公开(公告)号：US10280439B2

公开(公告)日：2019-05-07

申请号：US14997530

申请日：2014-07-18

Applicant: DSM IP ASSETS B.V. ,  ROQUETTE FRÈRES SA

Inventor： Mickel Leonardus August Jansen ,  René Verwaal ,  Laurent Segueilha ,  Mélanie Louchart ,  Tania Veiga Dos Inocentes

IPC: C12P7/44 ,  C12P7/46 ,  C12N1/18

Abstract: The present invention relates to a method for a dicarboxylic acid, which method comprises fermenting fungal cells in a vessel comprising a suitable fermentation medium, wherein a least a portion of the fungal cells are reused in the presence of a vitamin and/or a trace element.

公开(公告)号：US09340805B2

公开(公告)日：2016-05-17

申请号：US14662594

申请日：2015-03-19

Applicant: DSM IP ASSETS B.V.

Inventor： Mickel Leonardus August Jansen ,  Rene Verwaal

IPC: C12P7/44 ,  C12P7/46

CPC classification number: C12P7/46 ,  C12P7/44

Abstract: The present invention relates to a process for the production of a dicarboxylic acid. The process comprises fermenting a yeast in the presence of a carbohydrate-containing substrate and low amounts of oxygen at a pH value at which at least 50% of the dicarboxylic acid is in the acid form. The process of the present invention allows for high yields of the dicarboxylic acid product and is more cost-effective than existing processes in which the salt is produced which during recovery has to be converted to the acid. It also leads to a simpler and more convenient downstream processing.