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    METHODS FOR DISEASE ASSESSMENT USING DRAIN FLUID
    1.
    发明申请
    METHODS FOR DISEASE ASSESSMENT USING DRAIN FLUID 有权

    公开(公告)号：US20230131016A1

    公开(公告)日：2023-04-27

    申请号：US18087148

    申请日：2022-12-22

    申请人： DROPLET BIOSCIENCES, INC.

    发明人： Jose P. Zevallos ,  Aadel Chaudhuri ,  Stanley N. Lapidus ,  Theresa Tribble

    IPC分类号： C12Q1/6886

    摘要： The present invention provides methods for using surgical drainage waste fluid as a means for diagnosing disease, assessing disease progression, predicting metastatic disease, assessing cancer metastasis, disease staging, molecular staging, and assessing metastatic disease. During surgery, suction is used to drain fluids such as blood, tissue fluids, and other bodily fluids away from the surgery site. The suction drainage fluid waste, also called drain fluid, is removed from the patient during the surgical procedure. Because surgical drain fluid is typically viewed as something that is not useful, it is disregarded and thrown away during the surgery. Instead, the invention provides that drain fluid, which is mostly lymphatic fluid and interstitial fluid, is diagnostically rich and contains important information for assessing, diagnosing, and treating disease. The methods of the invention use this waste fluid for the valuable data it contains. Therefore, while a patient is already undergoing surgery for a medical condition, the waste drain fluid is sampled and analyzed for biomarkers or other molecular indicia of disease.

    TUMOR PROXIMAL CELL COLLECTION
    3.
    发明公开
    TUMOR PROXIMAL CELL COLLECTION 审中-公开

    公开(公告)号：US20240200030A1

    公开(公告)日：2024-06-20

    申请号：US18542322

    申请日：2023-12-15

    申请人： DROPLET BIOSCIENCES, INC.

    发明人： Wendy Winckler Adamovich ,  Theresa Tribble

    IPC分类号： C12N5/0783

    CPC分类号： C12N5/0636 ,  C12N2501/2302 ,  C12N2501/999 ,  C12N2502/1157

    摘要： The invention provides methods of preparing a cell therapy by collecting fluid from a site proximal to a tumor and expanding T cells obtained from the fluid. Methods include collecting fluid from a site proximal to a tumor, obtaining at least one T cell from the fluid, and culturing the T cells in vitro. The fluid may be collected during or after surgical removal of a tumor from the site of the surgical removal of the tumor. The fluid may be drain fluid that drains from a surgical site. The method may include diverting the fluid from a waste disposal protocol or vessel in a surgical theater and into a collection vessel. Preferably the fluid includes lymphatic fluid.

    THERAPEUTIC EVALUATION
    4.
    发明公开
    THERAPEUTIC EVALUATION 审中-公开

    公开(公告)号：US20240027427A1

    公开(公告)日：2024-01-25

    申请号：US18083400

    申请日：2022-12-16

    申请人： DROPLET BIOSCIENCES, INC.

    发明人： Jose P. Zevallos ,  Aadel Chaudhuri ,  Theresa Tribble

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5011 ,  G01N2500/10

    摘要： The present invention provides methods for using waste effluent biofluids in cell culture assays as all or part of the cell culture microenvironment. Methods of the invention contemplate that biofluids typically regarded as waste may be used in cell-based assays to achieve a cell culture microenvironment that provides a novel understanding of cellular response.

    METHODS FOR DISEASE ASSESSMENT USING DRAIN FLUID
    5.
    发明申请
    METHODS FOR DISEASE ASSESSMENT USING DRAIN FLUID 有权

    公开(公告)号：US20230092508A1

    公开(公告)日：2023-03-23

    申请号：US17947861

    申请日：2022-09-19

    申请人： DROPLET BIOSCIENCES, INC. ,  THE WASHINGTON UNIVERSITY

    发明人： Jose P. Zevallos ,  Aadel Chaudhuri ,  Stanley N. Lapidus ,  Theresa Tribble

    IPC分类号： G01N33/50 ,  C12Q1/6886

    摘要： The present invention provides methods for using surgical drainage waste fluid as a means for diagnosing disease, assessing disease progression, predicting metastatic disease, assessing cancer metastasis, disease staging, molecular staging, and assessing metastatic disease. During surgery, suction is used to drain fluids such as blood, tissue fluids, and other bodily fluids away from the surgery site. The suction drainage fluid waste, also called drain fluid, is removed from the patient during the surgical procedure. Because surgical drain fluid is typically viewed as something that is not useful, it is disregarded and thrown away during the surgery. Instead, the invention provides that drain fluid, which is mostly lymphatic fluid and interstitial fluid, is diagnostically rich and contains important information for assessing, diagnosing, and treating disease. The methods of the invention use this waste fluid for the valuable data it contains. Therefore, while a patient is already undergoing surgery for a medical condition, the waste drain fluid is sampled and analyzed for biomarkers or other molecular indicia of disease.