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    METHODS FOR DISEASE ASSESSMENT USING DRAIN FLUID
    2.
    发明申请
    METHODS FOR DISEASE ASSESSMENT USING DRAIN FLUID 有权

    公开(公告)号：US20230092508A1

    公开(公告)日：2023-03-23

    申请号：US17947861

    申请日：2022-09-19

    申请人： DROPLET BIOSCIENCES, INC. ,  THE WASHINGTON UNIVERSITY

    发明人： Jose P. Zevallos ,  Aadel Chaudhuri ,  Stanley N. Lapidus ,  Theresa Tribble

    IPC分类号： G01N33/50 ,  C12Q1/6886

    摘要： The present invention provides methods for using surgical drainage waste fluid as a means for diagnosing disease, assessing disease progression, predicting metastatic disease, assessing cancer metastasis, disease staging, molecular staging, and assessing metastatic disease. During surgery, suction is used to drain fluids such as blood, tissue fluids, and other bodily fluids away from the surgery site. The suction drainage fluid waste, also called drain fluid, is removed from the patient during the surgical procedure. Because surgical drain fluid is typically viewed as something that is not useful, it is disregarded and thrown away during the surgery. Instead, the invention provides that drain fluid, which is mostly lymphatic fluid and interstitial fluid, is diagnostically rich and contains important information for assessing, diagnosing, and treating disease. The methods of the invention use this waste fluid for the valuable data it contains. Therefore, while a patient is already undergoing surgery for a medical condition, the waste drain fluid is sampled and analyzed for biomarkers or other molecular indicia of disease.

    METHODS FOR DISEASE ASSESSMENT USING DRAIN FLUID
    4.
    发明申请
    METHODS FOR DISEASE ASSESSMENT USING DRAIN FLUID 有权

    公开(公告)号：US20230131016A1

    公开(公告)日：2023-04-27

    申请号：US18087148

    申请日：2022-12-22

    申请人： DROPLET BIOSCIENCES, INC.

    发明人： Jose P. Zevallos ,  Aadel Chaudhuri ,  Stanley N. Lapidus ,  Theresa Tribble

    IPC分类号： C12Q1/6886

    摘要： The present invention provides methods for using surgical drainage waste fluid as a means for diagnosing disease, assessing disease progression, predicting metastatic disease, assessing cancer metastasis, disease staging, molecular staging, and assessing metastatic disease. During surgery, suction is used to drain fluids such as blood, tissue fluids, and other bodily fluids away from the surgery site. The suction drainage fluid waste, also called drain fluid, is removed from the patient during the surgical procedure. Because surgical drain fluid is typically viewed as something that is not useful, it is disregarded and thrown away during the surgery. Instead, the invention provides that drain fluid, which is mostly lymphatic fluid and interstitial fluid, is diagnostically rich and contains important information for assessing, diagnosing, and treating disease. The methods of the invention use this waste fluid for the valuable data it contains. Therefore, while a patient is already undergoing surgery for a medical condition, the waste drain fluid is sampled and analyzed for biomarkers or other molecular indicia of disease.

    THERAPEUTIC EVALUATION
    8.
    发明公开
    THERAPEUTIC EVALUATION 审中-公开

    公开(公告)号：US20240027427A1

    公开(公告)日：2024-01-25

    申请号：US18083400

    申请日：2022-12-16

    申请人： DROPLET BIOSCIENCES, INC.

    发明人： Jose P. Zevallos ,  Aadel Chaudhuri ,  Theresa Tribble

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5011 ,  G01N2500/10

    摘要： The present invention provides methods for using waste effluent biofluids in cell culture assays as all or part of the cell culture microenvironment. Methods of the invention contemplate that biofluids typically regarded as waste may be used in cell-based assays to achieve a cell culture microenvironment that provides a novel understanding of cellular response.

    METHODS FOR CANCER TREATMENT
    9.
    发明申请
    METHODS FOR CANCER TREATMENT 有权

    公开(公告)号：US20230127134A1

    公开(公告)日：2023-04-27

    申请号：US18087165

    申请日：2022-12-22

    申请人： DROPLET BIOSCIENCES, INC.

    发明人： Jose P. Zevallos ,  Aadel Chaudhuri ,  Stanley N. Lapidus

    IPC分类号： A61M27/00

    摘要： The present invention relates to novel surgical drains and associated methods and systems. Specifically, the present invention includes a surgical drain with at least two ports. A first port drains lymphatic fluid from a subject for collection and analysis. The second port functions to introduce a therapeutic into the subject.