公开(公告)号：US20150320783A1

公开(公告)日：2015-11-12

申请号：US14761834

申请日：2014-01-24

Applicant: DSM IP ASSETS B.V.

Inventor： Christopher Michael BUTT ,  Michael WEISER

IPC: A61K31/7056 ,  A23L1/30 ,  A61K36/758

CPC classification number: A61K31/7056 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/4045 ,  A61K36/758

Abstract: Zanthoxylum piperitum (commonly known as Japanese pepper) seeds, including its mature seeds, contain the NMS precursor/V-methylserotonin 5-O-B-glucoside (“NMS-glucoside”) present in sufficient concentration and are metabolized with sufficient efficiency so as to provide an effective amount of NMS for use in amelioration of menopausal symptoms, including hot flashes/flushes. The Japanese pepper seeds or Japanese pepper seed extracts can also be used to enrich other sources of NMS or NMS precursors in order to provide a nutraceutical or food supplement for controlling hot flashes.

Abstract translation: 花椒椒（俗称日本辣椒）种子，包括其成熟种子，含有足够浓度存在的NMS前体/ V-甲基丝氨酸5-OB-葡萄糖苷（“NMS-葡萄糖苷”），并以足够的效率代谢，以提供 有效量的NMS用于改善绝经期症状，包括潮热/冲洗。 日本胡椒种子或日本胡椒种子提取物也可用于丰富NMS或NMS前体的其他来源，以提供用于控制潮热的营养食品或食品补充剂。

公开(公告)号：US20170181995A1

公开(公告)日：2017-06-29

申请号：US15309470

申请日：2015-05-07

Applicant: DSM IP ASSETS B.V.

Inventor： Michael WEISER ,  Christopher BUTT

IPC: A61K31/201 ,  A61K31/202

CPC classification number: A61K31/201 ,  A61K31/20 ,  A61K31/202 ,  A61K2300/00

Abstract: Disclosed herein are compositions for use in treating anxiety, inflammatory conditions, fertility-related disorders, for increasing cognitive performance and managing weight comprising 10-Hydroxy-2-decenoic acid or a derivative thereof and preferably at least one polyunsaturated fatty acid. The preferred polyunsaturated fatty acid is DHA.

公开(公告)号：US20140213536A1

公开(公告)日：2014-07-31

申请号：US14162875

申请日：2014-01-24

Applicant: DSM IP ASSETS B.V.

Inventor： Christopher Michael BUTT ,  Michael WEISER

IPC: A61K31/7056 ,  A23L1/30 ,  A61K31/4045

CPC classification number: A61K31/7056 ,  A23L33/105 ,  A23V2002/00 ,  A61K31/4045 ,  A61K36/758

Abstract: Zanthoxylum piperitum (commonly known as Japanese pepper) seeds, including its mature seeds, contain the NMS precursor N-methylserotonin S-O-6-glucoside (“NMS-glucoside”) present in sufficient concentration and are metabolized with sufficient efficiency so as to provide an effective amount of NMS for use in amelioration of menopausal symptoms, including hot flashes/flushes. The Japanese pepper seeds or Japanese pepper seed extracts can also be used to enrich other sources of NMS or NMS precursors in order to provide a nutraceutical or food supplement for controlling hot flashes. This invention relates to the marketing of nutraceuticals and food supplements containing these ingredients. Target customers include perimenopausal women, menopausal women and post menopausal women who wish to reduce the risk of experiencing hot flashes.

Abstract translation: 花椒素（俗称日本辣椒）种子，包括其成熟种子，含有足够浓度存在的NMS前体N-甲基丝氨酸SO-6-葡萄糖苷（“NMS-葡萄糖苷”），并以足够的效率代谢，以提供 有效量的NMS用于改善绝经期症状，包括潮热/冲洗。 日本胡椒种子或日本胡椒种子提取物也可用于丰富NMS或NMS前体的其他来源，以提供用于控制潮热的营养食品或食品补充剂。 本发明涉及营养保健品和含有这些成分的食品添加剂的销售。 目标客户包括绝经期妇女，绝经妇女和更年期妇女，希望减少经历潮热的风险。