公开(公告)号：US20190054063A1

公开(公告)日：2019-02-21

申请号：US16166357

申请日：2018-10-22

Applicant: DSM IP ASSETS B.V.

Inventor： Szabolcs PETER ,  Joseph SCHWAGER ,  Weerasinghe M. INDRASENA ,  Jaroslav A. KRALOVEC ,  Bernd MUSSLER

IPC: A61K31/355 ,  A61K31/22 ,  A61P1/16

CPC classification number: A61K31/355 ,  A61K31/22 ,  A61P1/16

Abstract: The present invention relates to the use of mixtures of vitamin E and polyunsaturated fatty acids (PUFAs) as agents for the prevention, control and/or treatment of conditions associated with excessive fat accumulation in the liver which is not caused by alcohol abuse. This includes prevention, control and/or treatment of non-alcoholic steatosis in the liver—known as non-alcoholic fatty liver disease (NAFLD)—and/or non-alcoholic steatohepatitis (NASH) in a subject in need thereof. In particular, the present invention relates to the use of such compounds comprising vitamin E acetate and DHA EE as active ingredients in the manufacture of medicaments for the prevention, control and/or treatment of conditions related to NAFLD.

公开(公告)号：US20210369668A1

公开(公告)日：2021-12-02

申请号：US17286926

申请日：2019-10-18

Applicant: DSM IP ASSETS B.V.

Inventor： Weerasinghe M. INDRASENA ,  Jaroslav A. KRALOVEC ,  Bernd MUSSLER

IPC: A61K31/355 ,  A61K31/202 ,  A61K31/375 ,  A61K9/48

Abstract: A composition comprising α-tocopherol acetate (also referred to as Vitamin E acetate “Vit E Acetate”) and docosahexaenoic acid ethyl ester (“DHA EE”), exhibits surprising oxidative stability.

公开(公告)号：US20210238499A1

公开(公告)日：2021-08-05

申请号：US16972153

申请日：2019-06-04

Applicant: DSM IP Assets B.V.

Inventor： Jaroslav A. KRALOVEC ,  Paul Frederick MUGFORD ,  Alfred ROLLE

IPC: C11C3/02

Abstract: A method for producing diglycerides is provided. The method includes combining (i) an oil comprising at least one polyunsaturated fatty acid in the form of ethyl esters, free fatty acids, and/or combinations thereof, (ii) lipase, and (iii) glycerol in water to produce diglycerides with a high level of purity. Highly pure diglycerides obtained according to the method are also provided.