公开(公告)号：US20210106565A1

公开(公告)日：2021-04-15

申请号：US17131739

申请日：2020-12-22

Applicant: DSM IP ASSETS B.V.

Inventor： Irmgard IMMIG ,  Wolfgang STEINBERG ,  Joseph MC GRATH

IPC: A61K31/4188 ,  A61K31/05 ,  A61K31/11 ,  A23K20/174 ,  A23K20/158 ,  A23K50/10 ,  A23K20/10 ,  A61K31/085

Abstract: Methods to prevent ketosis or minimize the effects of ketosis in ruminant animals are provided. This methods include feeding to the animal biotin in combination with a mixture of at least two essential oil compounds selected from the group consisting of thymol, eugenol, meta-cresol, vaniline and guajacol. The methods usefully prevent and/or inhibit ketosis of calving ruminant animals and the subsequent need for veterinary treatment. In a preferred embodiment of a feeding concept for dairy cattle, especially calving dairy cattle, biotin is used in an amount sufficient to provide a daily dosage of 10 mg to 20 mg per head to which it is to be administered. It is at present contemplated that the essential oils are administered in amounts (total dosage ranges of essential oils) of 1 to 1.5 g per head per day.

公开(公告)号：US20160317500A1

公开(公告)日：2016-11-03

申请号：US15102316

申请日：2014-12-11

Applicant: DSM IP ASSETS B.V.

Inventor： Irmgard IMMIG ,  Wolfgang STEINBERG ,  Joseph MC GRATH

IPC: A61K31/4188 ,  A61K31/085 ,  A23K20/174 ,  A23K50/10 ,  A23K20/158 ,  A61K31/05 ,  A61K31/11

CPC classification number: A61K31/4188 ,  A23K20/10 ,  A23K20/158 ,  A23K20/174 ,  A23K50/10 ,  A61K31/05 ,  A61K31/085 ,  A61K31/11 ,  A61K2300/00

Abstract: The present invention is made for the prevention of ketosis or minimizing the effects of ketosis in ruminant animals. This purpose is achieved by feeding to the animal biotin in combination with a mixture of at least two essential oil compounds selected from the group consisting of thymol, eugenol, meta-cresol, vaniline and guajacol. The present invention is useful because it is capable of preventing and/or inhibiting ketosis of calving ruminant animals and the subsequent need for veterinary treatment. In a preferred embodiment of a feeding concept for dairy cattle, especially calving dairy cattle, biotin being used in an amount sufficient to provide a daily dosage of 10 mg to 20 mg per head to which it is to be administered. It is at present contemplated that the essential oils are administered in amounts (total dosage ranges of essential oils) of 1 to 1.5 g per head per day.

Abstract translation: 本发明是为了预防酮症或使反刍动物中酮症的作用最小化。 该目的通过与至少两种选自百里香酚，丁子香酚，间甲酚，香草胺和瓜那醇的精油化合物的混合物联合给动物生物素来实现。 本发明是有用的，因为它能够预防和/或抑制产犊反刍动物的酮症和随后的兽医治疗需要。 在用于奶牛，特别是犊牛奶牛的喂养概念的优选实施方案中，生物素的用量足以提供每日10mg剂量至每头给予10mg。 目前预期精油以每天头数为1至1.5g的量（精油的总剂量范围）施用。

公开(公告)号：US20160310469A1

公开(公告)日：2016-10-27

申请号：US15102967

申请日：2014-12-11

Applicant: DSM IP ASSETS B.V.

Inventor： Irmgard IMMIG ,  Wolfgang STEINBERG ,  Joseph MC GRATH

IPC: A61K31/4188 ,  A23K20/174 ,  A61K31/05 ,  A61K9/00 ,  A61K31/085 ,  A61K31/11 ,  A23K50/10 ,  A23K20/158

CPC classification number: A61K31/4188 ,  A23K20/10 ,  A23K20/105 ,  A23K20/111 ,  A23K20/158 ,  A23K20/174 ,  A23K50/10 ,  A61K9/0056 ,  A61K31/05 ,  A61K31/085 ,  A61K31/11

Abstract: The present invention is made for the purpose of improving beef quality and upgrading its fat marbling standard (which is called beef marbling standard, or BMS). The fat marbling state is generally called “Shimofuri” in Japanese. This purpose is achieved by feeding to the animal biotin in combination with a mixture of at least two essential oil compounds selected from the group consisting of thymol, eugenol, meta-cresol, vaniline and guajacol. In a preferred embodiment of the invention, biotin is used in an amount sufficient to provide a daily dosage of 0.01 mg to 0.3 mg per kg body weight and the essential oils are administered in amounts (total dosage ranges of essential oils) of 0.5 to 4 mg per kg body weight per day. In terms of the quality of the meat, the combined use of biotin and the essential oils as defined above shows significant differences in the fat marbling (Shimofuri), luster, firmness and texture of the meat compared to the meat of non-treated animals.

Abstract translation: 本发明是为了提高牛肉质量和提高其大理石肥料标准（称为牛肉大理石标准或BMS）的目的。 肥胖的大理石花纹状态通常被称为日本的“Shimofuri”。 该目的通过与至少两种选自百里香酚，丁子香酚，间甲酚，香草胺和瓜那醇的精油化合物的混合物联合给动物生物素来实现。 在本发明的优选实施方案中，生物素的用量足以提供0.01mg至0.3mg / kg体重的日剂量，并且将精油以0.5至4的量（精油的总剂量范围）施用 mg / kg体重每天。 在肉的质量方面，如上所述，生物素和精油的组合使用显示了与未经处理的动物相比，肉的脂肪大理石（Shimofuri），光泽，坚实度和肉质的显着差异。

公开(公告)号：US20190083466A1

公开(公告)日：2019-03-21

申请号：US16194652

申请日：2018-11-19

Applicant: DSM IP ASSETS B.V.

Inventor： Irmgard IMMIG ,  Wolfgang STEINBERG ,  Joseph MC GRATH

IPC: A61K31/4188 ,  A61K31/11 ,  A61K31/085 ,  A61K31/05 ,  A61K9/00 ,  A23K20/174 ,  A23K20/10 ,  A23K20/158 ,  A23K20/111 ,  A23K20/105 ,  A23K50/10

Abstract: The present invention is made for the purpose of improving beef quality and upgrading its fat marbling standard (which is called beef marbling standard, or BMS). The fat marbling state is generally called “Shimofuri” in Japanese. This purpose is achieved by feeding to the animal biotin in combination with a mixture of at least two essential oil compounds selected from the group consisting of thymol, eugenol, meta-cresol, vanillin and guaiacol. In a preferred embodiment of the invention, biotin is used in an amount sufficient to provide a daily dosage of 0.01 mg to 0.3 mg per kg body weight and the essential oils are administered in amounts (total dosage ranges of essential oils) of 0.5 to 4 mg per kg body weight per day. In terms of the quality of the meat, the combined use of biotin and the essential oils as defined above shows significant differences in the fat marbling (Shimofuri), luster, firmness and texture of the meat compared to the meat of non-treated animals.