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公开(公告)号：US09689005B2
公开(公告)日：2017-06-27
申请号：US14044722
申请日：2013-10-02
Applicant: DSM IP ASSETS B.V.
Inventor： Rene Verwaal , Liang Wu , Robbertus Antonius Damveld , Cornelis Maria Jacobus Sagt
Abstract: The present invention relates to a recombinant eukaryotic cell selected from a yeast of a filamentous fungus comprising a nucleotide sequence encoding a NAD(H)-dependent fumarate reductase that catalyzes the conversion of fumaric acid to succinic acid. The invention further relates to a process for the production of succinic acid wherein the eukaryotic cell according to the present invention is used.
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公开(公告)号：US09556459B2
公开(公告)日：2017-01-31
申请号：US14070770
申请日：2013-11-04
Applicant: DSM IP ASSETS B.V.
Inventor： Rene Verwaal , Liang Wu , Robbertus Antonius Damveld , Cornelis Maria Jacobus Sagt
Abstract: The present invention relates to a recombinant yeast comprising a nucleotide sequence encoding a heterologous enzyme that catalyses the conversion of malic acid to fumaric acid. The invention further relates to a process for the production of a dicarboxylic acid wherein the yeast according to the present invention is used.
Abstract translation: 本发明涉及包含编码异源酶的核苷酸序列的重组酵母，其催化苹果酸向富马酸的转化。 本发明还涉及一种生产二羧酸的方法，其中使用了本发明的酵母。
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公开(公告)号：US09340805B2
公开(公告)日：2016-05-17
申请号：US14662594
申请日：2015-03-19
Applicant: DSM IP ASSETS B.V.
Inventor： Mickel Leonardus August Jansen , Rene Verwaal
Abstract: The present invention relates to a process for the production of a dicarboxylic acid. The process comprises fermenting a yeast in the presence of a carbohydrate-containing substrate and low amounts of oxygen at a pH value at which at least 50% of the dicarboxylic acid is in the acid form. The process of the present invention allows for high yields of the dicarboxylic acid product and is more cost-effective than existing processes in which the salt is produced which during recovery has to be converted to the acid. It also leads to a simpler and more convenient downstream processing.
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