公开(公告)号：US09809583B2

公开(公告)日：2017-11-07

申请号：US15305929

申请日：2015-04-07

申请人： DONG-A ST CO., LTD.

发明人： Sung Pil Choi ,  Seul Min Choi ,  Byoung Hwa Son ,  Hyun Jung Kim ,  Ju Mi Kim ,  Byung Jun Jang ,  Ji Hyun Sung ,  Ji Hye Lee ,  Eunjin Kim ,  Kyung Koo Kang ,  Soon-Hoe Kim

IPC分类号： C07D413/12 ,  C07D413/06 ,  C07D263/04 ,  C07D263/06 ,  A61K31/421

CPC分类号： C07D413/12 ,  A61K31/421 ,  C07D263/04 ,  C07D263/06 ,  C07D413/06

摘要： Provided are novel selective androgen receptor agonists, a preparation method thereof, and a pharmaceutical composition including the same at a pharmaceutically effective amount. The selective androgen receptor agonists according to the present invention act on androgen receptors to increase androgen activity, thereby being usefully applied as a therapeutic and prophylactic agent for diseases or conditions, of which symptoms may be improved or may respond to treatment by increased activities of androgen receptors, namely, a variety of hormone-related diseases in male and female, muscle wasting disorders, osteoporosis, etc.

公开(公告)号：US20170050955A1

公开(公告)日：2017-02-23

申请号：US15305929

申请日：2015-04-07

申请人： DONG-A ST CO., LTD.

发明人： Sung Pil Choi ,  Seul Min Choi ,  Byoung Hwa Son ,  Hyun Jung Kim ,  Ju Mi Kim ,  Byung Jun Jang ,  Ji Hyun Sung ,  Ji Hye Lee ,  Eunjin Kim ,  Kyung Koo Kang ,  Soon-Hoe Kim

IPC分类号： C07D413/12 ,  C07D263/04 ,  C07D413/06 ,  C07D263/06

CPC分类号： C07D413/12 ,  A61K31/421 ,  C07D263/04 ,  C07D263/06 ,  C07D413/06

摘要： Provided are novel selective androgen receptor agonists, a preparation method thereof, and a pharmaceutical composition including the same at a pharmaceutically effective amount. The selective androgen receptor agonists according to the present invention act on androgen receptors to increase androgen activity, thereby being usefully applied as a therapeutic and prophylactic agent for diseases or conditions, of which symptoms may be improved or may respond to treatment by increased activities of androgen receptors, namely, a variety of hormone-related diseases in male and female, muscle wasting disorders, osteoporosis, etc.

摘要翻译： 本发明提供新颖的选择性雄激素受体激动剂，其制备方法和药学组合物，其药物组合物含有药学有效量。 根据本发明的选择性雄激素受体激动剂作用于雄激素受体以增加雄激素活性，从而有效地应用于疾病或病症的治疗和预防剂，其症状可以改善或可能通过增加雄激素的活性来治疗 受体，即男性和女性各种激素相关疾病，肌肉消瘦疾病，骨质疏松症等。