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    Tetraline derivatives, their production and pharmaceutical compositions containing them
    3.
    发明授权
    Tetraline derivatives, their production and pharmaceutical compositions containing them 失效
    四氮烯衍生物，它们的生产和包含它们的药物组合物

    公开(公告)号：US4410519A

    公开(公告)日：1983-10-18

    申请号：US243267

    申请日：1981-03-12

    Applicant: Max P. Seiler ,  Andre Stoll

    Inventor： Max P. Seiler ,  Andre Stoll

    IPC: C07C255/24 ,  A61K31/655 ,  A61K31/275 ,  C07C117/00 ,  C07C121/60

    CPC classification number: C07C255/24

    Abstract: An optically active or racemic 2-amino-5-hydroxy-1,2,3,4-tetrahydronaphthalene wherein the nitrogen atom of the amino group carrier two alkyl groups, one of which is unsubstituted and the other is substituted by at least one functional group, or a physiologically hydrolysable ester thereof in free base form or in the form of an acid addition salt thereof is provided which is active against heart circulatory disorders and Morbus Parkinson and inhibits prolactin secretion inhibition.

    Abstract translation: 光学活性或外消旋的2-氨基-5-羟基-1,2,3,4-四氢化萘，其中氨基的氮原子携带两个烷基，其中一个是未取代的，另一个被至少一个官能 提供其对游离碱形式或其酸加成盐形式的生理上可水解的酯，其对心脏循环障碍和莫斯帕金森病具有活性并且抑制催乳素分泌抑制。

    Process for the preparation of azidobenzal compounds
    4.
    发明授权
    Process for the preparation of azidobenzal compounds 失效
    制备叠氮基亚苄基化合物的方法

    公开(公告)号：US4354976A

    公开(公告)日：1982-10-19

    申请号：US218250

    申请日：1980-12-19

    Applicant: Michael Romer

    Inventor： Michael Romer

    IPC: C07C247/16 ,  C07C67/00 ,  C07C241/00 ,  C08K5/22 ,  C09D115/00 ,  C07C117/00

    CPC classification number: C09D115/00 ,  C07C247/00 ,  C08K5/22 ,  C08C19/10 ,  Y02P20/55

    Abstract: A process for preparing a 2,6-bis-[(4-azidophenyl)methylene]-cyclohexanone of the formula ##STR1## wherein R is hydrogen or alkyl of 1-6 C atoms, comprises condensing a cyclohexanone of the formula ##STR2## wherein R is as defined above, with 4-aminobenzaldehyde, the 4-amino group optionally being protected, in the presence of an alkaline condensing agent; removing the protective group when the 4-amino group is protected; diazotizing the resultant 2,6-bis-[(4-aminophenyl)methylene]-cyclohexanone of the formula ##STR3## wherein R is as defined above, and reacting the diazotization product with an alkali metal azide.

    Abstract translation: 制备式“IMAGE”的2,6-二 - [（4-叠氮基苯基）亚甲基] - 环己酮的方法，其中R是氢或1-6C原子的烷基，包括将下式的环己酮： 其中R如上定义，与4-氨基苯甲醛，4-氨基任选被保护，在碱性缩合剂的存在下; 当4-氨基被保护时，去除保护基; 将得到的式（IMAGE）的2,6-二 - [（4-氨基苯基）亚甲基] - 环己酮重氮化，其中R如上定义，并使重氮化产物与碱金属叠氮化物反应。

    Production of carbonyl compounds substituted in .alpha.-position
    5.
    发明授权
    Production of carbonyl compounds substituted in .alpha.-position 失效
    生成在{60-位取代的羰基化合物

    公开(公告)号：US3939184A

    公开(公告)日：1976-02-17

    申请号：US344632

    申请日：1973-03-26

    Applicant: Horst Koenig ,  Horst Metzger ,  Werner Reif

    Inventor： Horst Koenig ,  Horst Metzger ,  Werner Reif

    IPC: C07C323/22 ,  C07C69/66 ,  C07C117/00 ,  C07C121/76 ,  C07C122/00

    CPC classification number: C07C45/518 ,  C07C201/08 ,  C07C231/10 ,  C07C231/12 ,  C07C247/12 ,  C07C253/04 ,  C07C253/30 ,  C07C255/00 ,  C07C315/00 ,  C07C319/14 ,  C07C323/22

