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1.发明授权公开(公告)号：US08497099B2
公开(公告)日：2013-07-30
申请号：US13762324
申请日：2013-02-07
Applicant: DSM IP Assets B.V.
Inventor： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
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2.发明申请Production of High Levels of DHA in Microalgae Using Modified Amounts of Chloride and Potassium 有权使用改性量的氯化物和钾生产微藻中高含量的DHA公开(公告)号：US20130150604A1
公开(公告)日：2013-06-13
申请号：US13762324
申请日：2013-02-07
Applicant: DSM IP Assets B.V.
Inventor： Paul W. BEHRENS , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
IPC: C12P7/64
CPC classification number: C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
Abstract translation: 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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公开(公告)号：US09834799B2
公开(公告)日：2017-12-05
申请号：US14975670
申请日：2015-12-18
Applicant: DSM IP Assets B.V.
Inventor： Paul W Behrens , John M Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
CPC classification number: C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
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Patent Agency Ranking
4.发明授权Production of high levels of DHA in microalgae using modified amounts of chloride and potassium 有权使用改良量的氯化物和钾在微藻中生产高水平的DHA公开(公告)号：US09249434B2
公开(公告)日：2016-02-02
申请号：US14165459
申请日：2014-01-27
Applicant: DSM IP Assets B.V.
Inventor： Paul W Behrens , John M Thompson , Kirk Apt , Joseph W Pfeifer , James P Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
CPC classification number: C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
Abstract translation: 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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5.发明授权公开(公告)号：US08497100B2
公开(公告)日：2013-07-30
申请号：US13762327
申请日：2013-02-07
Applicant: DSM IP Assets B.V.
Inventor： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
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6.发明申请公开(公告)号：US20130158280A1
公开(公告)日：2013-06-20
申请号：US13762327
申请日：2013-02-07
Applicant: DSM IP Assets B.V.
Inventor： Paul W. BEHRENS , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
IPC: C12P7/64
CPC classification number: C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
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7.发明授权Production of high levels of DHA in microalgae using modified amounts of chloride and potassium 有权使用改良量的氯化物和钾在微藻中生产高水平的DHA公开(公告)号：US08669090B2
公开(公告)日：2014-03-11
申请号：US13762324
申请日：2013-02-07
Applicant: DSM IP Assets B.V.
Inventor： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
CPC classification number: C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
Abstract translation: 公开了使用低水平氯离子的海洋微生物生产高度不饱和脂肪酸的方法，包括异养海洋鞭毛藻Crypthecodinium。 具体地说，通过操纵钠离子和钾离子水平，在低氯化物培养基中生长时，通过海洋微生物增加高度不饱和脂肪酸的生产的方法。 本发明还涉及在低pH水平下由海洋生物生产高度不饱和脂肪酸的方法，并且包括产生低pH耐受菌株的方法。
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8.发明授权公开(公告)号：US08663953B2
公开(公告)日：2014-03-04
申请号：US13762327
申请日：2013-02-07
Applicant: DSM IP Assets B.V.
Inventor： Paul W. Behrens , John M. Thompson , Kirk Apt , Joseph W. Pfeifer, III , James P. Wynn , James Casey Lippmeier , Jaouad Fichtali , Jon Hansen
CPC classification number: C12P7/6427 , A61K36/02 , C11B1/10 , C12P7/6409 , C12P7/6472
Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
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