公开(公告)号：US11992562B2

公开(公告)日：2024-05-28

申请号：US16957774

申请日：2018-11-07

申请人： DONG-A ST CO., LTD. ,  KM TRANSDERM LTD.

发明人： Sun-Woo Jang ,  Chang-Yell Shin ,  Jeong-Soo Kim ,  Hae-Sun Kim ,  Kwang-Ho Cha ,  Hyun-Jung Kim ,  Masaoki Goto

IPC分类号： A61K9/70 ,  A61F13/02 ,  A61K31/445 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/44 ,  B29D7/01 ,  B29K71/00 ,  B29L31/00

CPC分类号： A61K9/7084 ,  A61F13/0276 ,  A61K31/445 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/44 ,  A61F2013/0296 ,  B29D7/01 ,  B29K2071/02 ,  B29L2031/753

摘要： A percutaneous absorption preparation is disclosed. The percutaneous absorption preparation contains donepezil for treatment of dementia, wherein the preparation includes: (a) donepezil or its pharmaceutically acceptable salt as active component, (b) propylene glycol monocaprylate as solubilizer, and (c) styrene-isoprene-styrene block copolymer (“SIS”) as adhesive. The percutaneous absorption preparation has low skin irritation and high skin penetration.