    Abstract: Production of carbonyl compounds substituted in the .alpha.-position and having the formula: ##EQU1## wherein R.sup.1 is alkyl, aralkyl, phenyl, toluyl, naphthyl, alkoxy or amino; R.sup.2 is hydrogen ##EQU2## A is hydrogen, alkyl, halo or ##EQU3## R.sup.6 is hydrogen or methyl, and R.sup.11 is alkyl; wherein said compounds are formed by reacting a sulfur ylide having the formula: ##EQU4## wherein Y is the radical ##EQU5## and R.sup.9 and R.sup.10 are alkyl or phenyl, with a solution containing both an electrophilic agent A' that is converted into the radical A and a nucleophilic agent B' that is converted into the radical B. The resulting carbonyl compounds are useful as starting materials for the production of paper, textile, and leather auxiliaries, plant protection agents, alkyd resins, polyesters and polyamides.

    Abstract translation: 制备在α-位取代的具有下式的羰基化合物：其中R1是烷基，芳烷基，苯基，甲苯基，萘基，烷氧基或氨基; R2是氢R6R6O R6R6O || PARALLEL || PARALLEL -CH-CH-CN，-C-R1或-CH-CH-C-OR11; A是氢，烷基，卤素或R6R6 | -CH-CH-CN R6是氢或甲基，R11是烷基; 其中所述化合物通过使具有下列结构式的硫叶立德反应形成：其中Y是基团CH 3 R 9 = S ANGLE或= S ANGLE PARALLEL OCH 3 R 10，R 9和R 10是烷基或苯基，与 含有转化为自由基A的亲电子试剂A'和转化为自由基B的亲核试剂B'的溶液。得到的羰基化合物可用作生产纸，纺织品和皮革助剂的原料 植物保护剂，醇酸树脂，聚酯和聚酰胺。

    Silyl-azidoformates
    7.
    发明授权
    Silyl-azidoformates 失效
    SILYL-AZIDOFORMATES

    公开(公告)号：US3705911A

    公开(公告)日：1972-12-12

    申请号：US3705911D

    申请日：1971-11-16

    Applicant: HERCULES INC

    Inventor： THOMSON J BRENT

    IPC: C07F7/10 ,  C07F7/18 ,  C08J5/06 ,  C08J5/08 ,  C08K9/06 ,  C09D4/00 ,  C07C117/00 ,  C07D109/00

    CPC classification number: C08J5/06 ,  C07F7/10 ,  C07F7/1836 ,  C08J5/08 ,  C08J2383/04 ,  C08K9/06 ,  C09D4/00 ,  C08G77/22

    Abstract: DISCLOSED ARE NITROGEN CONTAINING SILANE COMPOUNDS OF THE FORMULA

    (X)A-SI(-(T)B)-(R-(O-C(=O)-N3)C)D

    WHERE R IS AN ORGANIC RADICAL, X IS SELECTED FROM HALO, HYDROXY, ALKOXY, ARYLOXY, ORGANO OXYCARBONYL, AZIDO, AMINE, AND AMIDE RADICALS; T IS SELECTED FROM ALKYL, CYCLOALKYL, ARYL, ALKARYL, AND ARALKYL RADICALS; A IS AN INTEGER FROM 1 TO 3; B IS AN INTEGER FROM 0 TO 2; C IS AN INTEGER FROM 1 TO 10; D IS AN INTEGER FROM 1 TO 3; AND A+B+D EQUALS 4;

    -OOC-C(-R'')-N2, -OOC-N3, AND -SO2-N3

    WHERE R'' IS SELECTED FROM HYDROGEN, ALKYL, CYCLOALKYL, ARYL AND -COOR" RADICALS; WHERE R" IS SELECTED FROM ALKYL, CYCLOALKYL, AND ARYL RADICALS.

