公开(公告)号：US20080318231A1

公开(公告)日：2008-12-25

申请号：US11950264

申请日：2007-12-04

申请人： DIHUA YU ,  Jun Yao ,  Christopher L. Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael E. Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina T. Nguyen

发明人： DIHUA YU ,  Jun Yao ,  Christopher L. Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael E. Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina T. Nguyen

IPC分类号： C12Q1/68

CPC分类号： G01N33/574 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/178

摘要： Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more candidate substances to determine their ability to modulate the expression and/or function of 14-3-3 zeta, selecting a candidate substance determined to modulate the expression and/or function of 14-3-3 zeta, and making a pharmaceutical composition that includes the selected candidate substance. In addition, methods of treating a subject with a hyperproliferative disease, including making a pharmaceutical agent by the methods set forth herein, and administering the pharmaceutical agent to a subject, are disclosed. The hyperproliferative disease can be cancer, such as breast cancer.

摘要翻译： 公开了确定患有过度增生性疾病的受试者的预后的方法，包括确定受试者中14-3-3ζ的表达和/或功能。 还公开了制备调节凋亡的药剂的方法，包括获得一种或多种候选物的步骤，测试一种或多种候选物质以确定其调节14-3-3ζ的表达和/或功能的能力， 选择确定调节14-3-3ζ的表达和/或功能的候选物质，并制备包含所选候选物质的药物组合物。 此外，公开了通过本发明所述的方法制备药剂并且将药剂施用于受试者的治疗患有过度​​增殖性疾病的受试者的方法。 过度增生性疾病可以是癌症，例如乳腺癌。

公开(公告)号：US07709205B2

公开(公告)日：2010-05-04

申请号：US11950264

申请日：2007-12-04

申请人： Dihua Yu ,  Jun Yao ,  Christopher L. Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael E. Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina T. Nguyen

发明人： Dihua Yu ,  Jun Yao ,  Christopher L. Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael E. Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina T. Nguyen

IPC分类号： C12Q1/68

CPC分类号： G01N33/574 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/178

摘要： Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more candidate substances to determine their ability to modulate the expression and/or function of 14-3-3 zeta, selecting a candidate substance determined to modulate the expression and/or function of 14-3-3 zeta, and making a pharmaceutical composition that includes the selected candidate substance. In addition, methods of treating a subject with a hyperproliferative disease, including making a pharmaceutical agent by the methods set forth herein, and administering the pharmaceutical agent to a subject, are disclosed. The hyperproliferative disease can be cancer, such as breast cancer.

摘要翻译： 公开了确定患有过度增生性疾病的受试者的预后的方法，包括确定受试者中14-3-3ζ的表达和/或功能。 还公开了制备调节凋亡的药剂的方法，包括获得一种或多种候选物的步骤，测试一种或多种候选物质以确定其调节14-3-3ζ的表达和/或功能的能力， 选择确定调节14-3-3ζ的表达和/或功能的候选物质，并制备包含所选候选物质的药物组合物。 此外，公开了通过本发明所述的方法制备药剂并且将药剂施用于受试者的治疗患有过度​​增殖性疾病的受试者的方法。 过度增生性疾病可以是癌症，例如乳腺癌。

公开(公告)号：US07316907B2

公开(公告)日：2008-01-08

申请号：US10938387

申请日：2004-09-10

申请人： Dihua Yu ,  Jun Yao ,  Christopher L. Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael E. Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina T. Nguyen

发明人： Dihua Yu ,  Jun Yao ,  Christopher L. Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael E. Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina T. Nguyen

IPC分类号： G01N33/53 ,  G01N33/574

CPC分类号： G01N33/574 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/178

摘要： Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more candidate substances to determine their ability to modulate the expression and/or function of 14-3-3 zeta, selecting a candidate substance determined to modulate the expression and/or function of 14-3-3 zeta, and making a pharmaceutical composition that includes the selected candidate substance. In addition, methods of treating a subject with a hyperproliferative disease, including making a pharmaceutical agent by the methods set forth herein, and administering the pharmaceutical agent to a subject, are disclosed. The hyperproliferative disease can be cancer, such as breast cancer.

