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1.发明申请OXAZOLIDINE-BASED COMPOUND AND SELECTIVE ANDROGEN RECEPTOR AGONIST COMPRISING SAME 有权基于氧化氮的化合物和包含其的选择性原始受体激动剂公开(公告)号：US20170050955A1
公开(公告)日：2017-02-23
申请号：US15305929
申请日：2015-04-07
申请人： DONG-A ST CO., LTD.
发明人： Sung Pil Choi , Seul Min Choi , Byoung Hwa Son , Hyun Jung Kim , Ju Mi Kim , Byung Jun Jang , Ji Hyun Sung , Ji Hye Lee , Eunjin Kim , Kyung Koo Kang , Soon-Hoe Kim
IPC分类号： C07D413/12 , C07D263/04 , C07D413/06 , C07D263/06
CPC分类号： C07D413/12 , A61K31/421 , C07D263/04 , C07D263/06 , C07D413/06
摘要： Provided are novel selective androgen receptor agonists, a preparation method thereof, and a pharmaceutical composition including the same at a pharmaceutically effective amount. The selective androgen receptor agonists according to the present invention act on androgen receptors to increase androgen activity, thereby being usefully applied as a therapeutic and prophylactic agent for diseases or conditions, of which symptoms may be improved or may respond to treatment by increased activities of androgen receptors, namely, a variety of hormone-related diseases in male and female, muscle wasting disorders, osteoporosis, etc.
摘要翻译： 本发明提供新颖的选择性雄激素受体激动剂，其制备方法和药学组合物，其药物组合物含有药学有效量。 根据本发明的选择性雄激素受体激动剂作用于雄激素受体以增加雄激素活性，从而有效地应用于疾病或病症的治疗和预防剂，其症状可以改善或可能通过增加雄激素的活性来治疗 受体，即男性和女性各种激素相关疾病，肌肉消瘦疾病，骨质疏松症等。
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2.发明申请NOVEL OXAZOLIDINONE DERIVATIVE AS CETP INHIBITOR, ITS PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权新型氧杂环丁酮衍生物作为CETP抑制剂，其制备方法和包含其的药物组合物公开(公告)号：US20160039804A1
公开(公告)日：2016-02-11
申请号：US14779534
申请日：2014-03-28
申请人： DONG-A ST CO., LTD.
发明人： Jang Hyun Park , Seung Hyun Song , Han Kook Chung , Heung Jae Kim , Ji Hye Lee , Byung Jun Jang , Eun Jung Kim , Hae Hum Jung , Chae Lim Ryu , Jae-Sung Hwang , Hyung Ki Lee , Kyung Koo Kang , Soon-Hoe Kim
IPC分类号： C07D413/06 , C07D417/14 , C07D413/14
CPC分类号： C07D413/06 , C07D413/14 , C07D417/14
摘要： Disclosed are a novel oxazolidinone derivative exhibiting inhibitory activity against CETP, a preparation method thereof, and a pharmaceutical composition comprising the same. Exhibiting excellent inhibitory activity against CETP, the oxazolidinone derivative can be effectively applied to the prevention or treatment of various CETP enzyme activity- or HDL cholesterol level-related diseases such as dyslipidemia, atherosclerosis, and coronary heart disease.
摘要翻译： 公开了一种对CETP具有抑制活性的新型恶唑烷酮衍生物及其制备方法，以及含有该恶唑烷酮衍生物的药物组合物。 对恶唑烷酮衍生物具有优异的抑制活性，恶唑烷酮衍生物可有效应用于预防或治疗各种CETP酶活性或HDL胆固醇水平相关疾病，如血脂异常，动脉粥样硬化和冠心病。
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公开(公告)号：US10813973B2
公开(公告)日：2020-10-27
申请号：US15484067
申请日：2017-04-10
申请人： DONG-A ST CO., LTD.
