cancer, such as breast cancer.

    摘要翻译： 公开了确定患有过度增生性疾病的受试者的预后的方法，包括确定受试者中14-3-3ζ的表达和/或功能。 还公开了制备调节凋亡的药剂的方法，包括获得一种或多种候选物的步骤，测试一种或多种候选物质以确定其调节14-3-3ζ的表达和/或功能的能力， 选择确定调节14-3-3ζ的表达和/或功能的候选物质，并制备包含所选候选物质的药物组合物。 此外，公开了通过本发明所述的方法制备药剂并且将药剂施用于受试者的治疗患有过度​​增殖性疾病的受试者的方法。 过度增生性疾病可以是癌症，例如乳腺癌。

    Speaker assembly
    5.
    发明授权
    Speaker assembly 失效
    扬声器组件

    公开(公告)号：US08369559B2

    公开(公告)日：2013-02-05

    申请号：US12826587

    申请日：2010-06-29

    申请人： Ying-Ye Liang ,  Shi-Jun Yang ,  Ping Li ,  Xiao-Yong Cui

    发明人： Ying-Ye Liang ,  Shi-Jun Yang ,  Ping Li ,  Xiao-Yong Cui

    IPC分类号： H04R1/02

    CPC分类号： H04R1/025

    摘要： A speaker assembly includes a base including two receiving holes, a cover mounted on a first surface the base, a speaker, a flexible printed circuit (FPC) attached to a second surface the base opposite to the first surface, and two springs received in the receiving holes. The cover includes a receiving space to receive the speaker. The speaker includes two first pads. The FPC includes two second pads. The springs electrically connect the first pads to the second pads.

    摘要翻译： 扬声器组件包括：底座，包括两个接收孔;安装在第一表面上的盖底座;扬声器;附接到与第一表面相对的基座的第二表面的柔性印刷电路板;以及两个弹簧， 接收孔 盖子包括接收扬声器的接收空间。 扬声器包括两个第一焊盘。 FPC包括两个第二垫。 弹簧将第一焊盘电连接到第二焊盘。

    DISH CONVEYING DEVICE USED IN CATERING STORE
    9.
    发明申请
    DISH CONVEYING DEVICE USED IN CATERING STORE 审中-公开
    在餐饮店使用的输送设备

    公开(公告)号：US20160286987A1

    公开(公告)日：2016-10-06

    申请号：US15103341

    申请日：2014-10-27

    申请人： Ping Li

    发明人： Ping Li

    IPC分类号： A47F10/06 ,  B65G47/36 ,  B65G35/06

    CPC分类号： A47F10/06 ,  B65G35/06 ,  B65G47/36

    摘要： It discloses a dish sending device for restaurant, comprising: a suspended guide rail, traveling trolley provided on the guide rail, lifting mechanism provided on the travelling trolley; a dish container connection device is provided at the lower end of the lifting mechanism; a trolley sliding contact line is provided on the guide rail, and the travelling trolley is provided with a carbon brush for contact with the trolley sliding contact line.

    摘要翻译： 它公开了一种用于餐厅的盘发送装置，包括：悬挂的导轨，设置在导轨上的行进小车，设置在行进手推车上的提升机构; 在提升机构的下端设有餐具容器连接装置; 在导轨上设置有台车滑动接触线，并且行进台车设置有用于与台车滑动接触线接触的碳刷。

    Electronic device
    10.
    发明授权
    Electronic device 有权
    电子设备

    公开(公告)号：US08811000B2

    公开(公告)日：2014-08-19

    申请号：US13535504

    申请日：2012-06-28

    申请人： Bao-Gang Zhao ,  Ping Li

    发明人： Bao-Gang Zhao ,  Ping Li

    IPC分类号： H05K5/02

    CPC分类号： H05K5/0013 ,  H05K5/0004

    摘要： An electronic device includes a bottom cover and a front panel. The bottom cover includes at least one first wall. The at least one first wall includes a locking portion set on an inner surface of the at least one first wall. The front panel defines at least one hole. The at least one hole is locked to the locking portion to secure the front panel to the bottom cover.

    摘要翻译： 电子设备包括底盖和前面板。 底盖包括至少一个第一壁。 所述至少一个第一壁包括设置在所述至少一个第一壁的内表面上的锁定部分。 前面板至少定义一个孔。 至少一个孔被锁定到锁定部分以将前面板固定到底盖。