摘要翻译： 公开了确定患有过度增生性疾病的受试者的预后的方法，包括确定受试者中14-3-3ζ的表达和/或功能。 还公开了制备调节凋亡的药剂的方法，包括获得一种或多种候选物的步骤，测试一种或多种候选物质以确定其调节14-3-3ζ的表达和/或功能的能力， 选择确定调节14-3-3ζ的表达和/或功能的候选物质，并制备包含所选候选物质的药物组合物。 此外，公开了通过本发明所述的方法制备药剂并且将药剂施用于受试者的治疗患有过度​​增殖性疾病的受试者的方法。 过度增生性疾病可以是癌症，例如乳腺癌。

公开(公告)号：US20050148532A1

公开(公告)日：2005-07-07

申请号：US10938387

申请日：2004-09-10

申请人： Dihua Yu ,  Jun Yao ,  Christopher Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina Nguyen

发明人： Dihua Yu ,  Jun Yao ,  Christopher Neal ,  Wentao Yang ,  Xiaoyan Zhou ,  Raphael Pollock ,  Mien-Chie Hung ,  Jun Yang ,  Ping Li ,  Nina Nguyen

IPC分类号： A61K20060101 ,  A61K48/00 ,  C12Q1/68 ,  G01N33/574

CPC分类号： G01N33/574 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/178

摘要： Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more candidate substances to determine their ability to modulate the expression and/or function of 14-3-3 zeta, selecting a candidate substance determined to modulate the expression and/or function of 14-3-3 zeta, and making a pharmaceutical composition that includes the selected candidate substance. In addition, methods of treating a subject with a hyperproliferative disease, including making a pharmaceutical agent by the methods set forth herein, and administering the pharmaceutical agent to a subject, are disclosed. The hyperproliferative disease can be cancer, such as breast cancer.

摘要翻译： 公开了确定患有过度增生性疾病的受试者的预后的方法，包括确定受试者中14-3-3ζ的表达和/或功能。 还公开了制备调节凋亡的药剂的方法，包括获得一种或多种候选物的步骤，测试一种或多种候选物质以确定其调节14-3-3ζ的表达和/或功能的能力， 选择确定调节14-3-3ζ的表达和/或功能的候选物质，并制备包含所选候选物质的药物组合物。 此外，公开了通过本发明所述的方法制备药剂并且将药剂施用于受试者的治疗患有过度​​增殖性疾病的受试者的方法。 过度增生性疾病可以是癌症，例如乳腺癌。

公开(公告)号：US20240052967A1

公开(公告)日：2024-02-15

申请号：US17983667

申请日：2022-11-09

申请人： Guochen Pan ,  Jun Yang ,  Hong Wang

发明人： Guochen Pan ,  Jun Yang ,  Hong Wang

IPC分类号： F16M11/04 ,  F16M11/32 ,  G03B17/56

CPC分类号： F16M11/04 ,  F16M11/32 ,  G03B17/561

摘要： The invention discloses an adjusting structure and a stand for photographic apparatus. The adjusting structure includes a first adjusting rod, a first connecting member, a second connecting member, a second adjusting rod, a first locking member and a supporting member. The first connecting member is fixedly connected with the first adjusting rod, the second connecting member is rotationally connected with the first connecting member and is provided with a first mounting hole, wherein the second connecting member can be rotated relative to the first connecting member to adjust an included angle with the first connecting member, the second adjusting rod is penetrated through the first mounting hole and movablely connected with the first adjusting rod, and can be moved relative to the first adjusting rod along a straight direction.

公开(公告)号：US10660217B2

公开(公告)日：2020-05-19

申请号：US15993351

申请日：2018-05-30

申请人： Jun Yang ,  Tengyuan Zhang ,  Qiuquan Guo

发明人： Jun Yang ,  Tengyuan Zhang ,  Qiuquan Guo

IPC分类号： C23C18/16 ,  C23C18/40 ,  C23C18/30 ,  C23C18/28 ,  C23C18/20 ,  H05K3/42 ,  H05K1/03 ,  H05K3/12 ,  H05K1/09 ,  H05K3/18 ,  H05K3/38 ,  H05K1/18

摘要： Provided herein is a method to printed electronics, and more particularly related to printed electronics on flexible, porous substrates. The method includes applying a coating compound comprising poly (4-vinylpyridine) (P4VP) and SU-8 dissolved in an organic alcohol solution to one or more surface of a flexible, porous substrate, curing the porous substrate at a temperature of at least 130° C. such that the porous substrate is coated with a layer of said coating compound, printing a jet of a transition metal salt catalyst solution onto one or more printing sides of the flexible, porous substrate to deposit a transition metal salt catalyst onto the one or more printing sides, and submerging the substrate in an electroless metal deposition solution to deposit the metal on the flexible, porous substrate, wherein the deposited metal induces the formation of one or more three-dimensional metal-fiber conductive structures within the flexible, porous substrate.

