公开(公告)号：US20240207052A1

公开(公告)日：2024-06-27

申请号：US17927906

申请日：2021-05-28

申请人： DSM IP Assets B.V. ,  MAASTRICHT UNIVERSITAIR MEDISCH CENTRUM+ ,  TECHNISCHE UNIVERSITEIT EINDHOVEN ,  UNIVERSITY MAASTRICHT

发明人： Hendrik OEVERING ,  Franciscus Wilhelmus Maria GELISSEN ,  Jens Christoph THIES ,  Pieter EMANS ,  Alex Kristian ROTH ,  Corrinus Cornelis VAN DONKELAAR ,  Emin Erkan ASIK

IPC分类号： A61F2/30

CPC分类号： A61F2/30756 ,  A61F2002/30016 ,  A61F2002/30028 ,  A61F2002/30056 ,  A61F2002/30065 ,  A61F2002/3008 ,  A61F2002/3009 ,  A61F2002/30299 ,  A61F2002/30321 ,  A61F2002/30494 ,  A61F2002/30757 ,  A61F2002/30761 ,  A61F2310/00215 ,  A61F2310/00239 ,  A61F2310/00329 ,  A61F2310/00592

摘要： Present invention relates to an orthopedic implant having a bone anchoring part comprising a polymer composition comprising a biostable thermoplastic polyurethane (TPU) and 15-70 mass % of inorganic particles comprising zirconia. It was found that this relatively rigid anchoring part allows inserting an implant into a pre-drilled bone hole to form a firm and durable connection to bone, which may be visualized with for example X-ray or MRI methods. The thermoplastic polyurethane composition shows favorable properties, and offers freedom in design and dimensioning of the implant, and in making the implant with common techniques like injection molding. Especially if the implant comprises a cartilage replacing part made from a resilient thermoplastic material compatible with the polyurethane-zirconia composition, like a more flexible TPU composition, the implant may be made with a 2-component injection molding technique. In other aspects, the invention relates to a method of making said orthopedic implant comprising a bone anchoring part with a multi-component injection molding process. The invention further relates to a surgical kit of parts comprising orthopedic implants of the invention, and to the use of an implant or a surgical kit of the invention in orthopedic surgery.

公开(公告)号：US20200283684A1

公开(公告)日：2020-09-10

申请号：US16648079

申请日：2018-09-18

申请人： TECHNISCHE UNIVERSITEIT EINDHOVEN

发明人： Panagiotis KOURIS ,  Michael Dirk BOOT ,  Emiel Jan Maria HENSEN ,  Hendrik OEVERING

IPC分类号： C10G1/04 ,  C10G1/08 ,  C07G1/00

摘要： A process the production of a crude liquid lignin oil (CLO), the process includes the steps of providing a lignin-rich solid feedstock and subjecting the lignin-rich solid feedstock to a treatment in a polar organic solvent in the absence of an effective amount of added reaction promoter, such as a heterogeneous and/or homogeneous catalyst and/or hydrogen, and providing a lignin composition, the treatment includes a step of contacting the lignin-rich solid feedstock with a polar organic solvent under operating conditions of an operating temperature up to 210° C., an operating pressure lower than 50 bar and a residence time up to 240 minutes, wherein the ratio (w/v) of lignin (in lignin-rich feedstock) to polar organic solvent ranges between 1:1.5 and 1:15, or between 1:2 and 1:10 or between 1:2 and 1:5.