Patent search ap:("DYNAMIT NOBEL AG") AND inv:"JANSSEN P" Page 1

1.

发明授权
Optical antipodes d-and l-n-benzoyl-3,4-dihydroxyphenylalanine and a process for their preparation 失效
Title translation: 光学抗体D-和L-N-苯甲酰基-3,4-二羟基苯甲酰胺及其制备方法

公开(公告)号：US3794655A

公开(公告)日：1974-02-26

申请号：US3794655D

申请日：1970-12-18

Applicant: DYNAMIT NOBEL AG

Inventor： SCHUBEL H , JANSSEN P , RATZ H

IPC: C07C103/30 , C07C101/30 , C07D43/24

CPC classification number: C07D453/04

Abstract: OPTICAL ANTIPODES D- AND L-N-BENZOYL-3,4-DIHYDROXYPHENYLALANINE OF THE FORMULA:

1-(PHENYL-CO-NH-CH(-COOH)-CH2-),3,4-DI(HO-)BENZENE

AND THE CINCHONNE SALTS THEREOF. THESE COMPOUNDS ARE MADE BY REACTING CHINCHONINE WITH D- AND OR L-N-BENZOYL-3,4-DIHYDROXYPHENYLALANINE AND THEN CRYSTALLIZING THE SALT FROM MIXTURES OF WATER WITH LOWER KETONES,LOWER ALKANOLS LOWER ETHERS OR MIXTAURES THEREOF IN ORDER TO SEPARATE AND RESOLVE THE OPTICAL ISOMERS. THESE SALTS ARE CLEAVED TO THE OPTICALLY PURE- OR L-N-BENZOYL-3,4-DIHYDROXYPHENYLALANINE WHICH IS ITSELF CLEAVED TO 3,4-DIHYDROXYPHENYLALANIME.

2.

发明授权
Process for the manufacture of pure l-n-benzoyl-3,4-dihydroxyphenylalanine 失效
Title translation: 纯L-N-苯甲酰基-3,4-二羟基苯乙胺的制备方法

公开(公告)号：US3796750A

公开(公告)日：1974-03-12

申请号：US3796750D

申请日：1970-12-18

Applicant: DYNAMIT NOBEL AG

Inventor： SCHUBEL H , JANSSEN P , RATZ H

IPC: C07C231/20 , C07C233/87 , C07C103/30

CPC classification number: C07C51/487

Abstract: PROCESS FOR PRODUCING L-N-BENZOYL-3,4-DHYDROXYPHENYLALANINE BY RESOLVING A MIXED DL-N-BENZOYL-3,4-DIDHYDROXYPHENYL-ALANINE; RECOVERING THE L-ISOMER; REACTING THE D-ISOMER WITH ACETIC ANHYDRIDE; PRECIPITATING THE ACETOXY DERIVATIVE THUS FORMED; HUDROLYZING THE ACRTOXY DERIVATIVE WITH ALKALI METAL TO FORM RACEMIC DL-N-BENZOLY-3,4-DIHYDROXYPHENYLALANINE; RESOLVING THE RACEMATE; RECOVERING THE LISOMER; AND RECYCLING THE D-ISOMER.

3.

发明授权
Method of obtaining the optical antipodes d(-)-and l(+)-alpha-azidophenylacetic acid 失效
Title translation: 获得光学抗体D（ - ） - 和L（+） - 氨基 - 氨基乙酸的方法

公开(公告)号：US3772364A

公开(公告)日：1973-11-13

申请号：US3772364D

申请日：1972-05-23

Applicant: DYNAMIT NOBEL AG

Inventor： BISON G , JANSSEN P , SCHUEBEL H

IPC: C07C117/00

Abstract: A METHOD FOR THE PREPARATION OF AN OPTICALLY ACTIVE FORM OF A-AZIDOPHEYLACETIC BY CONTACTING DL-A-AZIDOPHENYLACETIC WITH AN OPTICALLY ACTIVE FORM OF A-PHENYLETHYLAMINE, RECOVERING A DIASTEREOMERIC SALT THEREOF AND CRYSTALLIZING OUT OF SAID SALT AN OPTICALLY ACTIVE FORM OF SAID A-AZIDOPHENYLACETIC ACID; THE DIASTEREOMERIC SALT OF AN OPTICALLY ACTIVE FORM OF A-AZIDOPHENYLACTIC ACID AND AN OPTICALLY ACTIVE FORM OF A-PHENYLETHYLAMINE.

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