公开(公告)号：US10593554B2

公开(公告)日：2020-03-17

申请号：US15941839

申请日：2018-03-30

申请人： Jun Yang

发明人： Jun Yang

IPC分类号： H01L21/67 ,  H01L21/687 ,  G02F1/13 ,  H01L21/306 ,  H01L21/3105 ,  H01L21/683 ,  B24B37/10 ,  B24B37/005 ,  G05B19/418 ,  H01L21/66 ,  H01L21/02 ,  B24B37/20

摘要： A method and apparatus for within-wafer profile localized tuning is disclosed. In one aspect, the method includes providing a wafer attached to a rotating vacuum stage front side up, the wafer including a surface film with an incoming film thickness profile, providing a pad attached to a rotating head front side down, the head configured to sweep along a path, computing a film thickness removal amount based upon the incoming film thickness profile, and removing at least a portion of the surface film of the wafer based on the computed film thickness removal amount via a plurality of steps.

公开(公告)号：US20180226263A1

公开(公告)日：2018-08-09

申请号：US15941839

申请日：2018-03-30

申请人： Jun Yang

发明人： Jun Yang

IPC分类号： H01L21/3105 ,  H01L21/683 ,  H01L21/687 ,  G05B19/418 ,  B24B37/10 ,  B24B37/005

摘要： A method and apparatus for within-wafer profile localized tuning is disclosed. In one aspect, the method includes providing a wafer attached to a rotating vacuum stage front side up, the wafer including a surface film with an incoming film thickness profile, providing a pad attached to a rotating head front side down, the head configured to sweep along a path, computing a film thickness removal amount based upon the incoming film thickness profile, and removing at least a portion of the surface film of the wafer based on the computed film thickness removal amount via a plurality of steps.

公开(公告)号：US09748573B2

公开(公告)日：2017-08-29

申请号：US14236878

申请日：2012-08-03

申请人： Jun Yang ,  Pengfei Gao ,  Jingjun Zhang ,  Longjie Zhou

发明人： Jun Yang ,  Pengfei Gao ,  Jingjun Zhang ,  Longjie Zhou

IPC分类号： H01M4/36 ,  H01M4/38 ,  H01M4/04 ,  H01M4/62 ,  H01M4/583 ,  C01B33/00 ,  C01B33/06 ,  H01M4/587 ,  H01M4/1395 ,  H01M10/052

CPC分类号： H01M4/583 ,  C01B33/00 ,  C01B33/06 ,  H01M4/0428 ,  H01M4/0471 ,  H01M4/1395 ,  H01M4/364 ,  H01M4/366 ,  H01M4/386 ,  H01M4/587 ,  H01M4/625 ,  H01M10/052

摘要： A mesoporous silicon compound includes a mesoporous silicon phase, a metal silicide phase, and a carbon phase. The metal silicide is embedded in mesoporous silicon particles, the surfaces of which are coated with a carbon layer. A weight ratio of elemental silicon to the metal element is from 2:3 to 900:1. The pores of the mesoporous silicon particles have a size distribution from two nanometers to eighty nanometers.

公开(公告)号：US09663860B2

公开(公告)日：2017-05-30

申请号：US14005791

申请日：2012-03-17

申请人： Jun Yang ,  Pengfei Gao ,  Haiping Jia ,  Jiulin Wang ,  Yanna Nuli

发明人： Jun Yang ,  Pengfei Gao ,  Haiping Jia ,  Jiulin Wang ,  Yanna Nuli

IPC分类号： H01M4/36 ,  C23C18/12 ,  H01M4/133 ,  H01M4/134 ,  H01M4/1393 ,  H01M4/1395 ,  H01M10/052 ,  H01M4/38 ,  H01M4/587 ,  C23C16/26

CPC分类号： C23C18/1275 ,  C23C16/26 ,  H01M4/133 ,  H01M4/134 ,  H01M4/1393 ,  H01M4/1395 ,  H01M4/366 ,  H01M4/386 ,  H01M4/587 ,  H01M10/052

摘要： Disclosed in the invention are a silicon-carbon composite anode material for lithium ion batteries and a preparation method thereof The material consists of a porous silicon substrate and a carbon coating layer. The preparation method of the material comprises preparing a porous silicon substrate and a carbon coating layer. The silicon-carbon composite anode material for lithium ion batteries has the advantages of high reversible capacity, good cycle performance and good rate performance. The material respectively shows reversible capacities of 1,556 mAh, 1,290 mAh, 877 mAh and 474 mAh/g at 0.2 C, 1 C, 4 C and 15 C rates; the specific capacity remains above 1,500 mAh after 40 cycles at the rate of 0.2 C and the reversible capacity retention rate is up to 90 percent.