公开(公告)号：US20150038415A1

公开(公告)日：2015-02-05

申请号：US14365139

申请日：2012-12-14

Applicant: DSM IP Assets B.V.

Inventor： John Andrew Zupancich

IPC: B29C41/00 ,  A61K9/70 ,  A61K47/34 ,  A61K38/38 ,  A61K47/48 ,  B29C41/12 ,  A61K38/27

CPC classification number: B29C41/003 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/7007 ,  A61K38/27 ,  A61K38/385 ,  A61K47/34 ,  A61K47/545 ,  B29C41/12 ,  B29K2077/00 ,  B29K2105/0035 ,  B29K2105/007 ,  B29K2105/0085 ,  B29K2883/00 ,  B29L2007/008 ,  B29L2031/753

Abstract: Process for the manufacturing of a drug delivery system based on a polymer comprising dispersed bioactive agent via the following process steps: (a) dissolving a polymer in an organic solvent (b) mixing the dissolved polymer with the bioactive agent (c) laminating the mixture between two polymer sheets, whereby at least one of the sheets is permeable to the organic solvent, to provide a film whereby the film can be further processed into the drug delivery system. The drug delivery system is suitable for implantation or injection and comprises fibres, rods, discs, coatings, tubes, films or rolled films. The polymer comprising the dispersed bioactive agent is a biostable, bioerodable or biodegradable polymer selected from the group consisting of polyesteramides, polythioesters, polyesterurethanes, polyesterurea's, PLLA, PLGA, polyesters, polyanhydrides, polycarbonates, polyurethanes, poly (amino acids), polypeptides, polyamides, polysaccharides, polyethers, polysulfones, poly(meth)acrylates, polysiloxanes, polyolefins.

Abstract translation: 用于通过以下工艺步骤制备基于包含分散的生物活性剂的聚合物的药物递送系统的方法：（a）将聚合物溶解在有机溶剂中（b）将溶解的聚合物与生物活性剂混合（c） 在两个聚合物片材之间，由此至少一个片材可渗透有机溶剂，以提供膜，从而可以将膜进一步加工成药物递送系统。 药物输送系统适用于植入或注射，包括纤维，棒，盘，涂层，管，膜或卷膜。 包含分散的生物活性剂的聚合物是选自聚酯酰胺，聚硫酯酯，聚酯氨酯，聚酯脲，PLLA，PLGA，聚酯，聚酐，聚碳酸酯，聚氨酯，聚（氨基酸），多肽，聚酰胺的生物稳定，生物可蚀塑或可生物降解的聚合物 ，多糖，聚醚，聚砜，聚（甲基）丙烯酸酯，聚硅氧烷，聚烯烃。

公开(公告)号：US12214041B2

公开(公告)日：2025-02-04

申请号：US17275729

申请日：2019-09-16

Applicant: DSM IP Assets B.V.

Inventor： Jennifer Al-Rashid ,  Jacob Riffey ,  John Andrew Zupancich

IPC: A61K47/34 ,  A61K9/00 ,  A61K47/32 ,  C08G18/08 ,  C08G18/12 ,  C08G18/32 ,  C08G18/40 ,  C08G18/44 ,  C08G18/48 ,  C08G18/73 ,  C08G18/75

Abstract: In an embodiment, a polyurethane comprises the residues of i. an aliphatic diisocyanate, ii. an aliphatic diol comprising a poly(ethylene oxide) moiety, iii. an aliphatic diol comprising a polycarbonate moiety, and iv. a chain extender, wherein the polyurethane has a melting temperature of 140° C. or less and has a weight average molecular weight of from 100,000 to 500,000 g/mol. In an embodiment, the polyurethane is substantially devoid of catalyst. In an embodiment, the polyurethane is formed by reactive extrusion. In an embodiment, a medical device comprises the polyurethane and a bioactive agent. The medical devices, methods, and polyurethanes may exhibit benefits in end-product biostability, drug release profile, health and safety, and processing speed or reproducibility.

公开(公告)号：US20150246001A1

公开(公告)日：2015-09-03

申请号：US14432899

申请日：2013-10-23

Applicant: DSM IP ASSETS B.V.

Inventor： John Andrew Zupancich ,  Julien François Berard

IPC: A61K9/70 ,  B32B38/10 ,  B32B38/00 ,  A61K38/22 ,  B32B37/24

CPC classification number: A61K9/7007 ,  A61K9/0024 ,  A61K9/0051 ,  A61K9/1647 ,  A61K9/7069 ,  A61K38/22 ,  B32B37/24 ,  B32B38/0012 ,  B32B38/10 ,  B32B2037/243 ,  B32B2367/00 ,  B32B2377/00 ,  B32B2535/00 ,  Y10T156/1051

Abstract: The present invention relates to a process for the manufacturing of a multilayer construct comprising layering at least one drug loaded film from which each film comprises a polymer and at least a drug manufactured by the steps of dissolving the polymer in an organic solvent, mixing the dissolved polymer with the drug, laminating the mixture between at least two polymeric sheets, whereby at least one sheet is permeable to the organic solvent, removing the sheets to provide the drug loaded film, layering the drug loaded film and fusing the drug loaded films into a multilayer construct. The present invention also relates to the multilayer construct obtainable by the process according to the present invention and to the use of the multilayer construct in ophthalmology, cardiovascular, pain management, musculoskeletal, cancer treatment or in vaccine delivery.

Abstract translation: 本发明涉及一种制备多层构造体的方法，包括分层至少一个药物负载膜，每个膜包含聚合物和至少一种通过以下步骤制造的药物：将聚合物溶解在有机溶剂中，将溶解的 与所述药物聚合，将所述混合物层压在至少两个聚合物片材之间，由此至少一个片材对所述有机溶剂是可渗透的，去除所述片材以提供负载药物的膜，分层所述负载药物的膜并将所述载药膜融合到 多层结构。 本发明还涉及通过本发明的方法获得的多层构造物以及该多层构造物在眼科，心血管，疼痛管理，肌肉骨骼，癌症治疗或疫苗递送中的用途。