公开(公告)号：US20190314328A1

公开(公告)日：2019-10-17

申请号：US16453934

申请日：2019-06-26

Applicant: DSM IP ASSETS B.V.

Inventor： Szabolcs PETER ,  Joseph SCHWAGER

IPC: A61K31/355 ,  A23L33/15 ,  A23L33/12 ,  A61K31/202

Abstract: Mixtures of vitamin E and polyunsaturated fatty acids (PUFAs) are provided as agents for the prevention, control and/or treatment of conditions associated with excessive fat accumulation in the liver which is not caused by alcohol abuse, including control and/or treatment of non-alcoholic steatosis in the liver—known as non-alcoholic fatty liver disease (NAFLD)—and/or non-alcoholic steatohepatitis (NASH) in a subject in need thereof.

公开(公告)号：US20180000775A1

公开(公告)日：2018-01-04

申请号：US15536252

申请日：2015-12-14

Applicant: DSM IP ASSETS B.V.

Inventor： Szabolcs PETER ,  Joseph SCHWAGER

IPC: A61K31/355 ,  A61K31/202 ,  A23L33/12 ,  A23L33/15

CPC classification number: A61K31/355 ,  A23L33/12 ,  A23L33/15 ,  A23V2002/00 ,  A23V2250/1882 ,  A23V2250/712 ,  A61K31/202 ,  A61K2300/00 ,  A23V2200/32

Abstract: The present invention relates to the use of mixtures of vitamin E and polyunsaturated fatty acids (PUFAs) as agents for the prevention, control and/or treatment of conditions associated with excessive fat accumulation in the liver which is not caused by alcohol abuse. This includes prevention, control and/or treatment of non-alcoholic steatosis in the liver—known as non-alcoholic fatty liver disease (NAFLD)—and/or non-alcoholic steatohepatitis (NASH) in a subject in need thereof. In particular, the present invention relates to the use of such compounds comprising vitamin E and PUFAs as active ingredients in the manufacture of medicaments for the prevention, control and/or treatment of conditions related to NAFLD.

公开(公告)号：US20170106005A1

公开(公告)日：2017-04-20

申请号：US15393160

申请日：2016-12-28

Applicant: DSM IP ASSETS B.V.

Inventor： Stephanie KRAMMER-LUKAS ,  Elisabeth STOECKLIN ,  Joseph SCHWAGER ,  Swen WOLFRAM

IPC: A61K31/593 ,  A61K9/00 ,  A23L33/155 ,  A61K9/48

CPC classification number: A61K31/593 ,  A23L33/155 ,  A23V2002/00 ,  A61K9/0053 ,  A61K9/48 ,  A61K2300/00

Abstract: Methods for treating/preventing conditions associated with an increased level of eotaxin in a human with 25-hydroxyvitamin D3 (calcifediol) are provided. Optionally, vitamin D3 may be used together with 25-hydroxyvitamin D3.

公开(公告)号：US20160136108A1

公开(公告)日：2016-05-19

申请号：US15003777

申请日：2016-01-21

Applicant: DSM IP ASSETS B.V.

Inventor： Daniel RAEDERSTORFF ,  Joseph SCHWAGER ,  Karin WERTZ

IPC: A61K31/05

CPC classification number: A61K31/05 ,  A61K31/202 ,  A61K31/7004 ,  A61K31/737 ,  A61K2300/00

Abstract: The invention relates to the use of hydroxytyrosol for inducing or enhancing cartilage repair or cartilage regeneration. Furthermore, the invention relates to nutraceutical and pharmaceutical compositions comprising hydroxytyrosol for regeneration and repair of cartilage injuries in joints, in particular of traumatic cartilage injuries.

公开(公告)号：US20190054063A1

公开(公告)日：2019-02-21

申请号：US16166357

申请日：2018-10-22

Applicant: DSM IP ASSETS B.V.

Inventor： Szabolcs PETER ,  Joseph SCHWAGER ,  Weerasinghe M. INDRASENA ,  Jaroslav A. KRALOVEC ,  Bernd MUSSLER

IPC: A61K31/355 ,  A61K31/22 ,  A61P1/16

CPC classification number: A61K31/355 ,  A61K31/22 ,  A61P1/16

Abstract: The present invention relates to the use of mixtures of vitamin E and polyunsaturated fatty acids (PUFAs) as agents for the prevention, control and/or treatment of conditions associated with excessive fat accumulation in the liver which is not caused by alcohol abuse. This includes prevention, control and/or treatment of non-alcoholic steatosis in the liver—known as non-alcoholic fatty liver disease (NAFLD)—and/or non-alcoholic steatohepatitis (NASH) in a subject in need thereof. In particular, the present invention relates to the use of such compounds comprising vitamin E acetate and DHA EE as active ingredients in the manufacture of medicaments for the prevention, control and/or treatment of conditions related to NAFLD.

公开(公告)号：US20140162976A1

公开(公告)日：2014-06-12

申请号：US14182786

申请日：2014-02-18

Applicant: DSM IP ASSETS B.V.

Inventor： Daniel RAEDERSTORFF ,  Nathalie RICHARD ,  Joseph SCHWAGER ,  Karin WERTZ

IPC: A61K31/726 ,  A61K36/63 ,  A61K31/05

CPC classification number: A61K31/726 ,  A61K31/05 ,  A61K31/737 ,  A61K36/63 ,  A61K2300/00

Abstract: The present invention relates to novel compositions comprising hydroxytyrosol and chondroitin as well as to the use of these compositions as a medicament, in particular as a medicament for the treatment, co-treatment or prevention of inflammatory disorders.

Abstract translation: 本发明涉及包含羟基酪醇和软骨素的新型组合物以及这些组合物作为药物，特别是作为治疗，共同治疗或预防炎症性疾病的药物的用途。