发明人： Soon-Hoe Kim , Mi-Won Son , Sang-Zin Choi , Hye-Ju Kim , Ja-Young Ryu , Sun-Yeou Kim
IPC分类号： A61K36/8945 , A23L33/105 , A23L2/52 , A61K9/00 , A61K9/08 , A61K9/20 , A61K9/48
摘要： Disclosed are a pharmaceutical composition and a health functional food for the prevention and treatment of diabetic peripheral neuropathy, comprising an herb extract of a mixture of 3.5:1 Dioscorea Rhizoma:Dioscorea nipponica (w/w). Having the ability to synergistically increase in vivo levels of nerve growth factor, compared to the extracts from the herbs alone or herb mixtures of other weight ratios, the mixed herb extract is effective for preventing the apoptosis of nerve cells and promoting nerve regeneration. Thus, it can be applied to pharmaceutical compositions and health functional foods preventive and curative of diabetic peripheral neuropathy.
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4.发明授权公开(公告)号：US10709752B2
公开(公告)日：2020-07-14
申请号：US15484034
申请日：2017-04-10
申请人： DONG-A ST CO., LTD.
发明人： Soon-Hoe Kim , Mi-Won Son , Sang-Zin Choi , Hye-Ju Kim , Ja-Young Ryu , Sun-Yeou Kim
IPC分类号： A61K36/8945 , A23L33/105 , A23L2/52 , A61K9/00 , A61K9/08 , A61K9/20 , A61K9/48
摘要： This invention relates to a pharmaceutical composition and a health functional food for preventing or improving neurodegenerative disorders comprising mixed herb extracts of Dioscorea Rhizoma and Dioscorea nipponica in a weight ratio of 3.5:1 (w/w). The herb extracts mixed Dioscorea Rhizoma and Dioscorea nipponica in a weight ratio of 3.5:1 have the synergetic effects on increasing the amount of nerve growth factor in vivo, increasing the neural cell proliferation, promoting the formation of neuritis and enhancing cognitive abilities. Thus, the herb extracts of the present invention may be used for a pharmaceutical composition and a health functional food for preventing or treating neurodegenerative disorders.
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公开(公告)号：US09809583B2
公开(公告)日：2017-11-07
申请号：US15305929
申请日：2015-04-07
申请人： DONG-A ST CO., LTD.
发明人： Sung Pil Choi , Seul Min Choi , Byoung Hwa Son , Hyun Jung Kim , Ju Mi Kim , Byung Jun Jang , Ji Hyun Sung , Ji Hye Lee , Eunjin Kim , Kyung Koo Kang , Soon-Hoe Kim
IPC分类号： C07D413/12 , C07D413/06 , C07D263/04 , C07D263/06 , A61K31/421
CPC分类号： C07D413/12 , A61K31/421 , C07D263/04 , C07D263/06 , C07D413/06
摘要： Provided are novel selective androgen receptor agonists, a preparation method thereof, and a pharmaceutical composition including the same at a pharmaceutically effective amount. The selective androgen receptor agonists according to the present invention act on androgen receptors to increase androgen activity, thereby being usefully applied as a therapeutic and prophylactic agent for diseases or conditions, of which symptoms may be improved or may respond to treatment by increased activities of androgen receptors, namely, a variety of hormone-related diseases in male and female, muscle wasting disorders, osteoporosis, etc.
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公开(公告)号：US20160168167A1
公开(公告)日：2016-06-16
申请号：US14908006
申请日：2014-07-28
申请人： DONG-A ST CO., LTD.
发明人： Soon-Hoe Kim , Weon-Bin Im , Seung-Bum Ha , Jung-Sang Park , Mi-Yeon Kim , Sung-Hak Choi , Hyun-Jung Sung
IPC分类号： C07F5/02
摘要： The present invention relates to a novel tricyclic benzoxaborole derivative, a preparation method thereof, and use of antibiotics pharmaceutical composition including the same as an active ingredient.
摘要翻译： 本发明涉及一种新型的三环苯并恶灵衍生物及其制备方法，以及使用包含其的活性成分的抗生素药物组合物。
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公开(公告)号：US10398747B2
公开(公告)日：2019-09-03
申请号：US16034288
申请日：2018-07-12
申请人： DONG-A ST CO., LTD.
发明人： Soon-Hoe Kim , Mi-Won Son , Sang-Zin Choi , Hye-Ju Kim , Ja-Young Ryu , Sun-Yeou Kim
IPC分类号： A61K36/8945 , A23L33/105 , A23L2/52 , A61K9/00 , A61K9/08 , A61K9/20 , A61K9/48
摘要： Disclosed are a pharmaceutical composition and a health functional food for the prevention and treatment of diabetic peripheral neuropathy, comprising an herb extract of a mixture of 3.5:1 Dioscorea Rhizoma:Dioscorea nipponica (w/w). Having the ability to synergistically increase in vivo levels of nerve growth factor, compared to the extracts from the herbs alone or her mixtures of other weight ratios, the mixed herb extract is effective for preventing the apoptosis of nerve cells and promoting nerve regeneration. Thus, it can be applied to pharmaceutical compositions and health function foods preventive and curative of diabetic peripheral neuropathy.
