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公开(公告)号:US20190249201A1
公开(公告)日:2019-08-15
申请号:US16309422
申请日:2017-06-13
Applicant: DSM IP ASSETS B.V.
Inventor: Ioannis PAPAPETRIDIS , Antonius Jeroen Adriaan VAN MARIS , Jacobus Thomas PRONK , Paulus Petrus DE WAAL , Niels LAURET , Maarten Dirk VERHOEVEN , Jozef Petrus Johannes SCHMITZ
CPC classification number: C12P7/06 , C12N1/16 , C12N9/1205 , C12N9/88 , C12N15/81 , C12R1/645 , C12Y207/01019 , C12Y401/01039 , Y02E50/17
Abstract: The present invention describes a recombinant yeast cell functionally expressing one or more heterologous nucleic acid sequences encoding for ribulose-1,5-phosphate carboxylase/oxygenase (EC4.1.1.39; Rubisco), and optionally one or more molecular chaperones for Rubisco, and one or more phosphoribulokinase (EC2.7.1.19; PRK), wherein the phosphoribulokinase is under control of a promoter (the “PRK promoter”) that enables higher expression under anaerobic conditions than under aerobic conditions.
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公开(公告)号:US20200255871A1
公开(公告)日:2020-08-13
申请号:US16858163
申请日:2020-04-24
Applicant: DSM IP ASSETS B.V.
Inventor: Ioannis PAPAPETRIDIS , Antonius Jeroen Adriaan VAN MARIS , Jacobus Thomas PRONK , Paulus Petrus DE WAAL , Niels LAURET , Maarten Dirk VERHOEVEN , Jozef Petrus Johannes SCHMITZ
Abstract: The present invention describes a recombinant yeast cell functionally expressing one or more heterologous nucleic acid sequences encoding for ribulose-1,5-phosphate carboxylase/oxygenase (EC4.1.1.39; Rubisco), and optionally one or more molecular chaperones for Rubisco, and one or more phosphoribulokinase (EC2.7.1.19; PRK), wherein the phosphoribulokinase is under control of a promoter (the “PRK promoter”) that enables higher expression under anaerobic conditions than under aerobic conditions.
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