公开(公告)号：US11905542B2

公开(公告)日：2024-02-20

申请号：US16648872

申请日：2018-09-25

Applicant: DSM IP ASSETS B.V.

Inventor： Nathalie Balch ,  Paul Blomquist ,  Reed Doten ,  Peter Houston ,  Ethan Lam ,  Jenna McMahon ,  Joshua Trueheart ,  Celine Viarouge

IPC: C12P23/00

CPC classification number: C12P23/00

Abstract: The present invention is related to a novel enzymatic process for production of retinyl esters, such as in particular retinyl long chain esters, via conversion of retinol, which process includes the use of enzymes having acyltransferase activity. Said process might be used for biotechnological production of vitamin A.

公开(公告)号：US12252724B2

公开(公告)日：2025-03-18

申请号：US18161236

申请日：2023-01-30

Applicant: DSM IP ASSETS B.V.

Inventor： Nathalie Balch ,  Paul Blomquist ,  Reed Doten ,  Peter Houston ,  Ethan Lam ,  Jenna McMahon ,  Joshua Trueheart ,  Celine Viarouge

IPC: C12P7/22 ,  C12N9/04 ,  C12N9/10 ,  C12P7/62

Abstract: The present invention is related to a novel enzymatic process for production of retinoids via a multi-step process, which process includes the use of heterologous enzymes having activity in a carotene-producing host cell, particularly wherein such process results in high percentage of retinoids, in trans-isoform.

公开(公告)号：US11578344B2

公开(公告)日：2023-02-14

申请号：US16647730

申请日：2018-09-25

Applicant: DSM IP ASSETS B.V.

Inventor： Nathalie Balch ,  Paul Blomquist ,  Reed Doten ,  Peter Houston ,  Ethan Lam ,  Jenna McMahon ,  Joshua Trueheart ,  Celine Viarouge

IPC: C12P7/22 ,  C12N9/04 ,  C12N9/10 ,  C12P7/62

Abstract: The present invention is related to a novel enzymatic process for production of retinoids via a multi-step process, which process includes the use of heterologous enzymes having activity in a carotene-producing host cell, particularly wherein such process results in high percentage of retinoids, in trans-isoform.