    Dimeric azidophospha (iii)-carboranes
    8.
    发明授权
    Dimeric azidophospha (iii)-carboranes 失效
    二甲基氨基甲酸（III）-CARBORANES

    公开(公告)号：US3562298A

    公开(公告)日：1971-02-09

    申请号：US3562298D

    申请日：1967-10-09

    Applicant: OLIN CORP

    Inventor： ALEXANDER ROY P ,  SCHROEDER HANSJUERGEN A

    IPC: C07F5/02 ,  C07F9/6596 ,  C08G79/14 ,  C07C117/00 ,  C07D107/02

    CPC classification number: C07F9/6596 ,  C07F5/027 ,  C08G79/14 ,  Y10S149/121

    Abstract: DIMERIC AZIDOPHOSPHA (III)-CARBORANES ARE PREPARED BY REACTING A DIMERIC HALOPHOSPHA (III)-CARBORANE, SUCH AS:

    CL-P
    WITH AN ALKALI METAL AZIDE SUCH AS SODIUM AZIDE IN THE PRESENCE OF AN INORGANIC LIQUID AND A TEMPERATURE RANGING FROM ABOUT -20*C. TO ABOUT +80*C. THE DIMERIC AZIDOPHOSPHA (III)-CARBORANES CAN BE CONDENSED WITH A DIPHOSPHINE TO YIELD VALUABLE POLYMERIC MATERIALS WHICH, WHEN COMPOUNDED WITH INERT MINERAL FILLERS AND PRESSURE MOLDED, ARE SUITABLE FOR USE IN HIGH PRESSURE AND HIGH TEMPERATURE APPLICATIONS.

    4-azido-4,4-dinitro-1-butanol and derivatives thereof
    10.
    发明授权
    4-azido-4,4-dinitro-1-butanol and derivatives thereof 失效
    4-叠氮基-4,4-二硝基-1-丁醇及其衍生物

    公开(公告)号：US4795593A

    公开(公告)日：1989-01-03

    申请号：US82775

    申请日：1987-08-05

    Applicant: Milton B. Frankel ,  James F. Weber

    Inventor： Milton B. Frankel ,  James F. Weber

    IPC: C06B25/00 ,  C07C205/15 ,  C07C117/00

    CPC classification number: C07C205/15 ,  C06B25/00 ,  C07C205/44 ,  C07C247/00

    Abstract: There is provided the compound 4-azido-4,4-dinitro-1-butanol (ADNBOH) and a method for making same which comprises reacting trinitromethane and acrolein at a reduced temperature to provide 4,4,4-trinitro-butyraldehyde (TNBAl), reducing the TNBSl to provide 4,4-trinitro-1-butanol (TNBOH) which is further reduced to provide 4,4-dinitro-1-butanol (DNBOH), reacting the DNBOH with acetyl chloride to provide 4,4-dinitro-1-butyl acetate (DNBAc), reacting the DNBAc with an alkali metal azide in an electrolysis cell to provide 4-azido-4,4-dinitro-1-butyl acetate (ADNBAc) and reacting the ADNBAc with a lower alcohol and recovering the 4-azido-4,4-dinitro-1-butanol (ADNBOH).Also provided are several azidodinitro derivatives of 4-azido-4,4-dinitro-1-butanol and methods for making same.

    Abstract translation: 提供化合物4-叠氮基-4,4-二硝基-1-丁醇（ADNBOH）及其制备方法，其包括在降低的温度下使三硝基甲烷和丙烯醛反应，得到4,4,4-三硝基丁醛（TNBAl ），还原TNBS1以提供4 - 三硝基-1-丁醇（TNBOH），进一步还原以提供4,4-二硝基-1-丁醇（DNBOH），使DNBOH与乙酰氯反应，得到4,4-二硝基-1-丁醇 二丁基-1-丁基乙酸酯（DNBAc），使DNBAc与电解槽中的碱金属叠氮化物反应，得到4-叠氮基-4,4-二硝基-1-丁酸乙酯（ADNBAc），并使ADNBAc与低级醇和 回收4-叠氮基-4,4-二硝基-1-丁醇（ADNBOH）。 还提供了4-叠氮基-4,4-二硝基-1-丁醇的几种叠氮基硝基衍生物及其制备方法。

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