公开(公告)号：US11643551B2

公开(公告)日：2023-05-09

申请号：US16642053

申请日：2018-08-28

Applicant: DSM IP Assets B.V.

Inventor： Jennifer Al-Rashid ,  Jacob Riffey ,  Chad Sugiyama ,  John Zupancich

IPC: C08L75/08 ,  A61B5/145 ,  A61B5/1473 ,  B01D67/00 ,  B01D69/02 ,  B01D71/54 ,  B01D71/58 ,  C08G18/24 ,  C08G18/28 ,  C08G18/48 ,  C08G18/66 ,  C08G18/73 ,  C08G18/75 ,  C08J5/18 ,  C12Q1/00

CPC classification number: C08L75/08 ,  A61B5/14532 ,  A61B5/14735 ,  B01D67/0011 ,  B01D67/0095 ,  B01D69/02 ,  B01D71/54 ,  B01D71/58 ,  C08G18/244 ,  C08G18/283 ,  C08G18/2825 ,  C08G18/4808 ,  C08G18/4833 ,  C08G18/4854 ,  C08G18/6674 ,  C08G18/73 ,  C08G18/755 ,  C08G18/758 ,  C08J5/18 ,  C12Q1/00 ,  A61B5/14546 ,  B01D2323/12 ,  B01D2325/34 ,  B01D2325/36 ,  C08J2375/08 ,  C08J2475/04 ,  C08L2203/16 ,  C08L2205/025

Abstract: Disclosed are compositions that may be useful for forming synthetic membranes, methods of forming membranes therefrom, and membranes. In an embodiment, a membrane comprises a free hydrophilic polymer comprising a polyoxazoline, and a polyurethane, the polyurethane comprising a backbone comprising the reaction product of a diisocyanate, a polymeric aliphatic 5 diol, and optionally a chain extender.

公开(公告)号：US12252614B2

公开(公告)日：2025-03-18

申请号：US18127892

申请日：2023-03-29

Applicant: DSM IP Assets B.V.

Inventor： Jennifer Al-Rashid ,  Jacob Riffey ,  Chad Sugiyama ,  John Zupancich

IPC: C08L75/08 ,  A61B5/145 ,  A61B5/1473 ,  B01D67/00 ,  B01D69/02 ,  B01D71/54 ,  B01D71/58 ,  C08G18/24 ,  C08G18/28 ,  C08G18/48 ,  C08G18/66 ,  C08G18/73 ,  C08G18/75 ,  C08J5/18 ,  C12Q1/00

Abstract: Disclosed are compositions that may be useful for forming synthetic membranes, methods of forming membranes therefrom, and membranes. In an embodiment, a membrane comprises a free hydrophilic polymer comprising a polyoxazoline, and a polyurethane, the polyurethane comprising a backbone comprising the reaction product of a diisocyanate, a polymeric aliphatic 5 diol, and optionally a chain extender.

公开(公告)号：US12214041B2

公开(公告)日：2025-02-04

申请号：US17275729

申请日：2019-09-16

Applicant: DSM IP Assets B.V.

Inventor： Jennifer Al-Rashid ,  Jacob Riffey ,  John Andrew Zupancich

IPC: A61K47/34 ,  A61K9/00 ,  A61K47/32 ,  C08G18/08 ,  C08G18/12 ,  C08G18/32 ,  C08G18/40 ,  C08G18/44 ,  C08G18/48 ,  C08G18/73 ,  C08G18/75

Abstract: In an embodiment, a polyurethane comprises the residues of i. an aliphatic diisocyanate, ii. an aliphatic diol comprising a poly(ethylene oxide) moiety, iii. an aliphatic diol comprising a polycarbonate moiety, and iv. a chain extender, wherein the polyurethane has a melting temperature of 140° C. or less and has a weight average molecular weight of from 100,000 to 500,000 g/mol. In an embodiment, the polyurethane is substantially devoid of catalyst. In an embodiment, the polyurethane is formed by reactive extrusion. In an embodiment, a medical device comprises the polyurethane and a bioactive agent. The medical devices, methods, and polyurethanes may exhibit benefits in end-product biostability, drug release profile, health and safety, and processing speed or reproducibility.