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公开(公告)号：US09828339B2
公开(公告)日：2017-11-28
申请号：US14909096
申请日：2014-07-17
申请人： DONG-A ST CO., LTD
发明人： Soon-Hoe Kim , Weon-Bin Im , Chong-Hwan Cho , Sun-Ho Choi , Jung-Sang Park , Mi-Yeon Kim , Sung-Hak Choi , Min-Jung Lee , Kang-Hun Cho
IPC分类号： C07D207/08
CPC分类号： C07D207/08
摘要： Provided are biphenyl derivatives having the structure of Formula 1: stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen, halogen, hydroxy, substituted or unsubstituted C1-C6 alkyl, or C1-C6 alkoxy; R2, R3 and R4 are each independently hydrogen, halogen, substituted or unsubstituted amino, nitro, cyano, hydroxy, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkoxy, or —C(O)R6; R5 is hydrogen or C1-C6 alkyl; n is 0 or 1; and R6 is hydrogen or amino, methods for preparing the same, and a pharmaceutical composition containing the same. The biphenyl derivatives having the structure of Formula 1 act as muscarinic M3 receptor antagonists, and thus are useful for the prevention or treatment of a disease selected from among chronic obstructive pulmonary disease, asthma, irritable bowel syndrome, urinary incontinence, rhinitis, spasmodic colitis, chronic cystitis, Alzheimer's disease, senile dementia, glaucoma, schizophrenia, gastroesophageal reflux disease, cardiac arrhythmia, and hyper-salivation syndromes.
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公开(公告)号：US09676796B2
公开(公告)日：2017-06-13
申请号：US14908006
申请日：2014-07-28
申请人： DONG-A ST CO., LTD.
发明人： Soon-Hoe Kim , Weon-Bin Im , Seung-Bum Ha , Jung-Sang Park , Mi-Yeon Kim , Sung-Hak Choi , Hyun-Jung Sung
摘要： The present invention relates to a novel tricyclic benzoxaborole derivative, a preparation method thereof, and use of antibiotics pharmaceutical composition including the same as an active ingredient.
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10.发明授权Oxazolidinone derivative as CETP inhibitor, its preparation method, and pharmaceutical composition comprising the same 有权恶唑烷酮衍生物作为CETP抑制剂，其制备方法和包含其的药物组合物公开(公告)号：US09533977B2
公开(公告)日：2017-01-03
申请号：US14779534
申请日：2014-03-28
申请人： DONG-A ST CO., LTD.
发明人： Jang Hyun Park , Seung Hyun Song , Han Kook Chung , Heung Jae Kim , Ji Hye Lee , Byung Jun Jang , Eun Jung Kim , Hae Hum Jung , Chae Lim Ryu , Jae-Sung Hwang , Hyung Ki Lee , Kyung Koo Kang , Soon-Hoe Kim
IPC分类号： C07D413/06 , C07D413/14 , C07D417/14
CPC分类号： C07D413/06 , C07D413/14 , C07D417/14
摘要： Disclosed are a novel oxazolidinone derivative exhibiting inhibitory activity against CETP, a preparation method thereof, and a pharmaceutical composition comprising the same. Exhibiting excellent inhibitory activity against CETP, the oxazolidinone derivative can be effectively applied to the prevention or treatment of various CETP enzyme activity- or HDL cholesterol level-related diseases such as dyslipidemia, atherosclerosis, and coronary heart disease.
摘要翻译： 公开了一种对CETP具有抑制活性的新型恶唑烷酮衍生物及其制备方法，以及含有该恶唑烷酮衍生物的药物组合物。 对恶唑烷酮衍生物具有优异的抑制活性，恶唑烷酮衍生物可有效应用于预防或治疗各种CETP酶活性或HDL胆固醇水平相关疾病，如血脂异常，动脉粥样硬化和冠心病。
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