公开(公告)号：US10385308B2

公开(公告)日：2019-08-20

申请号：US14772137

申请日：2014-03-13

Applicant: DSM IP Assets B.V.

Inventor： Joshua Trueheart ,  Jessica McGrath

IPC: C12P7/22 ,  C12N9/22 ,  C12Q1/68 ,  C12N1/08 ,  C12P23/00

Abstract: The present invention relates to the use of a thermophilic nuclease for degrading nucleic acids in vivo and/or in situ, wherein the thermophilic nuclease is heterologous to the host cell and is produced by the host rather than being added exogenously. The present invention further relates to a genetically modified cell which was produced according to the above method. The present invention is particularly beneficial in inactivating the biological activity of recombinant DNA in biomass or biomass-derived products.