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公开(公告)号：US09499787B2
公开(公告)日：2016-11-22
申请号：US14377160
申请日：2013-02-05
发明人： Jung Keug Park , Hee Hoon Yoon , Soo Yeon Kim , Young Kwon Seo
IPC分类号： C12N5/079
CPC分类号： C12N5/0618 , C12N2500/44 , C12N2501/33 , C12N2501/39 , C12N2501/999 , C12N2506/1346 , C12N2506/1384
摘要： The present invention relates to a method for differentiating stem cells into neurons, and is characterized in that stem cells are treated with a culture additive comprising lipoic acid, albumin, hydrocortisone, and insulin after culturing for differentiation into neurons. Since the neurons produced according to the method for producing neurons of the present invention express nestin, neuroD1, neuron-specific enolase (NSE), neurofilament (NF), tau, microtubule-associated protein 2 (MAP2), and doublecortin (DCX), just as normal mature neurons do, the neurons of the present invention can be effectively used in various therapeutic agents for neurons and as cell origins for an in vitro study system.
摘要翻译： 本发明涉及一种将干细胞分化为神经元的方法，其特征在于，在培养后分化为神经元的干细胞用包含硫辛酸，白蛋白，氢化可的松和胰岛素的培养添加剂进行处理。 由于根据本发明的神经元的制造方法产生的神经元表达巢蛋白，神经元D1，神经元特异性烯醇化酶（NSE），神经丝（NF），tau，微管相关蛋白2（MAP2）和双皮质素（DCX） 正如正常的成熟神经元那样，本发明的神经元可以有效地用于神经元的各种治疗剂和用于体外研究系统的细胞来源。
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公开(公告)号：US20160206778A1
公开(公告)日：2016-07-21
申请号：US14936406
申请日：2015-11-09
发明人： Jung-Keug Park , Young Kwon Seo , Mi Jung Han , Hwa Sung Lee , Su Rak Eo , Hee Hoon Yoon , Soon Yong Kwon , Hee Jung Park
CPC分类号： A61L27/24 , A61F2/02 , A61F2/08 , A61F2240/001 , A61L27/32 , A61L27/54 , A61L2300/414 , A61L2430/10 , A61L2430/30 , D03D15/00 , D06B1/00
摘要： Embodiments of the present invention relate to a biodegradable scaffold for replacing tissue or inducing tissue regeneration and a preparation method thereof, wherein the scaffold comprises at least one woven silk tube layer and a collagen layer inside the tube layer. The scaffold is excellent in terms of tissue regeneration and mechanical properties and causes little or no immune response after implantation. Thus, the scaffold can be effectively used as a matrix for the regeneration of ligaments and tendons and the repair of injured muscles.
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公开(公告)号：US20150004701A1
公开(公告)日：2015-01-01
申请号：US14377160
申请日：2013-02-05
发明人： Jung Keug Park , Hee Hoon Yoon , Soo Yeon Kim , Young Kwon Seo
IPC分类号： C12N5/079
CPC分类号： C12N5/0618 , C12N2500/44 , C12N2501/33 , C12N2501/39 , C12N2501/999 , C12N2506/1346 , C12N2506/1384
摘要： The present invention relates to a method for differentiating stem cells into neurons, and is characterized in that stem cells are treated with a culture additive comprising lipoic acid, albumin, hydrocortisone, and insulin after culturing for differentiation into neurons. Since the neurons produced according to the method for producing neurons of the present invention express nestin, neuroD1, neuron-specific enolase (NSE), neurofilament (NF), tau, microtubule-associated protein 2 (MAP2), and doublecortin (DCX), just as normal mature neurons do, the neurons of the present invention can be effectively used in various therapeutic agents for neurons and as cell origins for an in vitro study system.
摘要翻译： 本发明涉及一种将干细胞分化为神经元的方法，其特征在于，在培养后分化为神经元的干细胞用包含硫辛酸，白蛋白，氢化可的松和胰岛素的培养添加剂进行处理。 由于根据本发明的神经元的制造方法产生的神经元表达巢蛋白，神经元D1，神经元特异性烯醇化酶（NSE），神经丝（NF），tau，微管相关蛋白2（MAP2）和双皮质素（DCX） 正如正常的成熟神经元那样，本发明的神经元可以有效地用于神经元的各种治疗剂和用于体外研究系统的细胞来源。
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